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Volumn 336, Issue 3, 2001, Pages 161-180
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Synthesis and anti-HIV activity of glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir
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Author keywords
D Glucose prodrugs; HIV; Indinavir; Nelfinavir; Protease inhibitors; Saquinavir
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Indexed keywords
CONCENTRATION (PROCESS);
DRUG DOSAGE;
ESTERS;
HYDROLYSIS;
STABILITY;
BLOOD BRAIN BARIERS;
CARBOHYDRATES;
5 [3 O (DEXTRO GLUCOSE)]PENTANOIC ACID 1 (3 TERT BUTYLCARBAMOYLOCTAHYDRO 4A,8A ISOQUINOLIN 2 YLMETHYL) 2 [3 CARBAMOYL 2 [(QUINOLINE 2 CARBONYL)AMINO]PROPIONYLAMINO] 3 PHENYLPROPYL ESTER BISTRIFLUOROACETATE;
5 [3 O (DEXTRO GLUCOSE)]PENTANOIC ACID 1 [2 BENZYL 5 (2 TERT BUTYLCARBAMOYL 4 PYRIDIN 3 YLMETHYLPIPERAZIN 1 YL) 4 HYDROXYPENTANOYLAMINO]INDAN 2 YL ESTER TRIFLUOROACETATE;
[3 O (1,2;5,6 DI O ISOPROPYLIDENE ALPHA DEXTRO GLUCOFURANOSE)]ACETIC ACID 1 (3 TERT BUTYLCARBAMOYLOCTAHYDRO 4A,8A ISOQUINOLIN 2 YLMETHYL) 2 [3 CARBAMOYL 2 [(QUINOLINE 2 CARBONYL)AMINO]PROPIONYLAMINO] 3 PHENYLPROPYL ESTER;
[3 O (DEXTRO GLUCOSE)]CARBAMIC ACID 1 (2 TERT BUTYLCARBAMOYL 4 PYRIDIN 3 YLMETHYLPIPERAZIN 1 YLMETHYL) 3 (2 HYDROXYINDAN 1 YLCARBAMOYL) 4 PHENYLBUTYL ESTER BISTRIFLUOROACETATE;
[4 (3 O DEXTRO GLUCOSE)BUTYL]CARBAMIC ACID 1 (3 TERT BUTYLCARBAMOYLOCTAHYDRO 4A,8A ISOQUINOLIN 2 YLMETHYL) 2 (3 HYDROXY 2 METHYLBENZOYLAMINO) 3 PHENYLSULFANYLPROPYL ESTER BISTRIFLUOROACETATE;
[4 (3 O DEXTRO GLUCOSE)BUTYL]CARBAMIC ACID 1 (3 TERT BUTYLCARBAMOYLOCTAHYDRO 4A,8A ISOQUINOLIN 2 YLMETHYL) 2 [3 CARBAMOYL 2 [(QUINOLINE 2 CARBONYL)AMINO]PROPIONYLAMINO] 3 PHENYLPROPYL ESTER TETRAKISTRIFLUOROACETATE;
CARBAMIC ACID;
ESTER;
GLUCOSE;
HYDROXYL GROUP;
INDINAVIR;
NELFINAVIR;
PRODRUG;
PROTEINASE INHIBITOR;
SAQUINAVIR;
SUCCINIC ACID 1 (3 TERT BUTYLCARBAMOYLOCTAHYDRO 4A,8A ISOQUINOLIN 2 YLMETHYL) 2 [3 CARBAMOYL 2 [(QUINOLINE 2 CARBONYL)AMINO]PROPIONYLAMINO] 3 PHENYLPROPYL ESTER 4 (3 O DEXTRO GLUCOSE) BUTYL ESTER BISTRIFLUOROACETATE;
SUCCINIC ACID 1 (3 TERT BUTYLCARBAMOYLOCTAHYDRO 4A,8A ISOQUINOLIN 2 YLMETHYL) 2 [3 CARBAMOYL 2 [(QUINOLINE 2 CARBONYL)AMINO]PROPIONYLAMINO] 3 PHENYLPROPYL ESTER 4 [3 O (1,2;5,6 DI O ISOPROPYLIDENE ALPHA DEXTRO GLUCOFURANOSE)] BUTYL ESTER;
SUCCINIC ACID 1 [2 BENZYL 5 (2 TERT BUTYLCARBAMOYL 4 PYRIDIN 3 YLMETHYLPIPERAZIN 1 YL) 4 HYDROXYPENTANOYLAMINO]INDAN 2 YL ESTER 4 [3 O (1,2;5,6 DI O ISOPROPYLIDENE ALPHA DEXTRO GLUCOFURANOSE)] BUTYL ESTER;
UNCLASSIFIED DRUG;
ANTIVIRAL ACTIVITY;
ARTICLE;
CHEMICAL REACTION;
CONCENTRATION RESPONSE;
CONTROLLED STUDY;
CYTOTOXICITY;
DRUG BIOAVAILABILITY;
DRUG HYDROLYSIS;
DRUG PENETRATION;
DRUG POTENCY;
DRUG STABILITY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
GLUCOSE TRANSPORT;
HUMAN;
HUMAN CELL;
HUMAN IMMUNODEFICIENCY VIRUS;
INCUBATION TIME;
PRIORITY JOURNAL;
VIRUS INHIBITION;
CARBAMATES;
CELL SURVIVAL;
CROSS-LINKING REAGENTS;
ESTERS;
GLUCOSE;
HALF-LIFE;
HIV PROTEASE INHIBITORS;
HIV-1;
HUMANS;
HYDROLYSIS;
INDINAVIR;
NELFINAVIR;
PRODRUGS;
SAQUINAVIR;
TUMOR CELLS, CULTURED;
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EID: 0035160001
PISSN: 00086215
EISSN: None
Source Type: Journal
DOI: 10.1016/S0008-6215(01)00260-9 Document Type: Article |
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Times cited : (29)
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References (34)
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