Inhibition of CHK1 kinase by Gö6976 converts 8-chloro-adenosine-induced G2/M arrest into S arrest in human myelocytic leukemia K562 cells

Biochemical Pharmacology

Volumn 77, Issue 5, 2009, Pages 770-780

  Jia, Xiu Zhen ^a   Yang, Sheng Yong ^a,b   Zhou, Jing ^c   Li, Shu Yan ^a   Ni, Ju Hua ^a   An, Guo Shun ^a   Jia, Hong Ti ^a,c  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

8 Chloro adenosine; CHK1 inhibitor G 6976; DNA damage; G2 M checkpoint; Human myelocytic leukemia K562 cell; Intra S phase checkpoint

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 8 CHLOROADENOSINE; 8 CHLOROADENOSINE 3',5' PHOSPHATE; ADENOSINE DERIVATIVE; ADENOSINE TRIPHOSPHATE; ATM PROTEIN; BRCA1 PROTEIN; CHECKPOINT KINASE 1; NIBRIN; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL GROWTH; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME INHIBITION; EXPOSURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; MYELOID LEUKEMIA; PRIORITY JOURNAL; RNA METABOLISM; WESTERN BLOTTING;

2-CHLOROADENOSINE; BLOTTING, WESTERN; BRCA1 PROTEIN; CARBAZOLES; CELL CYCLE PROTEINS; CELL DIVISION; DNA-BINDING PROTEINS; FLOW CYTOMETRY; G2 PHASE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; K562 CELLS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; REPLICATION ORIGIN; S PHASE; TUMOR SUPPRESSOR PROTEINS;

EID: 59749098720     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.11.008     Document Type: Article

References (48)

1. Rohlff C., Clair T., and Cho-Chung Y.S. 8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. J Biol Chem 268 (1993) 5774-5782
2. Tortora G., Pepe S., Yokozaki H., Meissner S., and Cho-Chung Y.S. Cooperative effect of 8-Cl-cAMP and rhGM-CSF on the differentiation of HL-60 human leukemia cells. Biochem Biophys Res Commun 177 (1991) 1133-1140
3. Grbovic O., Jovic V., Ruzdijic S., Pejanovic V., Rakic L., and Kanazir S. 8-Cl-cAMP affects glioma cell-cycle kinetics and selectively induces apoptosis. Cancer Invest 20 (2000) 972-982
4. Kim S.N., Ahn Y.H., Kim S.G., Park S.D., Cho-Chung Y.S., and Hong S.H. 8-Cl-cAMP induces cell cycle-specific apoptosis in human cancer cells. Int J Cancer 93 (2001) 33-41
5. Fassina G., Aluigi M.G., Gentleman S., Wong P., Cai T., Albini A., et al. The cAMP analog 8-Cl-cAMP inhibits growth and induces differentiation and apoptosis in retinoblastoma cells. Int J Cancer 72 (1997) 1088-1094
6. Halgren R.G., Traynor A.E., Pillay S., Zell J.L., Heller K.F., Krett N.L., et al. 8-Cl-cAMP cytotoxicity in both steroid sensitive and insensitive multiple myeloma cell lines is mediated by 8-Cl-adenosine. Blood 92 (1998) 2893-2898
7. Carlson C.C., Chinery R., Burnham L.L., and Dransfield D.T. 8-Cl-adenosine-induced inhibition of colorectal cancer growth in vitro and in vivo. Neoplasia 2 (2000) 441-448
8. Gandhi V., Ayres M., Halgren R.G., Krett N.L., Newman R.A., and Rosen S.T. 8-chloro-cAMP and 8-chloro-adenosine act by the same mechanism in multiple myeloma cells. Cancer Res 61 (2001) 5474-5479
9. Ahn Y.H., Jung J.M., and Hong S.H. 8-Cl-cAMP and its metabolite, 8-Cl-adenosine induce growth inhibition in mouse fibroblast DT cells through the same pathways; protein kinase C activation and cyclin B downregulation. J Cell Physiol 201 (2004) 277-285
10. Ahn Y.H., Jung J.M., and Hong S.H. 8-Chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells. Cancer Res 65 (2005) 4896-4901
11. Stellrecht C.M., Rodriguez Jr. C.O., Ayres M., and Gandhi V. RNA directed actions of 8-chloro-adenosine in multiple myeloma cells. Cancer Res 63 (2003) 7968-7974
12. Chen L.S., and Sheppard T.L. Chain termination and inhibition of Saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogs. J Biol Chem 279 (2004) 40405-40411
13. Bajic A., Stanimirovic Z., and Stevanovic J. Genotoxicity potential of 8-Cl-cyclic adenosine monophosphate assessed with cytogenetic tests in vivo. Arch Med Res 35 (2004) 209-214
14. Yang S.-Y., Jia X.-Z., Feng L.-Y., Li S.-Y., An G.-S., Ni J.-H., et al. Inhibition of topoisomerase II by 8-chloro-adenosine triphosphate induces DNA double-stranded breaks in 8-chloro-adenosine-exposed human myelocytic leukemia K562 cells. Biochem Pharmacol 77 (2009) 433-443
15. Kastan M.B., and Bartek J. Cell-cycle checkpoints and cancer. Nature 432 (2004) 316-323
16. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3 (2003) 155-168
17. Liu Q.H., Guntuku S., Cui X.S., Matsuoka S., Cortez D., Tamai K., et al. Chk1 is an essential kinase that is regulated by ATR and required for the G2/M DNA damage checkpoint. Genes Dev 14 (2000) 1448-1459
18. Rogakou E.P., Boon C., Redon C., and Bonner W.M. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146 (1999) 905-915
19. Thiriet C., and Hayes J.J. Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair. Mol Cell 18 (2005) 617-622
20. Lim D.S., Kim S.T., Xu B., Maser R.S., Lin J.Y., Petrini J.H.J., et al. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404 (2000) 613-617
21. Kim S.T., Xu B., and Kastan M.B. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev 16 (2002) 560-570
22. Yazdi P.T., Wang Y., Zhao S., Patel N., Lee EY-HP, and Qin J. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev 16 (2002) 571-582
23. 2-phase checkpoints after ionizing irradiation. Mol Cell Biol 21 (2001) 3445-3450
24. Kawabe T. G2 checkpoint abrogation as a cancer specific, cell cycle disruption. Ann Cancer Res Ther 13 (2005) 17-22
25. Kohn E.A., Yoo C.J., and Eastman A. The protein kinase C inhibitor Gö6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints. Cancer Res 63 (2003) 31-35
26. Ishimi Y., Komamura-Kohno Y., Kwon H.J., Yamada K., and Nakanishi M. Identification of MCM4 as a target of the DNA replication block checkpoint system. J Biol Chem 278 (2003) 24644-24650
27. Zhang H.-Y., Gu Y.-Y., Li Z.-G., Jia Y.-H., Yuan L., Li S.-Y., et al. Exposure of human lung cancer cells to 8-chloro-adenosine induces G2/M arrest and mitotic catastrophe. Neoplasia 6 (2004) 802-812
28. Gu Y.-Y., Zhang H.-Y., Zhang H.-J., Li S.-Y., Ni J.-H., and Jia H.-T. 8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells. Biochem Pharmacol 72 (2006) 541-550
29. Huang X., Okafuji M., Traganos F., Luther E., Holden E., and Darzynkiewicz Z. Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin. Cytometry A 58 (2004) 99-110
30. Liu L.F. DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem 58 (1989) 351-375
31. Yarden R.I., Pardo-Reoyo S., Sgagias M., Cowan K.H., and Brody L.C. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet 30 (2002) 285-289
32. Falck J., Petrini J.H.J., Williams B.R., Lukas J., and Bartek J. The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat Genet 30 (2002) 290-294
33. Buscemi G., Savio C., Zannini L., Miccichè F., Masnada D., Nakanishi M., et al. Chk2 activation dependence on Nbs1 after DNA damage. Mol Cell Biol 21 (2001) 5214-5222
34. Bartek J., and Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3 (2003) 421-429
35. Kastan M.B., and Lim D.S. The many substrates and functions of ATM. Mol Cell Biol 1 (2000) 179-186
36. Matsuoka S., Huang M., and Elledge S.J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282 (1998) 1893-1897
37. Chaturvedi P., Eng W.K., Zhu Y., Mattern M.R., Mishra R., Hurle M.R., et al. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene 18 (1999) 4047-4054
38. Kitagawa R., Bakkenist C.J., McKinnon P.J., and Kastan M.B. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev 18 (2004) 1423-1438
39. Wiltshire T., Senft J., Wang Y., Konat G.W., Wenger S.L., Reed E., et al. BRCA1 contributes to cell cycle arrest and chemoresistance in response to the anticancer agent irofulven. Mol Pharmacol 71 (2007) 1051-1060
40. Michel B., Ehrlich S.D., and Uzest M. DNA double-strand breaks caused by replication arrest. Eur Mol Biol Org J 16 (1997) 430-438
41. Cortés-Ledesma F., and Aguilera A. Double-strand breaks arising by replication through a nick are repaired by cohesin-dependent sister-chromatid exchange. Eur Mol Biol Org Rep 7 (2006) 919-926
42. Hirao A., Kong Y.Y., Matsuoka S., Wakeham A., Ruland J., Yoshida H., et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287 (2000) 1824-1827
43. Wang J., Wiltshire T., Wang Y., Mikell C., Burks J., Cunningham C., et al. ATM-dependent CHK2 activation induced by anticancer agent, Irofulven. J Biol Chem 279 (2004) 39584-39592
44. Rotman G., and Shiloh Y. ATM: a mediator of multiple responses to genotoxic stress. Oncogene 18 (1999) 6135-6144
45. Zou L., and Stillman B. Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin dependent kinases and Cdc7p-Dbf4p kinase. Mol Cell Biol 20 (2000) 3086-3096
46. Tanaka Y., Koide S.S., Yoshihara K., and Kamiya T. Poly(ADP-ribose) synthetase is phosphorylated by protein kinase C in vitro. Biochem Biophys Res Commun 148 (1987) 709-717
47. Bentle M.S., Reinicke K.E., Bey E.A., Spitz D.R., and Boothman D.A. Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair. J Biol Chem 281 (2006) 33684-33696
48. Bauer P.I., Farkas G., Buday L., Mikala G., Meszaros G., Kun E., et al. Inhibition of DNA binding by the phosphorylation of poly ADP-ribose polymerase protein catalysed by protein kinase C. Biochem Biophys Res Commun 187 (1992) 730-736