8Cl-cAMP cytotoxicity in both steroid sensitive and insensitive multiple myeloma cell lines is mediated by 8Cl-adenosine

Blood

Volumn 92, Issue 8, 1998, Pages 2893-2898

  Halgren, Robert G ^a   Traynor, Ann E ^b   Pillay, Shafali ^b   Zell, Joann L ^b   Heller, Kimberly F ^b   Krett, Nancy L ^b   Rosen, Steven T ^b  

^a NORTHWESTERN UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

8 CHLOROADENOSINE 3',5' PHOSPHATE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG EFFECT; DRUG SCREENING; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; PRIORITY JOURNAL;

EID: 0032532354     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.8.2893.420k01_2893_2898     Document Type: Article

References (26)

1. Alexanian R, Dimopolous M: The treatment of multiple myeloma. N Engl J Med 330:484, 1994
2. Anderson KC: Multiple myeloma: Advances in disease biology and implications for therapy, in Perry MC (ed): American Society of Clinical Oncology Educational Book, 33rd Annual Meeting. Philadelphia, PA, Saunders, 1997, p 135
3. Goldman-Leikin RE, Salwen HR, Herst CV, Variakojis D, Bian M, Lebeau M, Selvanayagan P, Marder R, Anderson R, Weitzman S, Rosen ST: Characterization of a novel myeloma cell line. J Lab Clin Invest 113:355, 1989
4. Moalli PA, Pillay S, Weiner D, Leikin R, Rosen ST: A mechanism of resistance to glucocorticoids in multiple myeloma: Transient expression of a truncated glucocorticoid receptor mRNA. Blood 79:213, 1992
5. Moalli PA, Pillay S, Krett NL, Rosen ST: Alternately spliced glucocorticoid receptor messenger RNAs in glucocorticoid-resistant human multiple myeloma cells. Cancer Res 53:3877, 1993
6. Dowd DR, Miesfeld RL: Evidence that glucocorticoid- and cyclic AMP-induced apoptotic pathways in lymphocytes share distal events. Mol Cell Biol 12:3600, 1992
7. Krett NL, Zell JL, Halgren RG, Pillay S, Traynor AE, Rosen ST: cAMP mediated cytotoxicity in steroid sensitive and resistant myeloma. Clin Cancer Res 3:1781, 1997
8. Tortora G, Ciardiello F, Pepe S, Tagliaferri P, Ruggiero A, Bianco C, Guarrasi R, Miki K, Bianco AR: Phase I clinical study with 8-chloro-cAMP and evaluation of immunological effects in cancer patients. Clin Cancer Res 1:377, 1995
9. Gong J, Traganos F, Darzynkiewicz Z: A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry, Anal Biochem 218:314, 1994
10. Airas L, Jalkanen S: CD73 mediates adhesion of B cells to follicular dendritic cells. Blood 88:1755, 1996
11. Williams B A, Manzer A, Blay J, Hoskin DW: Adenosine acts through a novel extracellular receptor to inhibit granule exocytosis by natural killer cells. Biochem Biophys Res Commun 231:264, 1997
12. Belloni FL, Elkin PL, Giannotto B: Inhibition by adenosine of histamine and leukotriene release from human basophils. Biochem Pharmacol 38:1717, 1989
13. Hardin J, MacLeod S, Grigorieva I, Chang R, Barlogie B, Xiao H, Epstein J: Interleukin-6 prevents dexamethasone-induced myeloma cell death. Blood 84:3063, 1994
14. Wyllie AH: Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284:555, 1980
15. Collins RJ, Harmon BV, Gobe GC, Kerr JF: Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis. Int J Radiat Biol 61:451, 1992
16. Rohlff C, Clair T, Cho-Chung YS: 8-Cl-cAMP induces truncation and down-regulation of the Riot subunit and up-regulation of the RIIβ subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. J Biol Chem 268:5774, 1993
17. Langeveld CH, Jongenelen CA, Heimans JJ, Stoof JC: 8-chloro-cyclic adenosine monophosphate, a novel cyclic AMP analog that inhibits human glioma cell growth in concentrations that do not induce differentiation. Exp Neurol 117:196, 1992
18. Cho-Chung, YS: Role of cyclic AMP receptor proteins in growth, differentiation and suppression of malignancy: New approaches to therapy. Cancer Res 50:7093, 1990
19. Lange-Carter CA, Vuillequez, JJ, Malkinson AM: 8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic amp-independent mechanism. Cancer Res 53:393, 1993
20. Vintermyr OK, Boe R, Brunstugun OT, Maronde E, Aakvaag A, Doskeland SO: Cyclic adenosine monophosphate (cAMP) analogs 8-Cl-and 8-NH2-cAMP induce cell death independently of cAMP kinase-mediate inhibition of the G1/S transition in mammary carcinoma cells (MCF-7). Endocrinology 136:2513, 1995
21. Taylor CW, Yeoman LC: Inhibition of colon tumor cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloroadenosine. Anticancer Drugs 3:485, 1992
22. Langeveld CH, Jongenelen CA, Theeuwes JW, Baak JP, Heimans JJ, Stoof JC, Peters GJ: The antiproliferative effect of 8-chloroadenosine, an active metabolite of 8-chloro-cyclic adenosine monophosphate, and disturbances in nucleic acid synthesis and cell cycle kinetics. Biochem Pharmacol 53:141, 1997
23. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS: Role of IκBα in mediation of immunosuppression by glucocorticoids. Science 270:283, 1995
24. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M: Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IKB synthesis. Science 270:286, 1995
25. Ludwig H, Nachbaur DM, Fritz E, Krainer M, Huber H: Interleukin-6 is a prognostic factor in multiple myeloma. Blood 77:2794, 1991
26. Cummings J, Langdon SP, Ritchie AA, Burns DJ, Mackay J, Stockman P, Leonard RCF, Miller WR: Pharmacokinetics, metabolism, and tumour disposition of 8-chloroadenosine 3′,5′-monophosphate in breast cancer patients and xenograft bearing mice. Ann Oncol 7:291, 1996