8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells

Biochemical Pharmacology

Volumn 72, Issue 5, 2006, Pages 541-550

  Gu, Yan Yan ^a   Zhang, Hong Yu ^a   Zhang, Hai Jun ^a   Li, Shu Yan ^a   Ni, Ju Hua ^a   Jia, Hong Ti ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

8 Chloro adenosine; Actin polymerization; G F actin ratio; G2 M arrest; Human lung cancer cell

Indexed keywords

8 CHLOROADENOSINE; ADENOSINE DERIVATIVE; ANTINEOPLASTIC AGENT; DEOXYRIBONUCLEASE I; F ACTIN; G ACTIN; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL SHAPE; CELL SIZE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ASSAY; ENZYME INHIBITION; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; LIGHT SCATTERING; LUNG CANCER; MICROFILAMENT; MITOSIS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; TARGET CELL;

2-CHLOROADENOSINE; ACTINS; BIOPOLYMERS; BLOTTING, WESTERN; CELL DIVISION; CELL SEPARATION; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 33746736820     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.05.026     Document Type: Article

References (38)

1. Lodish H, Berk A, Zipursky SL, Matsudaira P, Baltimore D, Darnell J. Mol Cell Biol. 4th ed New York: Scientific American Books; 2000.
2. Jordan M.A., and Wilson L. Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr Opin Cell Biol 10 (1998) 123-130
3. Lew D.J. Cell-cycle checkpoints that ensure coordination between nuclear, and cytoplasmic events in Saccharomyces cerevisiae. Curr Opin Genet Dev 10 (2000) 47-53
4. Rupe I., Webb B.A., Mak A., and Young P.G. G2/M arrest caused by actin disruption is a manifestation of the cell size checkpoint in fission yeast. Mol Biol Cell 12 (2001) 3892-3903
5. Gordon S.R., Climie M., and Hitt A.L. 5-Fluorouracil interferes with actin organization, stress fiber formation and cell migration in corneal endothelial cells during wound repair along the natural basement membrane. Cell Motil Cytoskeleton 62 (2005) 244-258
6. Lu Q.Y., Jin Y.S., Zhang Q., Zhang Z., Heber D., Go V.L., et al. Ganoderma lucidum extracts inhibit growth and induce actin polymerization in bladder cancer cells in vitro. Cancer Lett 216 (2004) 9-20
7. Bing W., Razzaq A., Sparrow J., and Marston S. Tropomyosin and troponin regulation of wild type and E93K mutant actin filaments from Drosophila flight muscle. J Biol Chem 273 (1998) 15016-15021
8. Tortora G., Pepe S., Yokozaki H., Meissner S., and Cho-Chung Y.S. Cooperative effect of 8-Cl-cAMP and rhGM-CSF on the differentiation of HL-60 human leukemia cells. Biochem Biophys Res Commun 177 (1991) 1133-1140
9. Halgren R.G., Traynor A.E., Pillay S., Zell J.L., Heller K.F., Krett N.L., et al. 8Cl-cAMP cytotoxicity in both steroid sensitive and insensitive multiple myeloma cell lines is mediated by 8Cl-Adenosine. Blood 92 (1998) 2893-2898
10. Langeveld C.H., Jongenelen C.A., Heimans J.J., and Stoof J.C. Growth inhibition of human glioma cells induced by 8-chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3′:5′-monophosphate. Cancer Res 52 (1992) 3994-3999
11. Ally S., Clair T., Katsaros D., Tortora G., Yokozaki H., Finch R.A., et al. Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate. Cancer Res 49 (1989) 5650-5655
12. Rohlff C., Clair T., and Cho-Chung Y.S. 8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. J Biol Chem 268 (1993) 5774-5782
13. Kim S.N., Ahn Y.H., Kim S.G., Park S.D., Cho-Chung Y.S., and Hong S.H. 8-Cl-cAMP induces cell cycle-specific apoptosis in human cancer cells. Int J Cancer 93 (2001) 33-41
14. Grbovic O., Jovic V., Ruzdijic S., Pejanovic V., Rakic L., and Kanazir S. 8-Cl-cAMP affects glioma cell-cycle kinetics and selectively induces apoptosis. Cancer Invest 20 (2002) 972-982
15. Taylor C.W., and Yeoman L.C. Inhibition of colon tumor cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine. Anticancer Drugs 3 (1992) 485-491
16. Carlson C.C., Chinery R., Burnham L.L., and Dransfield D.T. 8-Cl-adenosine-induced inhibition of colorectal cancer growth in vitro and in vivo. Neoplasia 2 (2000) 441-448
17. Gandhi V., Ayres M., Halgren R.G., Krett N.L., Newman R.A., and Rosen S.T. 8-Chloro-cAMP and 8-Chloro-adenosine act by the same mechanism in multiple myeloma cells. Cancer Res 61 (2001) 5474-5479
18. Stellrecht C.M., Rodriguez Jr. C.O., Ayres M., and Gandhi V. RNA-directed actions of 8-Chloro-adenosine in multiple myeloma cells. Cancer Res 63 (2003) 7968-7974
19. Fassina G., Aluigi M.G., Gentleman S., Wong P., Cai T., Albini A., et al. The cAMP analog 8-Cl-cAMP inhibits growth and induces differentiation and apoptosis in retinoblastoma cells. Int J Cancer 72 (1997) 1088-1094
20. Lange-Carter C.A., Vuillequez J.J., and Malkinson A.M. 8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down-regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic AMP-independent mechanism. Cancer Res 53 (1993) 393-400
21. Robbins S.K., Houlbrook S., Priddle J.D., and Harris A.L. 8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs. Cancer Chemother Pharmacol 48 (2001) 451-458
22. Chen L.S., and Sheppard T.L. Synthesis and hybridization properties of RNA containing 8-chloroadenosine. Nucleosides Nucleotides Nucleic Acids 21 (2002) 599-617
23. Chen L.S., and Sheppard T.L. Chain termination and inhibition of Saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogs. J Biol Chem 279 (2004) 40405-40411
24. Zhang H.-Y., Gu Y.-Y., Li Z.-G., Jia Y.-H., Yuan L., Li S.-Y., et al. Exposure of human lung cancer cells to 8-chloro-adenosine induces G2/M arrest and mitotic catastrophe. Neoplasia 6 (2004) 802-812
25. Yamazaki Y., Tsuruga M., Zhou D., Fujita Y., Shang X., Dang Y., et al. Cytoskeletal disruption accelerates caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis. Exp Cell Res 259 (2000) 64-78
26. Blader I.J., Cope M.J.V., Jackson T.R., Profit A.A., Greenwood A.F., Drubin D.G., et al. GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro. Mol Biol Cell 10 (1999) 581-596
27. Heacock C.S., and Bamburg J.R. The quantitation of G- and F-actin in cultured cells. Anal Biochem 135 (1983) 22-36
28. Bonder E.M., and Mooseker M.S. Cytochalasin B slows but does not prevent monomer addition at the barbed end of the actin filament. J Cell Biol 102 (1986) 282-288
29. Morris A., and Tannenbaum J. Cytochalasin D does not produce net depolymerization of actin filaments in HEp-2 cells. Nature 287 (1980) 637-639
30. Feldner J.C., and Brandt B.H. Cancer cell motility-on the road from c-erbB-2 receptor steered signaling to actin reorganization. Exp Cell Res 272 (2002) 93-108
31. Edwards D.C., Sanders L.C., Bockoch G.M., and Gill G.N. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signaling to actin cytoskeletal dynamics. Nat Cell Biol 1 (1999) 253-259
32. Weihing R.R. Cytochalasin B inhibits actin-related gelatin of Hela cell extracts. J Cell Biol 71 (1976) 303-307
33. Wessells N.K., Spooner B.S., Ash J.F., Bradley M.O., Luduena M.A., Taylor E.L., et al. Microfilaments in cellular and developmental processes. Science 171 (1971) 135-143
34. Baatout S., Chatelain B., Staquet P., Symann M., and Chatelain C. Induction and enhancement of normal human megakaryocyte polyploidization are concomitant with perturbation in the actin metabolism. Eur J Clin Invest 28 (1998) 845-855
35. Goode B.L., Drubin D.G., and Barnes G. Functional cooperation between the microtubule and actin cytoskeletons. Curr Opin Cell Biol 12 (2000) 63-71
36. Yarm F., Sagot I., and Pellman D. The social life of actin and microtubules: interaction versus cooperation. Curr Opin Microbiol 4 (2001) 696-702
37. Ahn Y.H., Jung J.M., and Hong S.H. 8-Cl-cAMP and its metabolite, 8-Cl-adenosine induce growth inhibition in mouse fibroblast DT cells through the same pathways; protein kinase C activation and cyclin B downregulation. J Cell Physiol 201 (2004) 277-285
38. Ahn Y.H., Jung J.M., and Hong S.H. 8-Chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells. Cancer Res 65 (2005) 4896-5901