FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow

European Journal of Immunology

Volumn 38, Issue 12, 2008, Pages 3290-3303

  Fujii, Toshimitsu ^a   Tomita, Takayuki ^a   Kanai, Takanori ^a,b   Nemoto, Yasuhiro ^a   Totsuka, Teruji ^a   Sakamoto, Naoya ^a   Nakamura, Tetsuya ^a   Tsuchiya, Kiichiro ^a   Okamoto, Ryuichi ^a   Watanabe, Mamoru ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chronic colitis; Colitogenic CD4+ T cells; FTY720; Inflammatory bowel disease; Mucosal immunity

Indexed keywords

FINGOLIMOD; CYTOKINE; DRUG DERIVATIVE; LYMPHOTOXIN; PROPANEDIOL DERIVATIVE; SPHINGOSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL MIGRATION; CELL TRANSPORT; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENETIC TRANSFECTION; LYMPHOCYTOPENIA; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; SINGLE DRUG DOSE; SPLEEN; SPLENECTOMY; T LYMPHOCYTE ACTIVATION; ANIMAL; APOPTOSIS; BIOSYNTHESIS; BONE MARROW; C57BL MOUSE; CELL MOTION; CYTOLOGY; DRUG EFFECT; GENETICS; IMMUNOLOGY; LYMPHADENECTOMY; LYMPHOID TISSUE; METABOLISM; PATHOLOGY;

ANIMALS; APOPTOSIS; BONE MARROW; CD4-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; COLITIS; CYTOKINES; LYMPH NODE EXCISION; LYMPHOID TISSUE; LYMPHOTOXIN-ALPHA; MICE; MICE, INBRED C57BL; PROPYLENE GLYCOLS; SPHINGOSINE; SPLENECTOMY;

EID: 59749098334     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200838359     Document Type: Article

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