FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes

Journal of Cardiovascular Pharmacology

Volumn 35, Issue 3, 2000, Pages 410-416

  Kitabayashi, Hiroshi ^a   Isobe, Mitsuaki ^a,b   Watanabe, Noboru ^a   Suzuki, Jun Ichi ^a   Yazaki, Yoshikazu ^a   Sekiguchi, Morie ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

FTY720; Immunotherapy; Lymphocyte; Myocarditis; Rat

Indexed keywords

FINGOLIMOD; FREUND ADJUVANT; INTERLEUKIN 2; MYOSIN; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFECT; DRUG STRUCTURE; GIANT CELL; HISTOPATHOLOGY; IMMUNOMODULATION; IMMUNOTHERAPY; LYMPHOCYTE COUNT; MALE; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN CELL; T LYMPHOCYTE;

ANALYSIS OF VARIANCE; ANIMALS; AUTOIMMUNE DISEASES; BODY WEIGHT; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAPERITONEAL; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; MYOCARDITIS; ORGAN SIZE; PROPYLENE GLYCOLS; RATS; RATS, INBRED LEW; SPHINGOSINE; TACROLIMUS;

EID: 0034002825     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200003000-00010     Document Type: Article

References (2)

1. Zee-Cheng CS, Tsai CC, Palmer DC, Codd JE, Pennington DG, Williams GA. High incidence of myocarditis by endomyocardial biopsy in patients with idiopathic congestive cardiomyopathy. J Am Coll Cardiol 1984;3:63-70.
2. Parrillo JE, Aretz HT, Palacios I, Fallon JT, Block PC. The results of transvenous endomyocardial biopsy can frequently be used to diagnose myocardial diseases in patients with idiopathic heart failure: endomyocardial biopsies in 100 consecutive patients revealed a substantial incidence of myocarditis. Circulation 1984;69:93-101.