Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis

Journal of the American College of Cardiology

Volumn 37, Issue 6, 2001, Pages 1713-1718

  Stabile, Giuseppe ^a   De Simone, Antonio ^a   Turco, Pietro ^a   La Rocca, Vincenzo ^a   Nocerino, Pasquale ^a   Astarita, Costantino ^b   Maresca, Francesco ^b   De Matteis, Carmine ^c   Di Napoli, Tommaso ^d   Stabile, Eugenio ^e   Vitale, Dino Franco ^f  

^a Laboratorio di Elettrofisiologia   (Italy)

^b Ospedale Civile di Sorrento   (Italy)

^c Ospedale Civile di Arienzo   (Italy)

^d Day Hospital Di Oncologia   (Italy)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f Centro Medico di Telese   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; FINGOLIMOD; GAMMA INTERFERON; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 12; INTERLEUKIN 2; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFICACY; ENCEPHALOMYOCARDITIS VIRUS; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; TREATMENT OUTCOME; VIRUS LOAD; VIRUS MYOCARDITIS; VIRUS REPLICATION;

ACUTE DISEASE; ANIMALS; CARDIOVIRUS INFECTIONS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ENCEPHALOMYOCARDITIS VIRUS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-2; MALE; MICE; MICE, INBRED DBA; MYOCARDITIS; NITRIC OXIDE; PROPORTIONAL HAZARDS MODELS; PROPYLENE GLYCOLS; SEVERITY OF ILLNESS INDEX; SPHINGOSINE; SURVIVAL ANALYSIS; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035038806     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(01)01204-9     Document Type: Article

References (42)

1. From myocarditis to cardiomyopathy: Mechanisms of inflammation and cell death: Learning from the past for the future
2. Molecular and immune mechanisms in the pathogenesis of cardiomyopathy - Role of viruses, cytokines, and nitric oxide
3. Coxsackievims B-3 myocarditis in Balb/c mice. Evidence for autoimmunity to myocyte antigens
4. Effects of prednisolone on acute viral myocarditis in mice
5. Coxsackievims B3 infection leads to cell death of cardiac myocytes
6. Therapy with cyclosporine in experimental murine myocarditis with encephalomyocarditis virus
7. The effects of cyclosporine on acute murine coxsackie B3 myocarditis
8. Treatment of experimental routine coxsackie B3 myocarditis
9. Animal models: Pathological findings and therapeutic considerations
10. A clinical trial of immunosuppressive therapy for myocarditis
11. Simple compounds, 2-substituted-2-amino-1, 3-propanodiols have potent immunosuppressive activity
12. Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1, 3-propanodiols: Discovery of a novel immunosuppressant, FTY720
13. Immunosuppressants: Cellular and molecular mechanisms of action
14. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing
15. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L-positive T cells in Peyer's patches by FTY720-induced lymphocyte homing
16. Analysis of the mode of action of a novel immunosuppressant FTY720 in mice
17. FTY720, a novel immunosuppressant possessing unique mechanisms: I. Prolongation of skin allograft survival and synergistic effect in combination with cydosporin in rats
18. A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation
19. FTY720: Mechanisms of action and its effect on organ transplantation
20. FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantation
21. FTY720 suppresses immune response by modulating G-protein coupled receptors on lymphocytes resulting in altered lymphocyte homing
22. An experimental model for congestive heart failure after encephalomyocarditis virus myocarditis in mice
23. Therapeutic effect of antitumor necrosis factor-alpha antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus
24. Treatment of experimental viral myocarditis with interleukin-10
25. Pimobendan inhibits the production of proinfiammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis
26. Sample pretreatment with nitrate reductase and glucose-6-phosphate dehydrogenase quantitatively reduces nitrate while avoiding interference by NADP+ when the Griess reaction is used to assay for nitrite
27. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo
28. Protective role of interleukin-12 in viral myocarditis
29. Pathogenesis and preventive and therapeutic trials in an animal model of dilated cardiomyopathy induced by a virus
30. Mechanism of action of cyclosporin A in vivo. I. Cyclosporin A fails to inhibit T lymphocyte activation in response to alloantigens
31. Quantitating immunosuppression. Estimating the 50% inhibitory concentration for in vivo cyclosporine in mice
32. FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes
33. An immunosuppressant compound, FK-506, prevents the progression of autoimmune myocarditis in rats
34. FKS06 therapy of experimental autolmmune myocarditis after onset of the disease
35. A double-blind placebo-controlled trial of low-dose ganciclovir to prevent cytomegalovirus disease after heart transplantation
36. Immunosuppressive and immunomodulatory treatment for myocarditis
37. Functional diversity of helper T lymphocytes
38. Therapeutic actions of cyclosporine and anti-tumor necrosis factor alpha in collagen-induced arthritis and the effect of combination therapy
39. Persistent expression of cytokine in the chronic stage of viral myocarditis in mice
40. Differential modulation of cytokine production by drugs: Implications for therapy in heart failure
41. Inotropic agents differentially inhibit the induction of nitric oxide synthase by endotoxin in cultured macrophages
42. The use of cytokine inhibitors. A new therapeutic insight into heart failure