Nonesterified fatty acid exposure activates protective and mitogenic pathways in vascular smooth muscle cells by alternate signaling pathways

Metabolism: Clinical and Experimental

Volumn 58, Issue 3, 2009, Pages 319-327

  Schauer, Irene E ^a,b   Reusch, Jane E B ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; FATTY ACID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE;

ARTICLE; ATHEROSCLEROSIS; CELL PROTECTION; ENZYME ACTIVATION; FATTY ACID BLOOD LEVEL; HOMEOSTASIS; HUMAN; IN VITRO STUDY; METABOLIC STRESS; MITOGENESIS; PRIORITY JOURNAL; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; CATTLE; CELL DIVISION; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FATTY ACIDS, NONESTERIFIED; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 59649086870     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2008.10.003     Document Type: Article

References (50)

1. Ross R. The pathogenesis of atherosclerosis-an update. N Engl J Med 314 (1986) 488-500
2. Libby P. Vascular biology of atherosclerosis: overview and state of the art. Am J Cardiol 91 (2003) 3A-6A
3. Carlsson M., Wessman Y., Almgren P., and Groop L. High levels of nonesterified fatty acids are associated with increased familial risk of cardiovascular disease. Arterioscler Thromb Vasc Biol 20 (2000) 1588-1594
4. Oram J.F., and Bornfeldt K.E. Direct effects of long-chain non-esterified fatty acids on vascular cells and their relevance to macrovascular complications of diabetes. Front Biosci 9 (2004) 1240-1253
5. Askari B., Renard C.B., and Bornfeldt K.E. Regulation of smooth muscle cell accumulation in diabetes-accelerated atherosclerosis. Histol Histopathol 17 (2002) 1317-1328
6. Lu G., Greene E.L., Nagai T., and Egan B.M. Reactive oxygen species are critical in the oleic acid-mediated mitogenic signaling pathway in vascular smooth muscle cells. Hypertension 32 (1998) 1003-1010
7. Lu G., Meier K.E., Jaffa A.A., Rosenzweig S.A., and Egan B.M. Oleic acid and angiotensin II induce a synergistic mitogenic response in vascular smooth muscle cells. Hypertension 31 (1998) 978-985
8. Lu G., Morinelli T.A., Meier K.E., Rosenzweig S.A., and Egan B.M. Oleic acid-induced mitogenic signaling in vascular smooth muscle cells. A role for protein kinase C. Circ Res 79 (1996) 611-618
9. Rao G.N., Alexander R.W., and Runge M.S. Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells. J Clin Invest 96 (1995) 842-847
10. Karman R.J., Gupta M.P., Garcia J.G., and Hart C.M. Exogenous fatty acids modulate the functional and cytotoxic responses of cultured pulmonary artery endothelial cells to oxidant stress. J Lab Clin Med 129 (1997) 548-556
11. Sohma R., Takahashi M., Takada H., and Kuwayama H. Protective effect of n-3 polyunsaturated fatty acid on primary culture of rat hepatocytes. J Gastroenterol Hepatol 22 (2007) 1965-1970
12. Agarwal A., Shiraishi F., Visner G.A., and Nick H.S. Linoleyl hydroperoxide transcriptionally upregulates heme oxygenase-1 gene expression in human renal epithelial and aortic endothelial cells. J Am Soc Nephrol 9 (1998) 1990-1997
13. Kuratko C.N., and Constante B.J. Linoleic acid and tumor necrosis factor-alpha increase manganese superoxide dismutase activity in intestinal cells. Cancer Lett 130 (1998) 191-196
14. Wright M.M., Schopfer F.J., Baker P.R., Vidyasagar V., Powell P., Chumley P., et al. Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression. Proc Natl Acad Sci U S A 103 (2006) 4299-4304
15. Meilhac O., Zhou M., Santanam N., and Parthasarathy S. Lipid peroxides induce expression of catalase in cultured vascular cells. J Lipid Res 41 (2000) 1205-1213
16. Kronke G., Bochkov V.N., Huber J., Gruber F., Bluml S., Furnkranz A., et al. Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein. J Biol Chem 278 (2003) 51006-51014
17. Madamanchi N.R., Moon S.K., Hakim Z.S., Clark S., Mehrizi A., Patterson C., et al. Differential activation of mitogenic signaling pathways in aortic smooth muscle cells deficient in superoxide dismutase isoforms. Arterioscler Thromb Vasc Biol 25 (2005) 950-956
18. Reusch J.E., and Watson P.A. Loss of CREB regulation of vascular smooth muscle cell quiescence in diabetes. Rev Endocr Metab Disord 5 (2004) 209-219
19. Jhala U.S., Canettieri G., Screaton R.A., Kulkarni R.N., Krajewski S., Reed J., et al. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev 17 (2003) 1575-1580
20. Reusch J.E., and Klemm D.J. Inhibition of cAMP-response element-binding protein activity decreases protein kinase B/Akt expression in 3T3-L1 adipocytes and induces apoptosis. J Biol Chem 277 (2002) 1426-1432
21. Finkbeiner S. CREB couples neurotrophin signals to survival messages. Neuron 25 (2000) 11-14
22. Pugazhenthi S., Miller E., Sable C., Young P., Heidenreich K.A., Boxer L.M., et al. Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein. J Biol Chem 274 (1999) 27529-27535
23. Pugazhenthi S., Nesterova A., Sable C., Heidenreich K.A., Boxer L.M., Heasley L.E., et al. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem 275 (2000) 10761-10766
24. Watson P.A., Vinson C., Nesterova A., and Reusch J.E. Content and activity of cAMP response element-binding protein regulate platelet-derived growth factor receptor-alpha content in vascular smooth muscles. Endocrinology 143 (2002) 2922-2929
25. Watson P.A., Nesterova A., Burant C.F., Klemm D.J., and Reusch J.E. Diabetes-related changes in cAMP response element-binding protein content enhance smooth muscle cell proliferation and migration. J Biol Chem 276 (2001) 46142-46150
26. Garat C.V., Fankell D., Erickson P.F., Reusch J.E., Bauer N.N., McMurtry I.F., et al. Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells. Mol Cell Biol 26 (2006) 4934-4948
27. Jambal P., Masterson S., Nesterova A., Bouchard R., Bergman B., Hutton J.C., et al. Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells. J Biol Chem 278 (2003) 23055-23065
28. Pugazhenthi S., Nesterova A., Jambal P., Audesirk G., Kern M., Cabell L., et al. Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons. J Neurochem 84 (2003) 982-996
29. Klemm D.J., Watson P.A., Frid M.G., Dempsey E.C., Schaack J., Colton L.A., et al. cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration. J Biol Chem 276 (2001) 46132-46141
30. Ellmerer M., Schaupp L., Brunner G.A., Sendlhofer G., Wutte A., Wach P., et al. Measurement of interstitial albumin in human skeletal muscle and adipose tissue by open-flow microperfusion. Am J Physiol Endocrinol Metab 278 (2000) E352-E356
31. Askari B., Carroll M.A., Capparelli M., Kramer F., Gerrity R.G., and Bornfeldt K.E. Oleate and linoleate enhance the growth-promoting effects of insulin-like growth factor-I through a phospholipase D-dependent pathway in arterial smooth muscle cells. J Biol Chem 277 (2002) 36338-36344
32. Greene E.L., Lu G., Zhang D., and Egan B.M. Signaling events mediating the additive effects of oleic acid and angiotensin II on vascular smooth muscle cell migration. Hypertension 37 (2001) 308-312
33. Kanda H., and Miura M. Regulatory roles of JNK in programmed cell death. J Biochem (Tokyo) 136 (2004) 1-6
34. Diep Q.N., Touyz R.M., and Schiffrin E.L. Docosahexaenoic acid, a peroxisome proliferator-activated receptor-alpha ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension 36 (2000) 851-855
35. Parmentier J.H., Zhang C., Estes A., Schaefer S., and Malik K.U. Essential role of PKC-zeta in normal and angiotensin II-accelerated neointimal growth after vascular injury. Am J Physiol Heart Circ Physiol 291 (2006) H1602-H1613
36. Raben A., Holst J.J., Madsen J., and Astrup A. Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high-fat diet in normal-weight never-obese and postobese women. Am J Clin Nutr 73 (2001) 177-189
37. Reaven G.M., Hollenbeck C., Jeng C.Y., Wu M.S., and Chen Y.D. Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes 37 (1988) 1020-1024
38. Yuan L., Ziegler R., and Hamann A. Chronic hyperinsulinism induced down-regulation of insulin post-receptor signaling transduction in Hep G2 cells. J Huazhong Univ Sci Technolog Med Sci 22 (2002) 313-316
39. Wallukat G. The beta-adrenergic receptors. Herz 27 (2002) 683-690
40. Allen T.R., Krueger K.D., Hunter III W.J., and Agrawal D.K. Evidence that insulin-like growth factor-1 requires protein kinase C-epsilon, PI3-kinase and mitogen-activated protein kinase pathways to protect human vascular smooth muscle cells from apoptosis. Immunol Cell Biol 83 (2005) 651-667
41. Leitges M., Mayr M., Braun U., Mayr U., Li C., Pfister G., et al. Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice. J Clin Invest 108 (2001) 1505-1512
42. Li P.F., Maasch C., Haller H., Dietz R., and von Harsdorf R. Requirement for protein kinase C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells. Circulation 100 (1999) 967-973
43. Ryer E.J., Sakakibara K., Wang C., Sarkar D., Fisher P.B., Faries P.L., et al. Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms. J Biol Chem 280 (2005) 35310-35317
44. Yamaguchi H., Igarashi M., Hirata A., Sugae N., Tsuchiya H., Jimbu Y., et al. Altered PDGF-BB-induced p38 MAP kinase activation in diabetic vascular smooth muscle cells: roles of protein kinase C-delta. Arterioscler Thromb Vasc Biol 24 (2004) 2095-2101
45. Fan C.Y., Katsuyama M., and Yabe-Nishimura C. PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: possible involvement of PKCdelta in vascular hypertrophy. Biochem J 390 Pt 3 (2005) 761-767
46. Esposito K., Marfella R., Ciotola M., Di Palo C., Giugliano F., Giugliano G., et al. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA 292 (2004) 1440-1446
47. Hirafuji M., Machida T., Hamaue N., and Minami M. Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid. J Pharmacol Sci 92 (2003) 308-316
48. Holub D.J., and Holub B.J. Omega-3 fatty acids from fish oils and cardiovascular disease. Mol Cell Biochem 263 (2004) 217-225
49. Stefan N., Wahl H.G., Fritsche A., Haring H., and Stumvoll M. Effect of the pattern of elevated free fatty acids on insulin sensitivity and insulin secretion in healthy humans. Horm Metab Res 33 (2001) 432-438
50. Borkman M., Storlien L.H., Pan D.A., Jenkins A.B., Chisholm D.J., and Campbell L.V. The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N Engl J Med 328 (1993) 238-244