Chronic hyperinsulinism induced down-regulation of insulin post-receptor signaling transduction in Hep G2 cells

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 22, Issue 4, 2002, Pages 313-316

  Yuan, Li ^a,b   Ziegler, Reinhard ^a   Hamann, Andreas ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Insulin; Insulin resistance; Insulin signaling transduction

Indexed keywords

CELLS; HUMAN ENGINEERING; PROTEINS;

CHRONIC INSULIN; PROTEIN LEVEL; SIGNALING TRANSDUCTION;

INSULIN;

INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; PHOSPHOPROTEIN;

ARTICLE; CELL CULTURE; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; HYPERINSULINISM; INSULIN RESISTANCE; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CARCINOMA, HEPATOCELLULAR; DOWN-REGULATION; HUMANS; HYPERINSULINISM; INSULIN RESISTANCE; LIVER NEOPLASMS; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 3042828439     PISSN: 0257716X     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02896773     Document Type: Article

References (14)

1. White M F, Kahn C R. The insulin signaling system. J Biol Chem, 1994,269:1
2. White M F. The insulin signaling system and the IRS proteins. Diabetologia, 1997,40(Suppl 2):S2
3. Backer J M, Myers M G, Shoelsen S E et al. The phosphatidylinositol 3-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J, 1992, 11:3469
4. Lavan B E, Kuhne M R, Garner C W et al. The association of insulin-elicited phosphotyrosine proteins with src homology 2 domains. J Biol Chem, 1992, 267: 11631
5. Yonezawa K, Ueda H, Hara K et al. Insulin-dependent formation of a complex containing an 85 kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphory-tated insulin receptor substrate 1. J Biol Chem, 1992, 267:25958
6. Bergman R N. New concepts in extracellular signaling for insulin action: the single gateway hypothesis. Recent Prog Horm Res, 1997,52:359
7. Bjornholm M, Kawano Y, Lehtihet M et al. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes, 1997,46:524
8. Kapeller R, Chen K S, Yoakim M et al. Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. Mol Endocrinol, 1991,5:769
9. Treadway J L, Whittaker J, Pessin J E. Regulation of the insulin receptor kinase by hyperinsulinism. J Biol Chem, 1989,264:15136
10. Saad M J, Araki E, Miralpeix M et al. Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. J Clin Invest, 1992, 90:1839
11. Rice K M, Lienhard G E, Garner C W. Regulation of the expression of pp160, a putative insulin receptor signal protein, by insulin, dexamethasone, and 1-methyl-3- isobutylxanthine in 3T3-L1 adipocytes. J Biol Chem, 1992,267:10 163.
12. Saad M J, Folli F, Araki E et al. Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone. Mol Endocrinol, 1994,8:545
13. Kanety H, Feinstein R, Papa M Z et al. Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1. J Biol Chem, 1995,270:23780
14. Hotamisligil G S, Spiegelman B M. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes, 1994,43:1271