Measurements of the BK Ca channel's high-affinity Ca 2+ binding constants: Effects of membrane voltage

Journal of General Physiology

Volumn 132, Issue 5, 2008, Pages 491-505

  Sweet, Tara Beth ^a   Cox, Daniel H ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL; CALCIUM; MUTANT PROTEIN;

ARTICLE; BINDING AFFINITY; CALCIUM BINDING; CELL MEMBRANE CONDUCTANCE; CHANNEL GATING; DOSE RESPONSE; ELECTROPHYSIOLOGY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; ANIMAL; BINDING SITE; CALCIUM SIGNALING; CELL LINE; CELL MEMBRANE POTENTIAL; ELECTRICITY; GENETICS; KINETICS; METABOLISM; MOUSE; PATCH CLAMP; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; ULTRASTRUCTURE;

ANIMALS; BINDING SITES; CALCIUM; CALCIUM SIGNALING; CELL LINE, TRANSFORMED; ELECTRICITY; HUMANS; ION CHANNEL GATING; KINETICS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MEMBRANE POTENTIALS; MICE; MUTANT PROTEINS; PATCH-CLAMP TECHNIQUES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 59449101655     PISSN: 00221295     EISSN: 15407748     Source Type: Journal    
DOI: 10.1085/jgp.200810094     Document Type: Article

References (42)

1. Ca channel's Ca2+ sensitivity is enhanced by its betal sub- unit.J. Gen. Physiol. 126:393-412.
2. Bao, L., A.M. Rapin, E.C. Holmstrand, and D.H. Cox. 2002. Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensi- tivityJ. Gen. Physiol. 120:173-189.
3. Ca channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.J Gen. Physiol. 123:475-489.
4. Barrett, J.N., K.L. Magleby, and B.S. Pallotta. 1982. Properties of sin- gle calcium-activated potassium channels in cultured rat muscle. J. Physiol. 331:211-230.
5. Bian, S., I. Favre, and E. Moczydlowski. 2001. Ca2+f-binding activ- ity of a COOH-terminal fragment of the Drosophila BK channel involved in Ca2+-dependent activation. Proc. Natl. Acad. Sci. USA. 98:4776-4781.
6. Brenner, R., G.J. Perez, A.D. Bonev, D.M. Eckman, J.C. Kosek, S.W. Wiler, A.J. Patterson, M.T. Nelson, and R.W. Aldrich. 2000. Vasoregulation by the betal subunit of the calcium-activated potassium channel. Nature. 407:870-876.
7. Butler, A., S. Tsunoda, D.P McCobb, A. Wei, and L. Salkoff. 1993. mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. Science. 261:221-224.
8. Cox, D.H, and RW. Aldrich. 2000. Role of the betal subunit in large-conductance Ca(2+)-activated K(+) channel gating energet- ics. Mechanisms of enhanced Ca(2+) sensitivity. J. Gen. Physiol. 116:411-432.
9. Cox, D.H, J. Cui, and R.W. Aldrich. 1997. Allosteric gating of a large conductance Ca-activated K+ channel. J Gen. Physiol. 110:257-281.
10. + channels.J Gen. Physiol. 109:647-673.
11. Diaz, L., P. Meera, J. Amigo, E. Stefani, O. Alvarez, L. Toro, and R Latorre. 1998. Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel. J Biol. Chem. 273: 32430-32436.
12. Hamill, O.P, A. Marty, E. Neher, B. Sakmann, and F.J. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current re- cording from cells and cell-free membrane patches. Pflugers Arch. 391:85-100.
13. Horrigan, EX, and R.W. Aldrich. 1999. Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+)./ Gen. Physiol. 114:305-336.
14. Horrigan, EX, and R.W. Aldrich. 2002. Coupling between voltage sensor activation, Ca2+ binding and channel opening in large con- ductance (BK) potassium channels.J Gen. Physiol. 120:267-305.
15. Horrigan, EX, and Z. Ma. 2008. Mg2+ enhances voltage sensor/ gate coupling in BK channels.J. Gen. Physiol. 131:13-32.
16. Horrigan, EX, J. Cui, and R.W. Aldrich. 1999. Allosteric voltage gat- ing of potassium channels I. Mslo ionic currents in the absence of Ca(2+)./ Gen. Physiol. 114:277-304.
17. Hu, H, L.R. Shao, S. Chavoshy, N. Gu, M. Trieb, R. Behrens, P. Laake, O. Pongs, H.G Knaus, O.P. Ottersen, and J.F. Storm. 2001. Presynaptic Ca2+-activated K+ channels in glutamatergic hippo- campal terminals and their role in spike repolarization and regu- lation of transmitter release.KJNeurosci. 21:9585-9597.
18. Jiang, Y., A. Pico, M. Cadene, B.T. Chait, and R. MacKinnon. 2001. Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron. 29:593-601.
19. Jiang, Y, A. Lee,J. Chen,M. Cadene, B.T. Chait, and R. MacKinnon. 2002. Crystal structure and mechanism of a calcium-gated potas- sium channel. Nature. 417:515-522.
20. Kim, H.J., H.H. Lim, S.H. Rho, L. Bao,J.H Lee, D.H. Cox, H. Kim, and C.S. Park. 2008. Modulation of the conductance- voltage relationship of the BK Ca channel by mutations at the putative flexible interface between two RCK domains. Biophys. J. 94:446-456.
21. Magleby, KL. 2003. Gating mechanism of BK (Slol) channels: so near, yet so far.J Gen. Physiol. 121:81-96.
22. McManus, O.B.,and K.L. Magleby. 1991. Accounting for the Ca(2+)- dependent kinetics of single large- conductance Ca(2+)-activated K+ channels in rat skeletal muscle.J. Physiol. 443:739-777.
23. Nelson, M.T., and J.M. Quayle. 1995. Physiological roles and prop- erties of potassium channels in arterial smooth muscle. Am. J. Physiol. 268:C799-C822.
24. Niu, X., and K.L. Magleby. 2002. Stepwise contribution of each sub- unit to the cooperative activation of BK channels by Ca2+. Proc. Natl. Acad. Sci. USA. 99:11441-11446.
25. Qian, X., and K.L. Magleby. 2003. Beta 1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, acti- vating mechanisms. Proc. Natl. Acad. Sci. USA. 100:10061-10066.
26. Qian, X., X. Niu, and K.L. Magleby. 2006. Intra- and intersubunit cooperativity in activation of BK channels by Ca2+.J. Gen. Physiol. 128:389-404.
27. Roberts, W.M., R.A.Jacobs, and A.J. Hudspeth. 1990. Colocalization of ion channels involved in frequency selectivity and synaptic transmission at presynaptic active zones of hair cells. J. Neurosci. 10:3664-3684.
28. Robitaille, R.E., M. Adler, and M.P. Charlton. 1993. Calcium chan- nels and calcium-gated potassium channels at the frog neuromus- cular junction.J. Physiol. (Paris). 87:15-24.
29. Rothberg, B.S., and K.L. Magleby. 1999. Gating kinetics of single large-conductance Ca2+-activated K+ channels in high Ca2+ suggest a two-tiered allosteric gating mechanism. J Gen. Physiol. 114:93-124 (published erratum appears in J Gen. Physiol. 1999. 114:337).
30. Rothberg, B.S., and K.L. Magleby. 2000. Voltage and Ca2+ activa- tion of single large-conductance Ca2+-activated K+ channels described by a two-tiered allosteric gating mechanism. J Gen. Physiol. 116:75-99.
31. Sah, RE., and M. McLachlan. 1992. Potassium currents contribut- ing to action potential repolarization and the afterhyperpolariza- tion in rat vagal motoneurons.J. Neurophysiol. 68:1834-1841.
32. Schreiber, M., and L. Salkoff. 1997. A novel calcium-sensing domain in the BK channel. Biophys.J. 73:1355-1363.
33. Schreiber, M., A. Yuan, and L. Salkoff. 1999. Transplantable sites con- fer calcium sensitivity to BK channels. Nat. Neurosci. 2:416-421.
34. Semenov, I., B. Wang, J.T. Herlihy, and R. Brenner. 2006. BK chan- nel betal-subunit regulation of calcium handling and constric- tion in tracheal smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol. 291:L802-L810.
35. Shi,J., G. Krishnamoorthy, Y.Yang, L. Hu, N. Chaturvedi, D. Harilal, J. Qin, and J. Cui. 2002. Mechanism of magnesium activation of calcium-activated potassium channels. Nature. 418:876-880.
36. Stefani, E., M. Ottolia, E Noceti, R. Olcese, M. Wallner, R. Latorre, and L. Toro. 1997. Voltage-controlled gating in a large conduc- tance Ca2+-sensitive K+channel (hslo). Proc. Natl. Acad. Sci. USA. 94:5427-5431.
37. Storm, J.F. 1987. Action potential repolarization and a fast after- hyperpolarization in rat hippocampal pyramidal cells. J. Physiol. 385:733-759.
38. Wang, Z., W.O. Saifee, M.L. Nonet, and L. Salkoff. 2001. SLO-1 potassium channels control quantal content of neurotransmit- ter release at the C. elegans neuromuscular junction. Neuron. 32:867-881.
39. Ca channels determined by a separable domain. Neuron. 13:671-681.
40. Xia, X.M., X. Zeng, and C.J. Lingle. 2002. Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature. 418:880-884.
41. Yang, X.C., and F. Sachs. 1989. Block of stretch-activated ion chan- nels in Xenopus oocytes by gadolinium and calcium ions. Science. 243:1068-1071.
42. Zeng, X.H., X.M. Xia, and C.J. Lingle. 2005. Divalent cation sen- sitivity of BK channel activation supports the existence of three distinct binding sites.J Gen. Physiol. 125:273-286.