Mg2+ enhances voltage sensor/gate coupling in BK channels

Journal of General Physiology

Volumn 131, Issue 1, 2008, Pages 13-32

  Horrigan, Frank T ^a   Ma, Zhongming ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; MAGNESIUM; MUTANT PROTEIN; CALCIUM;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM CELL LEVEL; CHANNEL GATING; CONTROLLED STUDY; ELECTRIC POTENTIAL; ENERGY TRANSFER; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; MEMBRANE CONDUCTANCE; MEMBRANE DEPOLARIZATION; MOLECULAR INTERACTION; NONHUMAN; PROTEIN DOMAIN; STEADY STATE; ANIMAL; BIOLOGICAL MODEL; CELL MEMBRANE; CYTOLOGY; ELECTRICITY; ELECTROPHYSIOLOGY; FEMALE; OOCYTE; PATCH CLAMP; PHYSIOLOGY; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

ALLOSTERIC REGULATION; ANIMALS; CALCIUM; CELL MEMBRANE; ELECTROPHYSIOLOGY; ELECTROSTATICS; FEMALE; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MAGNESIUM; MODELS, BIOLOGICAL; OOCYTES; PATCH-CLAMP TECHNIQUES; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

EID: 38049002536     PISSN: 00221295     EISSN: 00221295     Source Type: Journal    
DOI: 10.1085/jgp.200709877     Document Type: Article

References (46)

1. Armstrong, C.M., and F. Bezanilla. 1974. Charge movement associated with the opening and closing of the activation gates of the Na channels. J. Gen. Physiol. 63:533-552.
2. Avdonin, V., X.D. Tang, and T. Hoshi. 2003. Stimulatory action of internal protons on Slo1 BK channels. Biophys. J. 84:2969-2980.
3. Brayden, J.E., and M.T. Nelson. 1992. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science. 256:532-535.
4. Butler, A., S. Tsunoda, D.P. McCobb, A. Wei, and L. Salkoff. 1993. mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. Science. 261:221-224.
5. Campos, F.V., B. Chanda, B. Roux, and F. Bezanilla. 2007. Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel. Proc. Natl. Acad. Sci. USA. 104:7904-7909.
6. + channel. J. Gen. Physiol. 110:257-281.
7. + channels. Biochemistry. 39:15612-15619.
8. + channels. J. Gen. Physiol. 109:647-673.
9. + (hslo) channel from smooth muscle. J. Gen. Physiol. 107:399-407.
10. Faber, E.S., and P. Sah. 2003. Calcium-activated potassium channels: multiple contributions to neuronal function. Neuroscientist. 9:181-194.
11. 2+ also block. J. Gen. Physiol. 98:163-181.
12. Gupta, R.K., P. Gupta, and R.D. Moore. 1984. NMR studies of intracellular metal ions in intact cells and tissues. Annu. Rev. Biophys. Bioeng. 13:221-246.
13. Hamill, O.P., A. Marty, E. Neher, B. Sakmann, and F.J. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers. Arch. 391:85-100.
14. Herrington, J., and R.J. Bookman. 1995. Pulse Control. University of Miami Press, Miami, FL.
15. 2+. J. Gen. Physiol. 114:305-336.
16. 2+ binding and channel opening in large conductance (BK) potassium channels. J. Gen. Physiol. 120:267-305.
17. 2+. J. Gen. Physiol. 114:277-304.
18. Horrigan, F.T., S.H. Heinemann, and T. Hoshi. 2005. Heme regulates allosteric activation of the Slo1 BK channel. J. Gen. Physiol. 126:7-21.
19. + channels. Proc. Natl. Acad. Sci. USA. 100:10488-10493.
20. Hu, L., H. Yang, J. Shi, and J. Cui. 2006. Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels. J. Gen. Physiol. 127:35-49.
21. Jiang, Y., A. Lee, J. Chen, M. Cadene, B.T. Chait, and R. MacKinnon. 2002. Crystal structure and mechanism of a calcium-gated potassium channel. Nature. 417:515-522.
22. + channel and demonstration of its presence in the human BK channel. Neuron. 29:593-601.
23. Jiang, Z., M. Wallner, P. Meera, and L. Toro. 1999. Human and rodent MaxiK channel beta-subunit genes: cloning and characterization. Genomics. 55:57-67.
24. + channel. Science. 309:897-903.
25. Long, S.B., E.B. Campbell, and R. Mackinnon. 2005b. Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling. Science. 309:903-908.
26. + channels. J. Gen. Physiol. 120:663-676.
27. Ma, Z., X.J. Lou, and F.T. Horrigan. 2006. Role of charged residues in the S1-S4 voltage sensor of BK channels. J. Gen. Physiol. 127:309-328.
28. + channels. Biophys. J. 71:220-226.
29. 2+-activated potassium channel. Neuron. 42:745-756.
30. + channel. Neuron. 56:124-140.
31. Patton, C., S. Thompson, and D. Epel. 2004. Some precautions in using chelators to buffer metals in biological solutions. Cell Calcium. 35:427-431.
32. Romani, A., and A. Scarpa. 1992. Regulation of cell magnesium. Arch. Biochem. Biophys. 298:1-12.
33. + channel. Cell. 123:463-475.
34. + channels. J. Gen. Physiol. 118:589-606.
35. Shi, J., G. Krishnamoorthy, Y. Yang, L. Hu, N. Chaturvedi, D. Harilal, J. Qin, and J. Cui. 2002. Mechanism of magnesium activation of calcium-activated potassium channels. Nature. 418:876-880.
36. + channel (hslo). Proc. Natl. Acad. Sci. USA. 94:5427-5431.
37. Tang, X.D., R. Xu, M.F. Reynolds, M.L. Garcia, S.H. Heinemann, and T. Hoshi. 2003. Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature. 425:531-535.
38. 2+ with quin2. Methods Enzymol. 172:230-262.
39. Vergara, C., R. Latorre, N.V. Marrion, and J.P. Adelman. 1998. Calcium-activated potassium channels. Curr. Opin. Neurobiol. 8:321-329.
40. 2+-sensitive ion channels. Cell Calcium. 34:211-229.
41. Xia, X.M., X. Zeng, and C.J. Lingle. 2002. Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature. 418:880-884.
42. Yang, H., L. Hu, J. Shi, and J. Cui. 2006. Tuning magnesium sensitivity of BK channels by mutations. Biophys. J. 91:2892-2900.
43. 2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. Proc. Natl. Acad. Sci. USA. 104:18270-18275.
44. + channels. Cell. 126:1161-1173.
45. 2+-dependent gating of large conductance (BK) potassium channels. J. Gen. Physiol. 125:213-236.
46. 2+ through a nonselective, low affinity divalent cation site. J. Gen. Physiol. 118:607-636.