Modulation of the conductance-voltage relationship of the BKCa channel by mutations at the putative flexible interface between two RCK domains

Biophysical Journal

Volumn 94, Issue 2, 2008, Pages 446-456

  Kim, Hyun Ju ^a   Lim, Hyun Ho ^a   Rho, Seong Hwan ^a   Bao, Lin ^b   Lee, Ju Ho ^a   Cox, Daniel H ^b   Do, Han Kim ^a   Park, Chul Seung ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CALCIUM ION; GLYCINE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; POTASSIUM ION; CALCIUM; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM BINDING; CHANNEL GATING; CONDUCTANCE; CONTROLLED STUDY; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POTASSIUM CONDUCTANCE; PREDICTION; PROTEIN CONFORMATION; PROTEIN DOMAIN; SENSITIVITY ANALYSIS; STRUCTURE ANALYSIS; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; CHO CELL; CRICETULUS; DRUG EFFECT; ELECTRIC CONDUCTIVITY; GENETICS; HAMSTER; METABOLISM; PROTEIN TERTIARY STRUCTURE; RAT; STRUCTURE ACTIVITY RELATION; XENOPUS;

AMINO ACID SUBSTITUTION; ANIMALS; ASPARTIC ACID; CALCIUM; CHO CELLS; CRICETINAE; CRICETULUS; ELECTRIC CONDUCTIVITY; GLYCINE; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MODELS, BIOLOGICAL; MUTANT PROTEINS; MUTATION; PROTEIN STRUCTURE, TERTIARY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 38349027008     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.107.108738     Document Type: Article

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