Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-Jun activation

Molecules and Cells

Volumn 24, Issue 1, 2007, Pages 95-104

  Shim, Hye Young ^a   Park, Jong Hwa ^a   Paik, Hyun Dong ^a   Nah, Seung Yeol ^a   Kim, Darrick S H L ^b   Han, Ye Sun ^a  

^a Konkuk University   (South Korea)

^b CurXceL Corporation   (United States)

Author keywords

Acacetin; Apoptosis inducing factor; Bax; Bcl 2; c Jun; c Jun NH4 terminal kinase; Caspase; Cytochrome c; Mitochondrial membrane potential; Reactive oxygen species

Indexed keywords

ACACETIN; ACETYLCYSTEINE; APOPTOSIS INDUCING FACTOR; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; DNA FRAGMENT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1;

APOPTOSIS; ARTICLE; BREAST CANCER; CELL CYCLE G1 PHASE; CELL DEATH; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CASPASE 3; CASPASES; CELL LINE, TUMOR; FEMALE; FLAVONES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OLIGOPEPTIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 35048858737     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Adams, J. M. and Cory, S. (1998) The Bcl-2 protein family: arbiters of cell survival 1. Science 281, 1322-1326.
2. Banerjee, S., Zhang, Y., Ali, S., Bhuiyan, M., Wang, Z., et al. (2005) Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res. 65, 9064-9072.
3. Boege, F., Staub, T., Kehr, A., Boesenberg, C., Christiansen, K., et al. (1996) Selected novel flavonoids inhibit the DNA topoisomerase I. J. Biol. Chem. 271, 2262-2270.
4. Brown, K. (2002) Breast cancer chemoprevention: risk-benefit effects of the antioestrogen tamoxifen. Expert Opin. Drug Saf. 1, 253-267.
5. Chan, K. and Morris, G. J. (2006) Chemoprevention of breast cancer for women at high risk. Semin. Oncol. 33, 642-646.
6. Chen, Y. R., Meyer, C. F., and Tan, T. H. (1996) Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J. Biol. Chem. 271, 631-634.
7. 4-induced microsomal lipid peroxidation. Experientia 47, 195-199.
8. Corbiere, C., Liagre, B., Terro, F., and Beneytout, J. L. (2004) Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells. Cell Res. 14, 188-196.
9. Cryns, V. and Yuan, J. (1998) Proteases to die for. Genes Dev. 12, 1551-1570.
10. Ding W. X., Shen, H. M., and Ong, C. N. (2000) Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes. Hepatology 32, 547-555.
11. Doostdar, H., Burke, M. D., and Mayer, R. T. (2000) Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYPIA and CYP1B1. Toxicology 144, 31-38.
12. Duthie, S. J. and Dobson, V. L. (1999) Dietary flavonoids protect human colonocyte DNA from oxidative attract in vivo. Eur J. Nutr. 38, 28-34.
13. Fan, Y., Chen, H., Qiao, B., Luo, L., Ma, H., et al. (2007) Opposing effects of ERK and p38 MAP kinases on HeLa cell apoptosis induced by dipyrithione. Mol. Cells 23, 30-38.
14. Gerritsen, M. E. (1998) Inhibitors of cytokine induced gene expression. Adv. Exp. Med. Biol. 439, 183-190.
15. Gianinazzi, C., Grandgirard, D., Imboden, H., Egger, L., Meli, D. N., et al. (2003) Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis. Acta Neuropathol. 105, 499-507.
16. Green, D. R. and Reed, J. C. (1998) Mitochondria and apoptosis. Science 281, 1309-1312.
17. Grivicich, I., Regner, A., da Rocha, A. B., Grass, L. B., Alves, P. A., et al. (2005) Irinotecan/5-fluorouracil combination induces alterations in mitochondrial membrane potential and caspases on colon cancer cell lines. Oncol. Res. 15, 385-392.
18. Hsu, Y. L., Kuo, P. L., Liu, C. F., and Lin, C. C. (2004) Acacetin-induced cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells. Cancer Lett. 212, 53-60.
19. Hu, C. A., Tang, C. A., and Wang, J. (2001) Caspase activation in response to cytotoxic Rena catesbeiana ribonuclease in MCF-7 cells. FEBS Lett. 503, 65-68.
20. Jacobson, M. D. and Raff, M. C. (1995) Programmed cell death and Bcl-2 protection in very low oxygen. Nature 374, 814-816.
21. Jacobson, M. D., Burne, J. F., and Raff, M. C. (1994) Mechanisms of programmed cell death and Bcl-2 protection. Biochem. Soc. Trans. 22, 600-602.
22. Janicke, R. U., Sprengart, M. L., Wati, M. R., and Porter, A. G. (1998) Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 273, 9357-9360.
23. Jenal, A., Thomas, A., Murry, T., and Thun, M. (2002) Cancer stastics, 2002. CA Cancer J. Clin. 52, 23-37.
24. Johnson, G. L. and Lapadat, R. (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298, 1911-1912.
25. Johnston, S. R. (1997) Acquired tamoxifen resistance in human breast cancer-potential mechanisms and clinical implications. Anticancer Drugs 8, 911-930.
26. Kallio, A., Zheng, A., Dahllund, J., Heiskanen, K. M., and Harkonen, P. (2005) Role of mitochondria in tamoxifen-induced rapid death of MCF-7 breast cancer cells. Apoptosis 10, 1395-1410.
27. Kanno, S., Tomizawa, A., Ohtake, T., Koiwai, K., Ujibe, M., et al. (2006) Naringenin-induced apoptosis via activation of NF-kappaB and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cells. Toxicol Lett. 166, 131-139.
28. Kato, S., Endoh, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., et al. (1995) Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270, 1491-1494.
29. Kraft, C., Jenett-Siems, K., Siems, Y,, Jakupovic, J., Mavi, S., et al. (2003) In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe. Phytother. Res. 17, 123-128.
30. Lu, G., Liao, J., Yang, G., Reuhl, K. R., Hao, X., et al. (2006) Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine. Cancer Res. 66, 1494-1501.
31. Lupu, R., Cardillo, M., Cho, C., Harris, L., Hijazi, M., et al. (1996) The significance of heregulin in breast cancer tumor progression and drug resistance. Breast Cancer Res. Treat. 38, 57-66.
32. Matsura, T., Kai, M., Fujii, Y., Ito, H., and Yamada, K. (1999) Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation. Free Radic. Res. 30, 73-83.
33. Middleton, E., Kandaswami, C., and Theoharides, T. C. (2000) The effect of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 52, 673-751.
34. Minden, A. and Karin, M. (1997) Regulation and function of the JNK subgroup of MAP kinases. Biochim. Biophy. Acta 1333, F85-F105.
35. Mohammad, R. M., Banerjee, S., Li, Y., Aboukameel, A., Kucuk, O., et al. (2006) Cispain-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenografts. Cancer 106, 1260-1268.
36. Pan, M. H., Lai, C. S., Hsu, P. C., and Wang, Y. J. (2005) Acacetin induces apoptosis in human gastric carcinoma cells accompanied by activation of caspase cascades and production of reactive oxygen species. J. Agric. Food Chem. 53, 620-630.
37. Pan, M. H., Lai, C. S., Wang, Y, J., and Ho, C. T. (2006) Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. Biochem. Pharmacol. 72, 1293-303.
38. Plaumann, B., Fritsche, M., Rimpler, H., Brandner, G., and Hess, R. D. (1996) flavonoids activate wild-type p53. Oncogene 13, 1605-1614.
39. Raingeaud, J., Gupta, S., Rogers, J. S., Dicken, M., Han, J., et al. (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270, 7420-7426.
40. Rao, L. and White, E. (1997) Bcl-2 and the ICE family of apoptotic regulators: making connection. Curr. Opin. Genet. Dev. 7, 52-58.
41. Schrivastava, A., Tiwari, M., Sinha, R. A., Kumar, A., Balapure, A. K., et al. (2006) Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving mitochondria-mediated pathway. J. Biol. Chem. 281, 19762-19771.
42. Singh, R. P., Agrawal, P., Yim, D., Agarwal, C., and Agarwal, R. (2005) Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. Carcinogenesis 26, 845-54.
43. Smith, L. L., Brown, K., Carthew, P., Lim, C. K., Martin, E. A., et al. (2000) Chemoprevention of breast cancer by tamoxifen: risks and opportunities. Crit. Rev. Toxicol. 30, 571-594.
44. Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., et al. (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397, 441-446.
45. Tsujimoto, Y. (1998) Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitichondria? Genes Cells 3, 697-707
46. Twiddy, D., Cohen, G. M., MacFarlane, M., and Cain, K. (2006) Caspase, 7 is directly activated by the ∼700 kDa apoptosome complex and is released as a stable XIAP-caspase 7-200 kDa complex. J. Biol. Chem. 281, 3876-3888.
47. Yim, S. H., Kim, H. J., and Lee, I. S. (2003) A polyacetylene and flavonoids from Cirsium rhinoceros. Arch. Pharm. Res. 26, 128-131.
48. Zhang, K., Yang, E. B., Tang, W. Y., Wong, K. P., and Mack, P. (1997) Inhibition of glutathione reductase by plant polyphenols. Biochem. Pharmacol. 54, 1047-1053.
49. Zheng, T. S., Schlosser, S. F., Dao, T., Hingorani, R., Crispe, I. N., et al. (1998) Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proc. Natl. Acad Sci. USA 95, 13618-13623.