The effects of thymol on sister chromatid exchange, chromosome aberration and micronucleus in human lymphocytes

Ecotoxicology and Environmental Safety

Volumn 72, Issue 3, 2009, Pages 943-947

  Buyukleyla, Mehmet ^a   Rencuzogullari, Eyyup ^a  

^a CUKUROVA UNIVERSITY   (Turkey)

Author keywords

Chromosome aberrations; Human peripheral lymphocytes; Micronucleus; Sister chromatid exchanges; Thymol

Indexed keywords

THYMOL;

BLOOD; CHROMOSOME; DOSE-RESPONSE RELATIONSHIP; GENOTOXICITY; HOMINID; PHENOL;

ADULT; ARTICLE; CELL DIVISION; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE; MALE; MICRONUCLEUS; MITOSIS INDEX; NUCLEAR DIVISION; SISTER CHROMATID EXCHANGE;

ADULT; CHROMOSOME ABERRATIONS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LYMPHOCYTES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MUTAGENICITY TESTS; MUTAGENS; SISTER CHROMATID EXCHANGE; THYMOL; YOUNG ADULT;

EID: 59149103608     PISSN: 01476513     EISSN: 10902414     Source Type: Journal    
DOI: 10.1016/j.ecoenv.2008.10.005     Document Type: Article

References (60)

1. Abraham S.K. Antigenotoxicity of trans-anethole and eugenol in mice. Food Chem. Toxicol. 39 (2001) 493-498
2. Aeschbach R., Loliger J., Scott B.C., Mucia A., Butler J., and Halliwell B. Antioxidant action of thymol, carvacrol, 6-ginerol, zinezerone and hydroxytyrosol. Food Chem. Toxicol. 32 (1994) 31-36
3. Al-Bataina B.A., Maslat A.O., and Al-Kofahil M.M. Element analysis and biological studies on ten oriental spices using XRF and Ames test. J. Trace. Elem. Med. Biol. 17 (2003) 85-90
4. Albertini R.J., Anderson D., Douglas G.R., Hagmar L., Hemminki K., Merlo F., Natarajan A.T., Norppa H., Shuker D.E.G., Tice R., Waters M.D., and Aitio A. IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. Mutat. Res. 463 (2000) 111-172
5. Armstrong M.J., Bean C.L., and Galloway S.M. A quantitative assessment of cytotoxicity associated with chromosomal aberration detection in Chinese hamster ovary cells. Mutat. Res. 265 (1992) 45-60
6. Aromatherapy Science. The Safety Issue in Aromatherapy (2006), Pharmaceutical Press. 0-85369-578-4 pp. 75-92
7. Aydin S., Basaran A.A., and Basaran N. The effects of thyme volatiles on the induction of DNA damage by the heterocyclic amine IQ and mitomycin C. Mutat. Res. 581 (2005) 43-53
8. Azirak S., and Rencuzogullari E. The in vivo genotoxic effects of carvacrol and thymol in rat bone marrow cells. Environ. Toxicol. (2008) 10.1002/tox.20380
9. Bakkali F., Averbeck S., Averbeck D., Zhiri A., and Idaomar M. Cytotoxicity and gene induction by some essential oils in the yeast Saccharomyces cerevisiae. Mutat. Res. 585 (2005) 1-13
10. Burkhard P.R., Burkhardt K., Haenqqeli C.A., and Landis T. Plant-induced seizures, reappearance of an old problem. J. Neurol. 246 (1999) 667-670
11. Cheng C.H.K., Costall B., Hamburger M., Hostettmann K., Naylor R.J., Wang Y., and Jenner P. Toxic effects of solstitialin A 13-acetate and cyanoropicrin from Centaurea solstitialis L. (Asteraceae) in cell cultures of foetal rat brain. Neurupharmacology 31 (1992) 271-277
12. Chiang T.A., Wu P.F., Wang L.F., Lee H., Lee C.H., and Ko Y.C. Mutagenicity and polycylic aromatic hydrocarbon content of fumes from heated cooking oils produced in Taiwan. Mutat. Res. 381 (1997) 157-161
13. El-Ashmawy I.M., El-Nahas A.F., and Salama O.M. Protective effects of volatile oil, alcoholic and aqueous extracts of Origanum majorana on lead acetate toxicity in mice. Basic Clin. Pharmacol. Toxicol. 97 (2005) 238
14. Epel D. The effects of carbon monoxide inhibition of ATP level and the date of mitosis in Sea Urchin egg. J. Cell Biol. 17 (1963) 315-319
15. Evans H.J. Human peripheral blood lymphocytes fort he analysis of chromosome aberrations in mutagen tests. In: Kilbey B.J., Legator M., Nichols W., and Ramel C. (Eds). Handbook of Mutagenicity Test Procedures. second ed. (1984), Elsevier Sciences Publishers, Amsterdam 405-427
16. Fenech M. The in vitro micronucleus technique. Mutat. Res. 455 (2000) 81-95
17. Francis A.A., Snyder R.D., Dunn W.C., and Regan J.D. Classification of chemical agents as to their abiltiy to induce long- or short-patch DNA repair in human cells. Mutat. Res. 83 (1981) 159-169
18. Franzios G., Mirotsou M., Hatziapostolou E., Kral J., Scouras Z.G., and Mavragani P.T. Insecticidal and genotoxic activities of mint essential oils. J. Agric. Food. Chem. 45 (1997) 2690-2694
19. Gadano A.B., Gurni A.A., and Carballo M.A. Argentine folk medicine, genotoxic effects of Chenopodiaceae family. J. Ethnopharmacol. 103 (2006) 246-251
20. Galloway S.M., Miller J.E., Armstrong M.J., Bean C.L., Skopek T.R., and Nichols W.W. DNA synthesis inhibition as an indirect mechanism of chromosome aberrations, comparison of DNA-reactive and non-DNA-reactive clastogens. Mutat. Res. 400 (1998) 169-186
21. Gaworski C.L., Dozier M.M., Gerhart J.M., Rajendrans N., Brennecke L.H., Aranyi C., and Heck J.D. 13-Week inhalation toxicity study of menthol cigarette smoke. Food Chem. Toxicol. 35 (1997) 683-692
22. Gomes-Carneiro R., Felzenszwalb I., and Paumgartten F.J. Mutagenicity testing (+) -camphor, 1,8 cineole, citral, citronellol, (-)-menthol and terpineol with the Salmonella microsome assay. Mutat. Res. 416 (1998) 129-136
23. Higashimoto M., Yamato H., Kinouchi T., and Ohnishi Y. Inhibitory effects of citrus fruits on the mutagenicity of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid treated with nitrite in the presence of ethanol. Mutat. Res. 415 (1998) 219-226
24. Hillard C.A., Armstrong M.J., Bradt C.I., Hill R.B., Greenwood S.K., and Galloway S.M. Chromosome aberrations in vitro related to cytotoxicity of non-mutagenic chemicals and metabolic poisons. Environ. Mol. Mutagen. 31 (1998) 316-326
25. Horvathova E., Sramkova M., Labaj J., and Slamenova D. Study of cytotoxic, genotoxic and DNA-protective effects of selected plant essential oils on human cells cultured in vitro. Neuro. Endocrinol. Lett. 2 (2006) 44-47
26. Horvathova E., Turcaniova V., and Slamenova D. Comparative study of DNA-damaging and DNA-protective effects of selected components of essential plant oils in human leukemic cells K562. Neoplasma 54 (2007) 478-483
27. Huma F., Jaffar M., and Masud K. A Modified potentiometric method for the estimation of phenol in aqueous systems. Turk. J. Chem. 23 (1999) 415-422
28. Ipek E., Tuylu B.A., and Zeytinoglu H. Effects of carvacrol on sister chromatid exchanges in human lymphocyte cultures. Cytotechnology 43 (2003) 145-148
29. Ipek E., Zeytinoglu H., Okay S., Tuylu B.A., Kurkcuoglu M., and Baser K.H.C. Genotoxicity and antigenotoxicity of Origanum oil and carvacrol evaluated by Ames Salmonella/microsomal test. Food Chem. 93 (2005) 551-556
30. Jain A.K., and Andsorbhoy R.K. Cytogenetical studies on the effects of some chlorinated pesticides III. Concluding remarks. Cytologia 53 (1988) 427-436
31. Karpouhtsis I., Pardali E., Feggou E., Kokkini S., Scouras Z.G., and Mavragani-Tsipidou P. Insectisidal and genotoxic activities of Oregano essential oils. J. Agric. Food. Chem. 46 (1998) 1111-1115
32. Kim D.H., Lee S.K., Chun B.G., Lee D.H., Hong S.C., Jang B.K., and Korean J. Illness associated with contamination of drinking water supplies with phenol. J. Korean Med. Sci. 9 (1994) 218-223
33. Kirkland D.J., and Müller L. Interpretation of the biological relevance of genotoxicity test results, the importance of thresholds. Mutat. Res. 464 (2000) 137-147
34. Kirsch-Volders M., Sofuni T., Aardemac M., Albertini S., Eastmond D., Fenech M., Ishidate J.M., Kirchner S., Lorge E., Morita T., Norppa H., Surrallés J., Vanhauwaert A., and Wakata A. Report from the in vitro micronucleus assay working group. Mutat. Res. 540 (2003) 153-163
35. Kuo M.L., Lee K.C., and Lin J.K. Genotoxicity of nitropyrenes and their modulation by apigenin, tannic acid, ellagic acid and indole-3-carbinol in the Salmonella and CHO systems. Mutat. Res. 270 (1992) 87-95
36. Lazutka J.R., Mierauskien J., Slapsyte G., and Dedonyte V. Genotoxicity of dill (Anethum graveolens L.), peppermint (Mentha piperita L.) and pine (Pinus sylvestris L.) essential oils in human lymphocytes and Drosophila melanogaster. Food Chem. Toxicol. 39 (2001) 485-492
37. Mace M.L.J., Daskal Y., and Wray W. Scanning electron microscopy of chromosome aberrations. Mutat. Res. 52 (1978) 199-206
38. Madle S., Beek B., and Nowak C. Zum Verständnis von Chromosomenmutationstests an Somazellen. In: Fahrig R. (Ed). Mutationsforschung und Genetische Toxicologie (1993), Wissenschaftliche Buchgesellschaft Publishers 224-242
39. Manou I.L., Bouillard M., Devleeschouwer J., and Barel A.O. Evaluation of the preservation properties of Thymus vulgaris essential oil in applied formulations under a challenge test. J. Appl. Microbiol. 84 (1998) 368-376
40. Maura A., Pino A., and Ricci R. Negative evidence in vivo of DNA-damaging, mutagenic and chromosomal effects of eugenol. Mutat. Res. 227 (1989) 125-129
41. Millet Y., Jouglard J., Steinmetz M.D., Tognetti P., Joanny P., and Arditti J. Toxicity of some essential plant oils: clinical and experimental study. Clin. Toxicol. 18 (1981) 1485-1498
42. National Toxicology Program, 1982. CHO cell cytogenetics: chromosome aberrations and sister chromatid exchanges from exposure to 1,8 cineole. Study 590755.
43. OPSW, 1994. Oxidation of Phenolics in Supercritical Water. Quarterly Technical Progress Report, 1 Dec. 1993-28 Feb. 1994, Gov. Reports, Announcements and Index (GRA & I), Issue 21, 422pp.
44. Paz-y-Miño C., Bustamante G., Sánchez M.E., and Leone P.E. Cytogenetic monitoring in a population occupationally exposed to pesticides in Ecuador. Environ. Health Perspect. 110 (2002) 1077-1080
45. Perry P.E., and Thompson E.J. The methodology of sister chromatid exchanges. In: Kilbey B.J., Legator M., Nichols W., and Ramel C. (Eds). Handbook of Mutagenicity Test Procedures. second ed. (1984), Elsevier Sciences Publishers, Amsterdam 495-529
46. Phillips D.H., Miller J.A., Miller E.C., and Adams B. Structures of the DNA adducts formed in mouse liver after administration of the proximate hepatocarcinogen 1′-hydroxyestragole. Cancer Res. 41 (1981) 176-186
47. Qu Y.H., Xu G.X., Zhou J.Z., Chen T.D., Zhu L.F., Shields P.G., Wang H.W., and Gao Y.T. Genotoxicity of heated cooking oil vapors. Mutat. Res. 298 (1992) 105-111
48. Ramos A., Visozo A., Piloto J., Garcia A., Rodriguez C.A., and Rivero R. Screening of antimutagenicity via antioxidant activity in Cuban medicinal plants. J. Ethnopharmacol. 87 (2003) 241-246
49. Robles C., Bonin G., and Garzino Z. Autotoxic and allelopathic potentials of Cistus albidus L. C. R. Acad. Sci. III 322 (1999) 677-685
50. Ruch R.J., and Sigler K. Growth inhibition of rat liver epithelial tumor cells by monoterpenes does not involve rat plasma membrane association. Carcinogenesis 15 (1994) 787-789
51. Sekizawa J., and Shibamoto T. Genotoxicity of safrole-related chemicals in microbial test systems. Mutat. Res. 101 (1982) 127-140
52. Shapiro S., Meier A., and Guggenheim B. The antimicrobiol activity of essential oils and essential oil components toward oral bacteria. Oral Microbiol. Immunol. 9 (1994) 202-208
53. Shields P.G., Xu G.X., Blot W.J., Fraumeni Jr. J.F., Trivers G.E., Pellizzari E.D., Qu Y.H., Gao Y.T., and Haris C.C. Mutagens from heated Chinese and U.S. cooking oils. J. Natl. Cancer Inst. 87 (1995) 836-841
54. Speit G., and Haupter S. On the mechanism of differential giemsa staining of bromodeoxyuridine substituted chromosomes. II. differences between the demostration of sister chromatid differentiation and replication patterns. Hum. Gen. 70 (1985) 126-129
55. Stammati A., Bonsi P., Zucco F., Moezelaar R., Alakomi H.L., and Von Wright A. Toxicity of selected plant volatiles in microbial and mammalian short-term assays. Food Chem. Toxicol. 37 (1999) 813-823
56. Steinmetz M.D., Vial M., and Millet Y. Actions of essential oils of rosemary and certain its constituents (eucalyptol and camphor) on the cerebral cortex of the rat in vivo. J. Toxicol. Clin. Exp. 7 (1987) 259-271
57. Vock E.H., Lutz W.K., Hormes P., Hoffmann H.D., and Vamvakas S. Discrimination between genotoxicity and cytotoxicity in the induction of DNA double-strand breaks in cells treated with etoposide, melphalan, cisplatin, potassium cyanide, Triton X-100 and γ-irradiation. Mutat. Res. 413 (1998) 83-94
58. WHO, 1999. Phenol and Phenol Derivatives. WHO Food Additives Series no. 46.
59. Whysner J., and Williams G.M. d-Limonene mechanistic data and risk assessment: absolute species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion. Pharmacol. Therapeut. 71 (1996) 127-136
60. Young S., Brown W.W., and Klinger B. Nigropallidal encephalomalacia in horses fed Russian knapweed (Centaurea repens L.). Am. J. Vet. Res. 31 (1970) 139