Interpretation of the biological relevance of genotoxicity test results: The importance of thresholds

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 464, Issue 1, 2000, Pages 137-147

  Kirkland, David J ^a   Müller, Lutz ^b  

^a UK   (United Kingdom)

^b Bundesinstitut Arzneimittel M   (Germany)

Author keywords

Biological relevance; Genotoxicity; Mechanisms; Thresholds

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 1 DODECYLIMIDAZOLE; 2,4 DINITROPHENOL; 3 AMINOBENZAMIDE; 6 CHLORO 9 [3 (2 CHLOROETHYL)AMINOPROPYLAMINO] 2 METHOXYACRIDINE; AFLATOXIN B1; AMSACRINE; APHIDICOLIN; ASBESTOS; CAMPTOTHECIN; CHLOROPRENE; CHROMIUM CHLORIDE; CLASTOGEN; CYANIDE; CYCLOHEXIMIDE; CYTARABINE; DEOXYADENOSINE; DIETHYLDITHIOCARBAMIC ACID; ETOPOSIDE; FLOXURIDINE; FLUDARABINE; FLUORIDE; FORMALDEHYDE; HYDROGEN PEROXIDE; HYDROXYUREA; HYPOCHLORITE; IODOACETIC ACID; MALEIC ACID DIETHYL ESTER; MESYLIC ACID ETHYL ESTER; MESYLIC ACID METHYL ESTER; METHOTREXATE; METHYLNITRONITROSOGUANIDINE; METHYLNITROSOUREA; MITOMYCIN C; MUTAGENIC AGENT; N (2 FLUORENYL)ACETAMIDE; NITRILOTRIACETIC ACID; OUABAIN; PARAQUAT; PHORBOL 13 ACETATE 12 MYRISTATE; SODIUM AZIDE;

AMES TEST; CHROMOSOME ABERRATION; CONFERENCE PAPER; DATA ANALYSIS; DOSE RESPONSE; DRUG SCREENING; GENE MUTATION; GENOTOXICITY; HUMAN; IN VITRO STUDY; INTERMETHOD COMPARISON; LYMPHOMA CELL LINE; MAXIMUM ALLOWABLE CONCENTRATION; METABOLIC ACTIVATION; MICRONUCLEUS TEST; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUIDELINES; HUMANS; MUTAGENICITY TESTS; MUTAGENS; TOXICOLOGY;

RODENTIA;

EID: 0342288641     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(99)00175-8     Document Type: Conference Paper

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