DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: Comparison of DNA-reactive and non-DNA-reactive clastogens

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 400, Issue 1-2, 1998, Pages 169-186

  Galloway, Sheila M ^a   Miller, Judith E ^a   Armstrong, Michael J ^a   Bean, Christian L ^a   Skopek, Thomas R ^a   Nichols, Warren W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Genotoxicity associated with cytotoxicity

Indexed keywords

2,4 DICHLOROPHENOL; 4 NITROQUINOLINE 1 OXIDE; 4,4' ISOPROPYLIDENEDIPHENOL; ALKYLATING AGENT; APHIDICOLIN; BROXURIDINE; CLASTOGEN; DIETHYLDITHIOCARBAMIC ACID; DIMETHYL SULFOXIDE; DNA; EPHEDRINE; ETHYLNITROSOUREA; ETOPOSIDE; IODOACETIC ACID; MENTHOL; MESYLIC ACID ETHYL ESTER; MESYLIC ACID METHYL ESTER; METHYLNITROSOUREA; MITOMYCIN C; PHENFORMIN; PHENYLEPHRINE; TACRINE;

ANIMAL CELL; ARTICLE; CHO CELL; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA STRAND BREAKAGE; DNA SYNTHESIS INHIBITION; FLOW CYTOMETRY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APHIDICOLIN; BROMODEOXYURIDINE; CELL COUNT; CELL CYCLE; CHO CELLS; CHROMOSOME ABERRATIONS; CRICETINAE; DNA; DNA TOPOISOMERASES, TYPE I; ETOPOSIDE; FLOW CYTOMETRY; MUTAGENICITY TESTS; MUTAGENS; NUCLEIC ACID SYNTHESIS INHIBITORS;

EID: 0032565516     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(98)00044-X     Document Type: Article

References (20)

1. [1] B.A. Kihlman, W.W. Nichols, A. Levan, The effect of deoxyadenosine and cytosine arabinoside on the chromosomes of human leukocytes in vitro, Hereditas 50 (1963) 139-143.
2. [2] W.W. Nichols, In vitro chromosome breakage induced by arabinosyladenine in human leukocytes, Cancer Res. 24 (8) (1964) 1502-1505.
3. [3] T.S.-F. Wang, Eukaryotic DNA polymerases, Annu. Rev. Biochem. 60 (1991) 513-552.
4. [4] A.A. van Zeeland, C.J.M. Bussmann, F. Degrassi, A.R. Filon, A.C. van Kesteren-van Leeuwen, F. Palitti, A.T. Natarajan, Effects of aphidicolin on repair replication and induced chromosomal aberrations in mammalian cells, Mutation Res. 92 (1982) 379-392.
5. [5] J.R. Selden, J.E. Miller, F. Dolbeare, S.M. Galloway, W.W. Nichols, Cytokinetic studies reveal etiology of cytogenotoxic genotoxicity produced by a series of angiotensin II (AII) receptor antagonists may be perturbed DNA synthesis, Cytometry Suppl. 6 (1993) 64.
6. [6] C.A. Milliard, M.J. Armstrong, C.I. Bradt, R.B. Hill, S.K. Greenwood, S.M. Galloway, Chromosome aberrations in vitro related to cytotoxicity of non-mutagenic chemicals and metabolic poisons, Environ. Mol. Mutagen., 1998, in press.
7. [7] C.L. Bean, M.J. Armstrong, S.M. Galloway, Effect of sampling time on chromosome aberration yield for 7 chemicals in Chinese hamster ovary cells, Mutation Res. 265 (1992) 31-44.
8. [8] F. Dolbeare, W. Beisker, M.G. Pallavicini, M. Vanderlaan, J.W. Gray, Cytochemistry for bromodeoxyuridine/DNA analysis: stoichiometry and sensitivity, Cytometry 6 (1985) 521-530.
9. [9] F.L. Graham, G.F. Whitmore, Studies in mouse L cells on the incorporation of 1-β-D-arabinofuranosylcytosine with DNA and on inhibition of DNA polymerase by 1-β-D-arabinofuranosylcytosine 5′-triphosphate, Cancer Res. 30 (1970) 2636-2644.
10. [10] W.W. Au, D.A. Johnston, C. Collie-Bruyere, T.C. Hsu, Short-term cytogenetic assays of nine cancer chemotherapeutic drugs with metabolic activation, Environ. Mutagen. 2 (1980) 455-464.
11. [11] E. Zeiger, G. Erexson, K. Mortelmans, A. Thilagar, Genetic toxicity of 1,2,3,4-tetrahydro-9-acridinamine (tacrine), Mutation Res. 393 (1997) 189-197.
12. [12] R.B. Painter, R. Howard, The HeLa DNA-synthesis inhibition test as a rapid screen for mutagenic carcinogens, Mutation Res. 92 (1982) 427-437.
13. [13] M.C. Elia, R.D. Storer, L.S. Harmon, A.R. Kraynak, T.W. McKelvey, P.R. Hertzog, K.P. Keenan, J.G. DeLuca, W.W. Nichols, Cytotoxicity as measured by trypan blue as a potentially confounding variable in the in vitro alkaline elution/rat hepatocyte assay, Mutation Res. 291 (1993) 193-205.
14. [14] M.C. Elia, R.D. Storer, T.W. McKelvey, A.R. Kraynak, J.E. Barnum, L.S. Harmon, J.G. DeLuca, W.W. Nichols, Rapid DNA degradation in primary rat hepatocytes treated with diverse cytotoxic chemicals: analysis by pulsed field gel electrophoresis and implications for alkaline elution assays, Environ. Mol. Mutagen. 24 (1994) 181-191.
15. [15] R.D. Storer, T.W. KcKelvey, A.R. Kraynak, M.C. Elia, J.E. Barnum, L.S. Harmon, W.W. Nichols, J.G. DeLuca, Revalidation of the in vitro alkaline elution/rat hepatocyte assay for DNA damage: improved criteria for assessment of cytotoxicity and genotoxicity and results for 81 compounds, Mutation Res. 368 (1996) 59-101.
16. 32P-post-labeling and multifraction contact-transfer thin-layer chromatography, Fund. Appl. Toxicol. 23 (1994) 308-312.
17. [17] S.P. Adams, G.M. Laws, R.D. Storer, J.G. DeLuca, W.W. Nichols, Detection of DNA damage induced by human carcinogens in acellular assays: potential application for determining genotoxic mechanisms, Mutation Res. 368 (1996) 235-248.
18. [18] D.T. Beranek, Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents, Mutation Res. 231 (1990) 11-30.
19. [19] L.R. Ferguson, B.C. Baguley, Topoisomerase II enzymes and mutagenicity, Environ. Mol. Mutagen. 24 (1994) 245-261.
20. [20] R.B. Painter, Inhibition of initiation of HeLa cell replicons by methyl methanesulfonate, Mutation Res. 42 (1977) 299-304.