Allylnitrile metabolism by CYP2E1 and other CYPs leads to distinct lethal and vestibulotoxic effects in the mouse

Toxicological Sciences

Volumn 107, Issue 2, 2009, Pages 461-472

  Boadas Vaello, Pere ^a   Jover, Eric ^b   Saldaña Ruíz, Sandra ^a   Soler Martín, Carla ^a   Chabbert, Christian ^c   Bayona, Josep M ^b   Llorens, Jordi ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTE OF ENVIRONMENTAL ASSESSMENT AND WATER RESEARCH   (Spain)

^c Inst Natl de la Sante et de la R   (France)

Author keywords

Cyanide; CYP2A5; CYP2E1; Nitrile; Ototoxicity; Vestibular toxicity; Xenobiotic metabolism

Indexed keywords

1 AMINOBENZOTRIAZOLE; ALLYNITRILE; CYANIDE; CYTOCHROME P450 2A5; CYTOCHROME P450 2E1; DRUG METABOLIZING ENZYME; METHOXSALEN; NITRILE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYANIDE POISONING; DOSE RESPONSE; DRUG EXPOSURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME RELEASE; EPOXIDATION; HYDROXYLATION; LIVER MICROSOME; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; OTOTOXICITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCANNING ELECTRON MICROSCOPY; TOXICITY TESTING; XENOBIOTIC METABOLISM;

ACETONE; ALLYL COMPOUNDS; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BEHAVIOR, ANIMAL; CYANIDES; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EPOXY COMPOUNDS; INDICATORS AND REAGENTS; MICE; MICE, KNOCKOUT; NITRILES; SOLVENTS; VESTIBULAR DISEASES; VESTIBULAR FUNCTION TESTS; VESTIBULE, LABYRINTH;

ANIMALIA; MUS;

EID: 59149098059     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn233     Document Type: Article

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