Comparison of behavioral, vestibular, and axonal effects of subchronic IDPN in the rat

Neurotoxicology and Teratology

Volumn 19, Issue 2, 1997, Pages 117-127

  Llorens, Jordi ^a,b   Rodríguez Farré, Eduardo ^a  

^a INST D INVESTIGACIONS B   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

3,3' Iminodipropionitrile; Motor and sensory neurons; Neurofilaments; Nitriles; Proximal axonopathy; Vestibular hair cells

Indexed keywords

3,3' IMINODIPROPIONITRILE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; HISTOLOGY; MALE; MOTOR ACTIVITY; NEUROFILAMENT; NEUROPATHY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; VESTIBULAR DISORDER;

ADMINISTRATION, ORAL; ANIMALS; ARSANILIC ACID; AXONS; BEHAVIOR, ANIMAL; DRINKING; EAR, INNER; GANGLIA, SPINAL; HAIR CELLS, VESTIBULAR; MALE; MOTOR ACTIVITY; NEUROTOXINS; NITRILES; RATS; SPINAL CORD; VESTIBULAR DISEASES;

ANIMALIA;

EID: 0342460602     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0892-0362(96)00216-4     Document Type: Article

References (39)

1. Barone, S., Jr.; Herr, D. W.; Crofton, K. M.: Effects of 3,3′-iminodipropionitrile on the peripheral structures of the rat visual system. Neurotoxicology 16:451-468; 1995.
2. Chen, Y.-C.; Pellis, S. M.; Sirkin, D. W.; Potegal, M.; Teitelbaum, P.: Bandage backfall: Labyrinthine and non-labyrinthine components. Physiol. Behav. 37:805-814; 1986.
3. Chou, S. M.; Hartmann, H. A.: Axonal lesions and waltzing syndrome after IDPN administration in rats. With a concept -"Axostasis." Acta Neuropathol. (Berl.) 3:428-450; 1964.
4. Clark, A. W.; Griffin, J. W.; Price, D. L.: The axonal pathology in chronic IDPN intoxication. J. Neuropathol. Exp. Neurol. 39:42-55; 1980.
5. Croton, K. M.; Knight, T.: Auditory deficits and motor dysfunction following iminodipropionitrile administration in the rat. Neurotoxicol. Teratol. 13:575-581; 1991.
6. Crofton, K. M.; Janssen, R.; Prazma, J.; Pulver, S.; Barone, S. Jr.: The ototoxicity of 3,3′-iminodipropionitrile: Functional and morphological evidence of cochlear damage. Hear. Res. 80:129-140; 1994.
7. Dechesne, C. J.; Mbiene, J. P.; Sans, A.: Postnatal development of vestibular receptor surfaces in the rat. Acta Oto-laryngol. (Stockh.) 101:11-18; 1986.
8. Dechesne, C. J.; Scarfone, E.; Atger, P.; Desmadryl, G.: Neurofilament proteins form an annular superstructure in guinea-pig type I vestibular hair cells. J. Neurocytol. 23:631-640; 1994.
9. Delay, J.; Pichot, P.; Thuillier, J.; Marquiset, J. P.: Action de l'amino-dipropionitrile sur le comportement moteur de la souris blanche. C. R. Soc. Biol. 146:533-534; 1952.
10. Denlinger, R. H.; Anthony, D. C.; Amarnath, V.; Graham. D. G.: Comparison of location, severity, and dose response of proximal axonal lesions induced by 3,3′-iminodipropionitrile and deuterium substituted analogs. J. Neuropathol. Exp. Neurol. 51:569-576; 1992.
11. Elsner, J.; Looser, R.; Zbinden, G.: Quantitative analysis of rat behavior patterns in a residential maze. Neurobehav. Toxicol. 1(Suppl. 1):163-174; 1979.
12. Favre, D.; Sans, A.: Dedifferentiation phenomena after denervation of mammalian adult vestibular receptors. Neuroreport 2:501-504; 1991.
13. Genter, M. B.; Deamer, N. J.; Cao, Y.; Levi, P. E.: Effects of P450 inhibition and induction on the olfactory toxicity of β,β′-iminodipropionitrile (IDPN) in the rat. J. Biochem. Toxicol. 9:31-39; 1994.
14. Genter, M. B.; Llorens, J.; O'Callaghan, J. P.; Peele, D. B.; Morgan, K. T.; Crofton, K. M.: Olfactory toxicity of β,β′-iminodipropionitrile (IDPN) in the rat. J. Pharmacol. Exp. Ther. 263:1432-1439; 1992.
15. Gold, B. G.: The pathophysiology of proximal neurofilamentous giant axonal swellings: Implications for the pathogenesis of amyotrophic lateral sclerosis. Toxicology 46:125-139; 1987.
16. Goldey, E. S.; Kehn, L. S.; Croton, K. M.: The sensitivity to 3,3′-iminodipropionitrile differs for high-and midfrequency hearing loss in the developing rat. Hear. Res. 69:221-228; 1993.
17. Griffin, J. W.; Drucker, N.; Gold, B. G.; Rosenfeld, J.: Benzaquen, M.; Charnas, L. R.; Fahnestock, K. E.; Stocks, E. A.: Schwann cell proliferation and migration during paranodal demyelination. J. Neurosci. 7:682-699; 1987.
18. Griffin, J. W.; Hoffman, P. N.; Clark, A. W.; Carroll. P. T.; Price, D. L.: Slow axonal transport of neurofilament proteins: impairment by β,β′-iminidipropionitrile administration. Science 202:633-635; 1978.
19. Griffin, J. W.; Price, D. L.: Proximal axonopathies induced by toxic chemicals. In: Spencer, P. S.; Schaumburg, H. H., eds. Experimental and clinical neurotoxicology. Baltimore: Williams & Wilkins; 1980;161-178.
20. Griffin, J. W.; Price, D. L.: Demyelination in experimental β,β′-iminodipropionitrile and hexacarbon neuropathies. Lab. Invest. 45:130-141; 1981.
21. Heath, H.; Rutter, A. C.: Retinal angiopathy in the imino-dipropionitrile-treated alloxan-diabetic rat. Br. J. Exp. Pathol. 47:116-120; 1966.
22. Horn, K. M.; DeWitt, J. R.; Nielson, H. C.: Behavioral assessment of sodium arsanilate induced vestibular dysfunction in rats. Physiol. Psychol. 9:371-378; 1981.
23. Hunter-Duvar, I. M.; Hinojosa, R.: Vestibule: Sensory epithelia. In: Fiedmann, I.; Ballantyne, J., eds. Ultrastructural atlas of the inner ear. London: Butterworths; 1984:211-244.
24. Ivens, I.: Neurotoxicity during long-term studies. Neurotoxicol. Teratol. 12:637-641; 1990.
25. Komiya, Y.; Cooper, N. A.; Kidman, A. D.: The long-term effects of a single injection of β,β′-iminodipropionitrile on slow axonal transport in the rat. J. Biochem. 100:1241-1246; 1986.
26. Llorens, J.; Crofton, K. M.: Enhanced neurotoxicity of 3,3′-irninodipropionitrile following carbon tetrachloride pretreatment in the rat. Neurotoxicology 12:583-594; 1991.
27. Llorens, J.; Demêmes, D.: Hair cell degeneration resulting from 3,3′-iminodipropionitrile toxicity in the rat vestibular epithelia. Hear. Res. 76:78-86; 1994.
28. Llorens, J.; Demêmes, D.: 3,3′-Iminodipropionitrile induces neurofilament accumulations in the perikarya of rat vestibular ganglion neurons. Brain Res. 717:118-126; 1996.
29. Llorens, J.; Demêmes, D.; Sans, A.: The behavioral syndrome caused by 3,3′-iminodipropionitrile and related nitriles in the rat is associated with degeneration of the vestibular sensory hair cells. Toxicol. Appl. Pharmacol. 123:199-210; 1993.
30. Llorens, J.; Demêmes, D.; Sans, A.: The toxicity of IDPN on the vestibular system of the rat: New insights on its effects on behavior and neurofilament transport. Neurotoxicology 15:643-648; 1994.
31. Llorens, J.; Suñol, C.; Tusell, J. M.: Microcomputer adaptation of the wheel-shaped activity monitor: Effects of lindane. Pharmacol. Biochem. Behav. 35:1003-1006; 1990.
32. Mbiene, J.-P.; Sans, A.: Differentiation and maturation of the sensory hair bundles in the fetal and postnatal vestibular receptor of the mouse: A scanning electron microscopy study. J. Comp. Neurol. 254:271-278; 1986.
33. Moser, V. C.; Boyes, W. K.: Prolonged neurobehavioral and visual effects of short-term exposure to 3,3′-iminodipropionitrile (IDPN) in rats. Fundam. Appl. Toxicol. 21:277-290; 1993.
34. Peele, D. B.; Allison, S. D.; Crofton, K. M.: Learning and memory deficits in rats following exposure to 3,3′-iminodipropionitrile. Toxicol. Appl. Pharmacol. 105:321-332; 1990.
35. Sayre, L. M.; Autilio-Gambetti, L.; Gambetti, P.: Pathogenesis of experimental giant neurofilamentous axonopathies: A unified hypothesis based on chemical modification of neurofilaments. Brain Res. Rev. 10:69-83; 1985.
36. Schneider, G.; Oepen, H.; Klapproth, A.: The effect of the neurolathyrogenic substance β,β′-iminodipropionitrile (IDPN) on some biological parameters in rats and mice. Gen. Pharmacol. 12:109-114; 1981.
37. Selye, H.: Lathyrism. Rev. Can. Biol. 16:1-82; 1957.
38. Tanii, H.; Hayashi, M.; Hashimoto, K.: Nitrile-induced behavioral abnormalities in mice. Neurotoxicoiogy 10:157-166; 1989.
39. Tanii, H.; Kurosaka, Y.; Hayashi, M.; Hashimoto, K.: Allylnitrile: A compound which induces long-term dyskinesia in mice following a single administration. Exp. Neurol. 103:64-67; 1989.