Comparative metabolism of methacrylonitrile and acrylonitrile to cyanide using cytochrome P4502E1 and microsomal epoxide hydrolase-null mice

Toxicology and Applied Pharmacology

Volumn 205, Issue 2, 2005, Pages 116-125

  El Hadri, L ^a   Chanas, B ^a,b   Ghanayem, B I ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b Memory Pharmaceuticals Corporation   (United States)

Author keywords

Acrylonitrile; Cytochrome P4502E1; Methacrylonitrile

Indexed keywords

1 AMINOBENZOTRIAZOLE; ACRYLONITRILE; CYANIDE; CYTOCHROME P450 2E1; EPOXIDE HYDROLASE; METHACRYLONITRILE; NITRILE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPOXIDATION; FEMALE; GENOTYPE; GLUTATHIONE METABOLISM; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEX DIFFERENCE; TOXICITY; WESTERN BLOTTING; WILD TYPE;

ACRYLONITRILE; ANIMALS; BIOTRANSFORMATION; CYANIDES; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; EPOXIDE HYDROLASES; FEMALE; MALE; METHACRYLATES; MICE; MICE, KNOCKOUT; MICROSOMES, LIVER; MODELS, ANIMAL; NITRILES; SEX FACTORS;

ANIMALIA;

EID: 18944384752     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.10.002     Document Type: Article

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