Behavioral and pathological effects in the rat define two groups of neurotoxic nitriles

Toxicological Sciences

Volumn 88, Issue 2, 2005, Pages 456-466

  Boadas Vaello, Pere ^a   Riera, Judith ^a   Llorens, Jordi ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Allylnitrile; Crotononitrile; Hexadienenitrile; Iminodipropionitrile; Inferior olive; Motor behavior; Vestibular hair cells

Indexed keywords

NITRILE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL DEGENERATION; CHOREA; CONTROLLED STUDY; EXPOSURE; HAIR CELL; HYPERACTIVITY; MALE; MOTOR DYSFUNCTION; NERVE CELL DEGENERATION; NEUROTOXICITY; NONHUMAN; OLFACTORY BULB; OLFACTORY EPITHELIUM; PYRIFORM CORTEX; QUANTITATIVE ANALYSIS; RAT; SCORING SYSTEM; SPINAL CORD; VESTIBULAR DISORDER;

ANIMALS; BEHAVIOR, ANIMAL; FLUORESCENT DYES; HAIR CELLS, VESTIBULAR; MALE; NEURONS, AFFERENT; NEUROTOXINS; NITRILES; OLFACTORY BULB; OLIVARY NUCLEUS; ORGANIC CHEMICALS; RATS; RATS, LONG-EVANS; VESTIBULAR FUNCTION TESTS;

ANIMALIA;

EID: 27944445016     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfi314     Document Type: Article

References (40)

1. Balbuena, E., and Llorens, J. (2001). Behavioural disturbances and sensory pathology following allylnitrile exposure in rats. Brain Res. 904, 298-306.
2. Balbuena, E., and Llorens, J. (2003). Comparison of cis- and trans-crotononitrile effects in the rat reveals specificity in the neurotoxic properties of nitrile isomers. Toxicol. Appl. Pharmacol. 187, 89-100.
3. Barone, S., Jr., Herr, D. W., and Crofton, K. M. (1995). Effects of 3,3′-iminodipropionitrile on the peripheral structures of the rat visual system. Neurotoxicology 16, 451-468.
4. Cadet, J. L. (1989). The iminodipropionitrile (IDPN)-induced dyskinetic syndrome: Behavioral and biochemical pharmacology. Neurosci. Biobehav. Rev. 13, 39-45.
5. Chou, S. M., and Hartmann, H. A. (1964). Axonal lesions and waltzing syndrome after IDPN administration in rats. With a concept - "Axostasis." Acta Neuropathol. 3, 428-450.
6. Clark, A. W., Griffin, J. W., and Price, D. L. (1980). The axonal pathology in chronic IDPN intoxication. J. Neuropathol. Exp. Neurol. 39, 42-55.
7. Crofton, K. M., and Knight, T. (1991). Auditory deficits and motor dysfunction following iminodipropionitrile administration in the rat. Neurotoxicol. Teratol. 13, 575-581.
8. Crofton, K. M., Janssen, R., Prazma, J., Pulver, S., and Barone, S., Jr. (1994). The ototoxicity of 3,3′-iminodipropionitrile: Functional and morphological evidence of cochlear damage. Hear. Res. 80, 129-140.
9. Delay, J., Pichot, P., Thuillier, J., and Marquiset, J. P. (1952). Action de l'amino-dipropionitrile sur le comportement moteur de la souris blanche. C. R. Soc. Biol. 146, 533-534.
10. DeVito, S. C. (1996). Designing safer nitriles. In: Designing Safer Chemicals (S. C. DeVito, and R. L. Garrett, Eds.), pp. 194-223. American Chemical Society, Washingto, DC.
11. Fritschi, J. A., Lauterburg, T., and Burgunder, J. M. (2003). Expression of neurotransmitter genes in motor regions of the dyskinetic rat after iminodipropionitrile. Neurosci. Lett. 347, 45-48.
12. Genter, M. B., Llorens, J., O'Callaghan, J. P., Peele, D. B., Morgan, K. T., and Crofton, K. M. (1992). Olfactory toxicity of β,β′-iminodipropionitrile (IDPN) in the rat. J. Pharmacol. Exp. Ther. 263, 1432-1439.
13. Genter, M. B., Deamer, N. J., Cao, Y., and Levi, P. E. (1994). Effects of P450 inhibition and induction on the olfactory toxicity of beta,beta′-iminodipropionitrile (IDPN) in the rat. J. Biochem. Toxicol. 9, 31-39.
14. Genter, M. B., Owens, D. M., Carlone, H. B., and Crofton, K. M. (1996). Characterization of olfactory deficits in the rat following administration of 2,6-dichlorobenzonitrile (dichlobenil), 3,3′-iminodipropionitrile, or methimazole. Fundam. Appl. Toxicol. 29, 71-77.
15. Herr, D. W., King, D., Barone, S., Jr., and Crofton, K. M. (1995). Alterations in flash evoked potentials (FEPs) in rats produced by 3,3′-iminodipropionitrile (IDPN). Neurotoxicol. Teratol. 17, 645-656.
16. Hunt, M. A., Miller, S. W., Nielson, H. C., and Horn, K. M. (1987). Intratympanic injections of sodium arsanilate (atoxil) solution results in postural changes consistent with changes described for labyrinthectomized rats. Behav. Neurosci. 101, 427-428.
17. Llorens, J., Aguiló, A., and Rodríguez-Farré, E. (1998). Behavioral disturbances and vestibular pathology following crotonitrile exposure in rats. J. Periph. Nerv. Sys. 3, 189-196.
18. Llorens, J., Crofton, K. M., and O'Callaghan, J. P. (1993a). Administration of 3,3′-iminodipropionitrile to the rat results in region-dependent damage to the central nervous system at levels above the brain stem. J. Pharmacol. Exp. Ther. 265, 1492-1498.
19. Llorens, J., Demêmes, D., and Sans, A. (1993b). The behavioral syndrome caused by 3,3′-iminodipropionitrile and related nitriles in the rat is associated with degeneration of the vestibular sensory hair cells. Toxicol. Appl. Pharmacol. 123, 199-210.
20. Llorens, J., and Rodríguez-Farré, E. (1997). Comparison of behavioral, vestibular, and axonal effects of subchronic IDPN in the rat. Neurotoxicol. Teratol. 19, 117-127.
21. Nomoto, N. (2004). Inhibitory effect of free radical scavenger, MCI-186, in the increase of hydroxyl radical induced by iminodipropionitrile in rats. J. Neurol. Sci. 219, 41-44.
22. O'Donoghue, J. L. (2000). 2,4-Hexadiene-1-nitrile. In Experimental and Clinical Neurotoxicology (P. S. Spencer, H. H. Schaumburg, and A. C. Ludolph, Eds.), 2nd edition, p. 632. Oxford University Press, New York.
23. Ossenkopp, K.-P., Prkacin, A., and Hargreaves, E. L. (1990). Sodium arsanilate-induced vestibular dysfunction in rats: Effects on open-field behavior and spontaneous activity in the automated digiscan monitoring system. Pharmacol. Biochem. Behav. 36, 875-881.
24. Parker, A. J., and Clarke, K. A. (1990). Gait topography in rat locomotion. Physiol. Behav. 48, 41-47.
25. Paxinos, G., Kus, L., Ashwell, K. W. S., and Watson, C. (1999a). Chemoarchitectonic Atlas of the Rat Forebrain. Academic Press, San Diego, CA.
26. Paxinos, G., Carrive, P., Wang, H., and Wang, P.-Y. (1999b). Chemoarchitectonic Atlas of the Rat Brainstem. Academic Press, San Diego, CA.
27. Poirier, J. L., Capek, R., and De Koninck, Y. (2000). Differential progression of dark neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus. Neuroscience 97, 59-68.
28. Schmued, L. C., and Hopkins, K. J. (2000a). Fluoro-Jade B: A high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 874, 123-130.
29. Schmued, L. C., and Hopkins, K. J. (2000b). Fluoro-Jade: Novel fluorochromes for detecting toxicant-induced neuronal degeneration. Toxicol. Pathol. 28, 91-99.
30. Selye, H. (1957). Lathyrism. Rev. Canad. Biol. 16, 1-82.
31. Seoane, A., Apps, R., Balbuena, E., Herrero, L., and Llorens, J. (2005). Differential effects of trans-crotononitrile and 3-acetylpyridine on inferior olive integrity and behavioural performance in the rat. Eur. J. Neurosci. 22, 880-894.
32. Seoane, A., Dememes, D., and Llorens, J. (2001). Relationship between insult intensity and mode of hair cell loss in the vestibular system of rats exposed to 3,3′-iminodipropionitrile. J. Comp. Neurol. 439, 385-399.
33. Seoane, A., Espejo, M., Pallàs, M., Rodríguez-Farré, E., Ambrosio, S., and Llorens, J. (1999). Degeneration and gliosis in rat retina and central nervous system following 3,3′-iminodipropionitrile exposure. Brain Res. 833, 258-271.
34. Shoham, S., Chen, Y.-C., Devietti, T. L., and Teitelbaum. (1989). Deafferentation of the vestibular organ: Effects on atropine-resistant EEG in rats. Psychobiology 17, 307-314.
35. Slagel, D. E., and Hartmann, H. A. (1965). The distribution of neuroaxonal lesions in mice injected with iminodipropionitrile with special reference to the vestibular system. J. Neuropathol. Exp. Neurol. 24, 599-620.
36. Tanii, H., Zang, X.-P., Saito, N., and Saijoh, K. (2000). Involvement of GABA neurons in allylnitrile-induced dyskinesia. Brain Res. 887, 454-459.
37. Tanii, H., Hayashi, M., and Hashimoto, K. (1989a). Nitrile-induced behavioral abnormalities in mice. Neurotoxicology 10, 157-166.
38. Tanii, H., Kurosaka, Y., Hayashi, M., and Hashimoto, K. (1989b). Allylnitrile: A compound which induces long-term dyskinesia in mice following a single administration. Exp. Neurol. 103, 64-67.
39. Wakata, N., Araki, Y., Sugimoto, H., Iguchi, H., and Kinoshita, M. (2000). IDPN-induced monoamine and hydroxyl radical changes in the rat brain. Neurochem. Res. 25, 401-404.
40. Zang, X. P., Tanii, H., Kobayashi, K., Higashi, T., Oka, R., Koshino, Y., and Saijoh, K. (1999). Behavioral abnormalities and apoptotic changes in neurons in mice brain following a single administration of allylnitrile. Arch. Toxicol. 73, 22-32.