3,3′-Iminodipropionitrile induces neurofilament accumulations in the perikarya of rat vestibular ganglion neurons

Brain Research

Volumn 717, Issue 1-2, 1996, Pages 118-126

  Llorens, Jordi ^a   Demêmes, Danielle ^b  

^a INST D INVESTIGACIONS B   (Spain)

^b UNIV MONTPELLIER   (France)

Author keywords

3,3 Iminodipropionitrile; Axonal transport; Dorsal root ganglia; Myelinated perikarya; Neurofilament; Neurotoxicity; Proximal axonopathy; Vestibular ganglia

Indexed keywords

3,3' IMINODIPROPIONITRILE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL BODY; CELL SWELLING; CONTROLLED STUDY; IMMUNOCYTOCHEMISTRY; MALE; NERVE FIBER TRANSPORT; NEUROPATHY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL GANGLION; ULTRASTRUCTURE; VESTIBULAR SYSTEM;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; NEUROFILAMENT PROTEINS; NEURONS; NEUROTOXINS; NITRILES; RATS; RATS, INBRED STRAINS; TIME FACTORS; VESTIBULAR NUCLEI;

EID: 0029901596     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00034-0     Document Type: Article

References (38)

1. Carden, M.J., Goldstein, M.E., Bruce, J., Cooper, H.S. and Schlaepfer, W.W., Studies of neurofilaments that accumulate in proximal axons of rats intoxicated with β,β′-iminodipropionitrile, Neurochem. Pathol., 7 (1987) 189-205.
2. Chou, S.M. and Hartmann, H.A., Axonal lesions and waltzing syndrome after IDPN administration in rats. With a concept -'Axostasis', Acta Neuropathol., 3 (1964) 428-450.
3. Clark, A.W., Griffin, J.W. and Price, D.L., The axonal pathology in chronic IDPN intoxication, J. Neuropathol. Exp. Neurol., 39 (1980) 42-55.
4. Côté, F., Collard, J.-F. and Julien, J.-P., Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis, Cell, 73 (1993) 35-46.
5. Delay, J., Pichot, P., Thuillier, J. and Marquiset, J.-P., Action de l'amino-dipropionitrile sur le comportement moteur de la souris blanche, C. R. Soc. Biol., 146 (1952) 533-534.
6. Demêmes, D., Raymond, J., Atger, P., Grill, C., Winsky, L. and Dechesne, C.J., Identification of neuron subpopulations in the rat vestibular ganglion by calbindin-D 28K, calretinin and neurofilament proteins immunoreactivity, Brain Res., 582 (1992) 168-172.
7. Demêmes, D., Wenthold, R.J., Moniot, B. and Sans, A., Glutamate-like immunoreactivity in the peripheral vestibular system of mammals, Hear. Res., 46 (1990) 261-270.
8. Denlinger, R.H., Anthony, D.C., Amarnath, V. and Graham, D.G., Comparison of location, severity, and dose response of proximal axonal lesions induced by 3,3′-iminodipropionitrile and deuterium substituted analogs, J. Neuropathol. Exp. Neurol., 51 (1992) 569-576.
9. deWaegh, S.M., Lee, V.M.-Y. and Brady, S.T., Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells, Cell, 68 (1992) 451-463.
10. Dupont, J., Guilhaume, A. and Aran, J.-M., Neuronal degeneration of primary cochlear and vestibular innervations after local injection of sisomicin in the guinea pig, Hear. Res., 68 (1993) 217-228.
11. Ferri, G.-L., Cichi, A., Bastone, A., Gaudio, R.M., Frontali, N. and Dahl, D., Experimental β,β′-iminodipropionitrile (IDPN) neuropathy: neurofilament profile of sensory, motor and autonomie nerves as seen by immunocytochemistry on whole-mount preparations, Brain Res., 657 (1994) 315-319.
12. Figlewicz, D.A., Krizus, A., Martinoli, M.G., Meininger, V., Dib, M., Rouleau, G.A. and Julien, J.-P., Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis, Hum. Mol. Genet., 3 (1994) 1757-1761.
13. Gilbert, M.R., Harding, B.L., Hoffman, P.N., Griffin, J.W., Price, D.L. and Troncoso, J.C., Aluminum-induced neurofilamentous changes in cultured rat dorsal root ganglia explants, J. Neurosci., 12 (1992) 1763-1771.
14. Gold, B.G., The pathophysiology of proximal neurofilamentous giant axonal swellings: implications for the pathogenesis of amyotrophic lateral sclerosis, Toxicology, 46 (1987) 125-139.
15. Gold, B.G. and Austin, D.R, Regulation of aberrant neurofilament phosphorylation in neuronal perikarya. III. Alterations following single and continuous β,β′-iminodipropionitrile administrations, Brain Res., 563 (1991) 151-162.
16. Goldstein, M.E., Cooper, H.S., Bruce, J., Carden, M.J., Lee, V.M.-Y. and Schlaepfer W.W., Phosphorylation of neurofilament proteins and chromatolysis following transection of rat sciatic nerve. J. Neurosci., 7 (1987) 1586-1594.
17. Griffin, J.W., Fahnestock, K.E., Price, D.L. and Cork, L.C., Cytoskeletal disorganization induced by local application of β,β′-iminodipropionitrile and 2.5-hexanedione, Ann. Neurol., 14 (1983) 55-61.
18. Griffin, J.W., Hoffman, P.N., Clark, A.W., Carrol, P.T. and Price, D.L., Slow axonal transport of neurofilament proteins: impairment by β,β′-iminodipropionitrile administration, Science, 202 (1978) 633-635.
19. Griffin, J.W. and Price, D.L., Demyelination in experimental β,β′-iminodipropionitrile and hexacarbon neuropathies, Lab. Invest., 45 (1981) 130-141.
20. Hafidi, A. and Romand, R., Neurofilament immunoreactivity in vestibular ganglion neurons of the adult rat, Hear. Res., 42 (1989) 203-209.
21. Hsieh, S.T., Kidd, G.J., Crawford, T.O., Xu, Z.S., Lin, W.M., Trapp, B.D., Cleveland, D.W. and Griffin, J.W., Regional modulation of neurofilament organization by myelination in normal axons, J. Neurosci., 14 (1994) 6392-6401.
22. Komiya, Y., Cooper, N.A. and Kidman, A.D., The long-term effects of a single injection of β,β′-iminodipropionitrile on slow-axonal transport in the rat, J. Biochem., 100 (1986) 1241-1246.
23. Lasek, R.J., Paggi, P. and Katz, M.J., Slow axonal transport mechanisms move neurofilaments relentlessly in mouse optic axons, J. Cell Biol., 117 (1992) 607-616.
24. Lee, M.K. and Cleveland, D.W., Neurofilament function and dysfunction: involvement in axonal growth and neuronal disease, Curr. Opin. Cell Biol., 6 (1994) 34-40.
25. Lee, M.K., Marszalek, J.R. and Cleveland, D.W., A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron, 13 (1994) 975-988.
26. Llorens, J. and Demêmes, D., Hair cell degeneration resulting from 3,3′-iminodipropionitrile toxicity in the rat vestibular epithelia, Hear. Res., 76 (1994) 78-86.
27. Llorens, J., Demêmes, D. and Sans, A., The behavioral syndrome caused by 3,3′-iminodipropionitrile and related nitriles in the rat is associated with degeneration of the vestibular sensory hair cells, Toxicol. Appl. Pharmacol., 123 (1993) 199-210.
28. Llorens, J., Demêmes, D. and Sans, A., The toxicity of IDPN on the vestibular system of the rat: new insights on its effects on behavior and neurofilament transport, Neurotoxicology, 15 (1994) 643-648.
29. Mata, M., Kupina, N. and Fink, D.J., Phosphorylation-dependent neurofilament epitopes are reduced at the node of Ranvier, J. Neurocytol., 21 (1992) 199-210.
30. Muma, N.A. and Hoffman, P.N., Neurofilaments are intrinsic determinants of axonal caliber, Micron, 24 (1993) 677-683.
31. Nixon, R.A., Slow axonal transport, Curr. Opin. Cell Biol., 4 (1992) 8-14.
32. Nixon, R.A., The regulation of neurofilament protein dynamics by phosphorylation: clues to neurofibrillary pathobiology. Brain Pathol., 3 (1993) 29-38.
33. Perry, M.J., Lawson, S.N. and Robertson, J., Neurofilament immunoreactivity in populations of rat primary afferent neurons: a quantitative study of phosphorylatcd and non-phosphorylated subunits, J. Neurocytol., 20 (1991) 746-758.
34. Rosenbluth, J., The fine structure of the acoustic ganglia in the rat, J. Cell Biol., 12 (1962) 325-359.
35. Rosenfeld, J., Dorman, M.E., Griffin, J.W., Gold, B.G., Sternberger, L.A., Sternberger, N.H. and Price, D.L., Distribution of neurofilament antigens after axonal injury. J. Neuropathol. Exp. Neurol., 46 (1987) 269-282.
36. Shaw, G., Osborn, M. and Weber, K., Reactivity of a panel of neurofilament antibodies on phosphorylated and dephosphorylated neurofilaments, Eur. J. Cell Biol., 42 (1986) 1-9.
37. Spencer, P.S. and Schaumburg, H.H., Ultrastructural studies of the dying-back process. III. The evolution of experimental peripheral giant axonal degeneration. J. Neuropathol. Exp. Neurol., 36 (1977) 276-299.
38. Xu, Z., Cork, L.C., Griffin, J.W. and Cleveland, D.W., Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell, 73 (1993) 23-33.