Role of cytochrome P-450 2E1 in methacrylonitrile metabolism and disposition

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 2, 1999, Pages 1054-1059

  Ghanayem, Burhan I ^a   Sanders, J Michael ^a   Chanas, Brian ^a   Burka, Leo T ^a   Gonzalez, Frank J ^b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOBENZOTRIAZOLE; ACETYLCYSTEINE; CARBON DIOXIDE; CYTOCHROME P450; EPOXIDE; GLUTATHIONE; METHACRYLONITRILE;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; CONFERENCE PAPER; DEGRADATION; DRUG DISPOSITION; EXCRETION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

ACETYLCYSTEINE; ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2E1; FECES; FEMALE; MALE; METHACRYLATES; MICE; MICE, KNOCKOUT; NITRILES; OXIDATION-REDUCTION; TISSUE DISTRIBUTION;

EID: 0032901786     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (25)

1. Abreu ME and Ahmed AE (1980) Metabolism of acrylonitrile to cyanide: In vitro studies. Drug Metab Dispos 8:376-379.
2. Budavari S ed (1989) The Merck Index, 11th ed. Merck and Co., Rahway, NJ.
3. Burka LT, Sanchez MI, Ahmed AE and Ghanayem BI (1994) Comparative metabolism and disposition of acrylonitrile and methacrylonitrile in rats. Arch Toxicol 68:611-618.
4. Farooqui MYH and Mumtaz MM (1991) Toxicology of methacrylonitrile. Toxicology 65:239-250.
5. Farooqui MYH and Villarreal MI (1992) Maternal toxicity of methacrylonitrile in Sprague-Dawley rats. Bull Environ Contam Toxicol 48:696-700.
6. Ghanayem BI, Boor PJ and Ahmed AE (1985) Acrylonitrile-induced gastric lesions: role of gastric glutathione. J Pharmacol Exp Ther 232:570-577.
7. Ghanayem BI and Burka LT (1996) Excretion and identification of methacrylonitrile metabolites in the bile of male F344 rats. Drug Metab Dispos 24:390-394.
8. Ghanayem BI, Sanchez IM and Burka LT (1992) Effects of dose, strain and dosing vehicle on methacrylonitrile disposition in rats and identification of a novel exhaled metabolite. Drug Metab Dispos 20:643-652.
9. Ghanayem BI, Sanchez MI and Burka LT (1994) Investigation of the metabolic basis for the differences in methacrylonitrile acute toxicity in rats and mice. J Pharmacol Exp Ther 269:581-588.
10. George JD, Price CJ, Marr MC, Myers CB, Schwetz BA, Heindel JJ and Hunter ES (1996) Evaluation of the developmental toxicity of methacrylonitrile in Sprague-Dawley rats and New Zealand White rabbits. Fundam Appl Toxicol 34:249-259.
11. Guengerich FP, Geiger LE, Hogy LL, and Wright PL (1981) In vitro metabolism of acrylonitrile to 2-cyanoethylene oxide, reaction with glutathione and irreversible binding to proteins and nucleic acids. Cancer Res 41:4925-4933.
12. Guengerich FP, Kim DH and Iwasaki M (1991) Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 4:168-179.
13. Hogy LL and Guengerich FP (1986) In vivo interaction of acrylonitrile and 2-cyanoethylene oxide with DNA in rats. Cancer Res 46:3932-3938.
14. Kedderis GL, Batar R and Koop DR (1993) Epoxidation of acrylonitrile by rat and human cytochrome P450. Chem Res Toxicol 6:866-871.
15. Lee SST, Buters JTM, Pineau T, Fernandez-Salguero P and Gonzalez FJ (1996) Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 271:12063-12067.
16. McOmie WA (1949) Comparative toxicity of methacrylonitrile and acrylonitrile. J Ind Hyg Toxicol 31:113-116.
17. Pozzani UC, Kinkead ER and King JM (1968) The mammalian toxicity of methacrylonitrile. J Am Ind Hyg Assoc 29:202-210.
18. Recio L and Skopec TR (1988) Mutagenicity of acrylonitrile and its metabolite 2-cyanoethylene oxide in human lymphoblasts in vitro. Mutat Res 206:297-305.
19. Roberts AE, Kedderis GL, Turner MJ, Rickert DE and Swenberg JA (1991) Species comparison of acrylonitrile epoxidation by microsomes from mice, rats, and humans: Relationship to epoxide concentrations in mouse and rat blood. Carcinogenesis 12:401-404.
20. Smyth HF, Carpenter CP, Weil CS, Pozzani UC and Streigel JA (1962) Range finding toxicity data. J Am Ind Hyg Assoc 23:95-108.
21. Tanii H and Hashimoto K (1984) Studies on the mechanism of acute toxicity of nitriles in mice. Arch Toxicol 55:47-54.
22. U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry (1990) Taxicological Profile for Acrylonitrile. TP-90-1 Washington, D.C.
23. U.S. Department of Health and Human Services, National Institutes of Health (1985) Guide of the Care and Use of Laboratory Animals. NIH Publication no. 86-23, National Institutes of Health, Bethesda, MD.
24. U.S. Environmental Protection Agency (1983) Health Assessment Document for Acrylonitrile. EPA-600/8-82-007F, US Environmental Protection Agency, Washington, DC.
25. World Health Organization (1983) Acrylonitrile. Environmental Health Criteria no. 28, World Health Organization, Geneva.