Cerebellar fastigial nuclear inputs and peripheral feeding signals converge on neurons in the dorsomedial hypothalamic nucleus

NeuroSignals

Volumn 17, Issue 2, 2009, Pages 132-143

  Li, Bin ^a   Guo, Chun Li ^a   Tang, Jing ^a   Zhu, Jing Ning ^a   Wang, Jian Jun ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Cerebellar fastigial nucleus; Cerebellohypothalamic projections; Dorsomedial hypothalamic nucleus; Feeding control; Gastric vagal nerves; Glycemia; Leptin

Indexed keywords

GLUCOSE; LEPTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBELLUM NUCLEUS; CONTROLLED STUDY; FASTIGIAL NUCLEUS; FEEDING; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HYPOTHALAMUS NUCLEUS; IN VIVO STUDY; INTEGRATION; MALE; NERVE PROJECTION; NERVE STIMULATION; NONHUMAN; RAT; SENSORY NERVE; SOMATOSENSORY CORTEX; VAGUS NERVE; VAGUS NERVE STIMULATION; VISCERA;

ACTION POTENTIALS; ANIMALS; BLOOD GLUCOSE; CEREBELLAR NUCLEI; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; EATING; ELECTRIC STIMULATION; FEMALE; GLUCOSE; LEPTIN; MALE; MANNITOL; MICROELECTRODES; NEURAL PATHWAYS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SWEETENING AGENTS; VAGUS NERVE STIMULATION;

EID: 58949092975     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000197913     Document Type: Article

References (60)

1. Bellinger LL, Bernardis LL: The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation: lessons learned from lesioning studies. Physiol Behav 2002; 76: 431-442.
2. Zhu JN, Guo CL, Li HZ, Wang JJ: Dorsomedial hypothalamic nucleus neurons integrate important peripheral feeding-related signals in rats. J Neurosci Res 2007; 85:3193-3204.
3. Fuller PM, Lu J, Saper CB: Differential rescue of light- and food-entrainable circadian rhythms. Science 2008; 320:1074-1077.
4. Gooley JJ, Schomer A, Saper CB: The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms. Nat Neurosci 2006; 9:398-407.
5. Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J: Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci 2003; 23:10691-10702.
6. Friedman JM, Halaas JL: Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763-770.
7. Bray GA: Afferent signals regulating food intake. Proc Nutr Soc 2000; 59:373-384.
8. Schwartz GJ: The role of gastrointestinal vagal afferents in the control of food intake: current prospects. Nutrition 2000; 16:866-873.
9. Campfield LA, Smith FJ: Blood glucose dynamics and control of meal initiation: a pattern detection and recognition theor y. Physiol Rev 2003; 83: 25-58.
10. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG: Central nervous system control of food intake. Nature 2000; 404: 661-671.
11. Elmquist JK, Ahima RS, Elias CF, Flier JS, Saper CB: Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc Natl Acad Sci USA 1998; 95: 741-746.
12. Shioda S, Funahashi H, Nakajo S, Yada T, Maruta O, Nakai Y: Immunohistochemical localization of leptin receptor in the rat bra in. Neurosci Lett 1998; 243: 41-44.
13. Zhu JN, Wang JJ: The cerebellum in feeding control: possible function and mechanism. Cell Mol Neurobiol 2008; 28: 469-478.
14. Scalera G: Effects of corticocerebellar lesions on taste preferences, body weight gain, food and fluid intake in the rat. J Physiol (Paris) 1991; 85:214-222.
15. Mahler JM: An unexpected role of the cerebellum: involvement in nutritional organization. Physiol Behav 1993; 54:1063-1067.
16. Liu YJ, Gao JH, Liu HL, Fox PT: The temporal response of the brain after eating revealed by functional MR I. Nature 2000; 405: 1058 - 1061.
17. Reis DJ, Golanov EV: Autonomic and vasomotor regulation. Int Rev Neurobiol 1997; 41: 121-149.
18. Xu FD, Frazier DT: Modulation of respiratory motor output by cerebellar deep nuclei in the rat. J Appl Physiol 2000; 89:996-1004.
19. Dietrichs E, Haines DE: Possible pathway for cerebellar modulation of autonomic response: micturition. Scand J Urol Nephrol 2002; 210:16-20.
20. Peng YP, Qiu YH, Chao BB, Wang JJ: Effect of lesions of cerebellar fastigial nuclei on lymphocyte functions of rats. Neurosci Res 2005; 51: 275-284.
21. Peng YP, Qiu YH, Qiu J, Wang JJ: Cerebellar interposed nucleus lesions suppress lympho-cyte function in rats. Brain Res Bull 2006; 71: 10-17.
22. Ito M: Cerebellar long-term depression: characterization, signal transduction, and fuctional roles. Physiol Rev 2001; 81: 1143 - 1195.
23. Schmahmann JD, Sherman JC: The cerebellar cognitive affective syndrome. Brain 1998; 121:561-579.
24. Martner J: Cerebellar influences on autonomic mechanisms: An experimental study in the cat with special reference to the fasti-gial nucleus. Acta Physiol Scand 1975; 425: 1-42.
25. Dietrichs E, Haines DE, Røste GK, Røste LS: Hypothalamocerebellar and cerebellohypo-thalamic projections: circuits for regulating nonsomatic cerebellar activity? Histol Histopathol 1994; 9:603-614.
26. Haines DE, Dietrichs E, Mihailoff GA, McDonald EF: The cerebellar-hypothalamic axis: basic circuits and clinical observations. Int Rev Neurobiol 1997; 41:83-107.
27. Çavdar S, Şan T, Aker R, Şehirli U, Onat F: Cerebellar connections to the dorsomedial and posterior nuclei of the hypothalamus in the rat. J Anat 2001; 198:37-45.
28. Çavdar S, Onat F, Aker R, Şehirli U, Şan T, Yananli HR: The afferent connections of the posterior hypothalamic nucleus in the rat using horseradish peroxidase. J Anat 2001; 198:463-472.
29. Wang JJ, Pu YM, Wang T: Influences of cerebellar interpositus nucleus and fastigial nucleus on the neuronal activity of lateral hy-pothalamic area. Sci China C Life Sci 1997; 40: 176-183.
30. Zhang YP, Ma C, Wen YQ, Wang JJ: Convergence of gastric vagal and cerebellar fastigial nuclear inputs on glycemia-sensitive neurons of lateral hypothalamic area in the rat. Neurosci Res 2003; 45:9-16.
31. Min B, Oomura Y, Katafuchi T: Responses of rat lateral hypothalamic neuronal activity to fastigial nucleus stimulation. J Neurophysiol 1989; 61: 1178-1184.
32. Katafuchi T, Koizumi K: Fastigial inputs to paraventricular neurosecretory neurons studied by extra- and intracellular recordings in rats. J Physiol (London) 1990; 421: 535-551.
33. Haywood JR, Fink GD, Buggy J, Phillips MI, Brody MJ: The area postrema plays no role in the pressor action of angiotensin in the rat. Am J Physiol Heart Circ Physiol 1980; 239: H108-H113.
34. Zhang ZH, Felder RB: Melanocortin receptors mediate the excitatory effects of blood-borne murine leptin on hypothalamic para-ventricular neurons in rat. Am J Physiol Regu l Integ r Comp Physiol 2004; 286:R303- R310.
35. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates, ed 4. San Diego, Academic Press, 1998.
36. Yuan CS, Barber WD: Hypothalamic unitary responses to gastric vagal input from the proximal stomach. Am J Physiol Gastrointest Liver Physiol 1992; 262:G74-G80.
37. Yuan CS, Barber WD: Interactions of gastric vagal and peripheral nerves on single neurons of lateral hypothalamus in the cat. Am J Physiol Gastrointest Liver Physiol 1996; 271:G858-G865.
38. Oomura Y, Kimura K, Ooyama H, Maeno T, Iki M, Kuniyoshi M: Reciprocal activities of the ventromedial and lateral hypothalamic areas of cats. Science 1964; 143 : 484-485.
39. Orsini JC, Wiser AK, Himmi T, Boyer A: Sensitivity of lateral hypothalamic neurons to glycemia level: possible involvement of an indirect adrenergic mechanism. Brain Res Bull 1991; 26: 473 - 478.
40. Himmi T, Boyer A, Orsini JC: Changes in lateral hypothalamic neuronal activity accompanying hyper- and hypoglycemias. Physiol Behav 1988; 44:347-354.
41. Yettefti K, Orsini JC, Perrin J: Characteristics of glycemia-sensitive neurons in the nucleus tractus solitarii: possible involvement in nutritional regulation. Physiol Behav 1997; 61: 93-100.
42. Zhang YP, Zhu JN, Chen K, Li HZ, Wang JJ: Neurons in the rat lateral hypothalamic area integrate information from the gastric vagal nerves and the cerebellar interpositus nucleus. Neurosignals 2005; 14 : 234-243.
43. Zhu JN, Zhang YP, Song YN, Wang JJ: Cerebellar interpositus nuclear and gastric vagal afferent inputs reach and converge onto glycemia-sensitive neurons of the ventromedial hypothalamic nucleus in rats. Neurosci Res 2004; 48: 405-417.
44. Zhu JN, Li HZ, Ding Y, Wang JJ: Cerebellar modulation on feeding-related neurons in rat dorsomedial hypothalamic nucleus. J Neurosci Res 2006; 84: 1597-1609.
45. Wen YQ, Zhu JN, Zhang YP, Wang JJ: Cerebellar interpositus nuclear inputs impinge on paraventricular neurons of the hypothalamus in rats. Neurosci Lett 2004; 370:25-29.
46. Kita H, Oomura Y: An HRP study of the afferent connections to rat medial hypothalamic region. Brain Res Bull 1982; 8:53-62.
47. Bernardis LL, Bellinger LL: The dorsomedial hypothalamic nucleus revisited: 1998 update. Proc Soc Exp Biol Med 1998; 218:284-306.
48. Zhu JN, Yung WH, Chow BKC, Chan YS, Wang JJ: The cerebellar-hypothalamic circuits: potential pathways underlying cerebellar involvement in somatic-visceral integration. Brain Res Rev 2006; 52: 93-106.
49. Colombel C, Lalonde R, Caston J: The effects of unilateral removal of the cerebellar hemispheres on motor functions and weight gain in rats. Brain Res 2002; 950:231-238.
50. Schmahmann JD, Doyon J, McDonald D, Holmes C, Lavoie K, Hurwitz AS, Kabani N, Toga A, Evans A, Petrides M: Three-dimensional MRI atlas of the cerebellum in proportional stereotaxic space. NeuroImage 1999; 10: 233-260.
51. Tataranni PA, Gautier JF, Chen K, Uecker A, Bandy D, Salbe AD, Pratley RE, Lawson M, Reiman EM, Ravussin E: Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography. Proc Natl Acad Sci USA 1999; 96:4569-4574.
52. Parsons LM, Denton D, Enga G, McKinley M, Shade R, Lancaster J, Fox PT: Neuroimaging evidence implicating cerebellum in support of sensory/cognitive processes associated with thirst. Proc Natl Acad Sci USA 2000; 97:2332-2334.
53. Pu YM, Wang JJ, Wang T, Yu QX: Cerebellar interpositus nucleus modulates neuronal activity of lateral hypothalamic area. Neuro-Report 1995; 6:985-988.
54. Gzgzian DM, Kuzina MM, Tanasiǐchuk OF: Effect of the cerebellum on the motor activity of the stomach in the scorpionfish, Scorpaena porcus . Zh Evol Biokhim Fiziol 1978; 14 : 408-410.
55. Lam QL, Lu L: Role of leptin in immunity. Cell Mol Immunol 2007; 4:1-13.
56. Paraskevas KI, Liapis CD, Mikhailidis DP: Leptin: a promising therapeutic target with pleiotropic action besides body weight regulation. Curr Drug Targets 2006; 7:761-771.
57. Holzer P: Role of visceral afferent neurons in mucosal inflammation and defense. Curr Opin Pharmacol 2007; 7:563-569.
58. Turina M, Miller FN, Tucker C, Polk HC: Effects of hyperglycemia, hyperinsulinemia, and hyperosmolarity on neutrophil apoptosis. Surg Infect (Larchmt) 2006; 7:111-121.
59. Milak MS, Shimansky Y, Bracha V, Bloedel JR: Effects of inactivating individual cerebellar nuclei on the performance and retention of an operantly conditioned forelimb movement. J Neurophysiol 1997; 78: 939-959.
60. Martin JH, Cooper SE, Hacking A, Ghez C: Differential effects of deep cerebellar nuclei inactivation on reaching and adaptive control. J Neurophysiol 2000; 83: 1886 - 1899.