Dorsomedial hypothalamic nucleus neurons integrate important peripheral feeding-related signals in rats

Journal of Neuroscience Research

Volumn 85, Issue 14, 2007, Pages 3193-3204

  Zhu, Jing Ning ^a   Guo, Chun Li ^a   Li, Hong Zhao ^a   Wang, Jian Jun ^a,b  

^a NANJING UNIVERSITY   (China)

^b NANJING NORMAL UNIVERSITY   (China)

Author keywords

Dorsomedial hypothalamic nucleus; Feeding regulation; Gastric vagal nerves; Glycemia sensitive neurons; Leptin

Indexed keywords

CHOLECYSTOKININ; GLUCOSE; LEPTIN; MANNITOL; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEEDING; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HYPOTHALAMUS NUCLEUS; MALE; METABOLIC RATE; NERVE CELL; NERVE POTENTIAL; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VAGUS NERVE;

ACTION POTENTIALS; AFFERENT PATHWAYS; ANIMALS; CHOLECYSTOKININ; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; DOSE-RESPONSE RELATIONSHIP, RADIATION; DRUG INTERACTIONS; ELECTRIC STIMULATION; FEEDING BEHAVIOR; FEMALE; GLUCOSE; LEPTIN; MALE; NEURAL INHIBITION; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; VAGUS NERVE;

EID: 35848949764     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21420     Document Type: Article

References (39)

1. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizi L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJ. 1998. The stomach is a source of leptin. Nature 394:790-793.
2. Bagdan B, Pittman QJ. 1995. Responses of electrophysiologically identified rat paraventricular neurons to cholecystokinin and other stimuli. Neuroscience 65:869-878.
3. Bellinger LL, Bernardis LL. 2002. The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation: Lessons learned from lesioning studies. Physiol Behav 76:431-442.
4. Bernardis LL, Bellinger LL. 1998. The dorsomedial hypothalamic nucleus revisited: 1998 update. Proc Soc Exp Biol Med 218:284-306.
5. Bray GA. 2000. Afferent signals regulating food intake. Proc Nutr Soc 59:373-384.
6. Campfield LA, Smith FJ. 2003. Blood glucose dynamics and control of meal initiation: a pattern detection and recognition theory. Physiol Rev 83:25-58.
7. Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J. 2003. Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci 23:10691-10702.
8. Elmquist JK, Ahima RS, Elias CF, Flier JS, Saper CB. 1998. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc Natl Acad Sci U S A 95:741-746.
9. Friedman JM, Halaas JL. 1998. Leptin and the regulation of body weight in mammals. Nature 395:763-770.
10. Funahashi H, Yada T, Muroya S, Takigawa M, Ryushi T, Horie S, Nakai Y, Shioda S. 1999. The effect of leptin on feeding-regulating neurons in the rat hypothalamus. Neurosci Lett 264:117-120.
11. Gooley JJ, Schomer A, Saper CB. 2006. The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms. Nat Neurosci 9:398-407.
12. Haywood JR, Fink GD, Buggy J, Phillips MI, Brody MJ. 1980. The area postrema plays no role in the pressor action of angiotensin in the rat. Am J Physiol Heart Circ Physiol 239:H108-H113.
13. Himmi T, Boyer A, Orsini JC. 1988. Changes in lateral hypothalamic neuronal activity accompanying hyper- and hypoglycemias. Physiol Behav 44:347-354.
14. Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS. 1999. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 20:68-100.
15. Kita H, Oomura Y. 1982. An HRP study of the afferent connections to rat medial hypothalamic region. Brain Res Bull 8:53-62.
16. Levin BE, Dunn-Meynell AA, Routh VH. 1999. Brain glucose sensing and body energy homeostasis: role in obesity and diabetes. Am J Physiol Regul Integr Comp Physiol 276:R1223-R1231.
17. Lou JS, Bloedel JR. 1986. The responses of simultaneously recorded Purkinje cells to the perturbations of the step cycle in the walking ferret: a study using a new analytical method: the real-time postsynaptic response (RTPR). Brain Res 365:340-344.
18. Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP. 1999. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol Rev 51:745-781.
19. Oomura Y, Kimura K, Ooyama H, Maeno T, Iki M, Kuniyoshi M. 1964. Reciprocal activities of the ventromedial and lateral hypothalamic areas of cats. Science 143:484-485.
20. Orsini JC, Wiser AK, Himmi T, Boyer A. 1991. Sensitivity of lateral hypothalamic neurons to glycemia level: possible involvement of an indirect adrenergic mechanism. Brain Res Bull 26:473-478.
21. Paxinos G, Waston C. 1998. The Rat Brain in Stereotaxic Coordinates.4th ed. San Diego: Academic Press.
22. Peters JH, McKay BM, Simasko SM, Ritter RC. 2005. Leptin-induced satiation mediated by abdominal vagal afferents. Am J Physiol Regul Integr Comp Physiol 288:R879-R884.
23. Renaud LP, Tang M, McCann MJ, Stricker EM, Verbalis JG. 1987. Cholecystokinin and gastric distension activate oxytocinergic cells in rat hypothalamus. Am J Physiol Regul Integr Comp Physiol 253:R661-R665.
24. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. 2000. Central nervous system control of food intake. Nature 404:661-671.
25. Schwartz GJ. 2000. The role of gastrointestinal vagal afferents in the control of food intake: current prospects. Nutrition 16:866-873.
26. Shioda S, Funahashi H, Nakajo S, Yada T, Maruta O, Nakai Y. 1998. Immunohistochemical localization of leptin receptor in the rat brain. Neurosci Lett 243:41-44.
27. Shiraishi T, Oomura Y, Sasaki K, Wayner MJ. 2000. Effects of leptin and orexin-A on food intake and feeding related hypothalamic neurons. Physiol Behav 71:251-261.
28. Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford ML. 1997. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390:521-525.
29. Thompson RH, Canteras NS, Swanson LW. 1996. Organization of projections from the dorsomedial nucleus of the hypothalamus: a PHA-L study in the rat. J Comp Neurol 376:143-173.
30. Thompson RH, Swanson LW. 1998. Organization of inputs to the dorsomedial nucleus of the hypothalamus: a reexamination with Fluorogold and PHAL in the rat. Brain Res Brain Res Rev 27:89-118.
31. Yettefti K, Orsini JC, Perrin J. 1997. Characteristics of glycemia-sensitive neurons in the nucleus tractus solitarii: possible involvement in nutritional regulation. Physiol Behav 61:93-100.
32. Yuan CS, Barber WD. 1992. Hypothalamic unitary responses to gastric vagal input from the proximal stomach. Am J Physiol Gastrointest Liver Physiol 262:G74-G80.
33. Yuan CS, Barber WD. 1996. Interaction of gastric vagal and peripheral nerves on single neurons of lateral hypothalamus in the cat. Am J Physiol Gastrointest Liver Physiol 271:G858-G865.
34. Zhang YP, Ma C, Wen YQ, Wang JJ. 2003. Convergence of gastric vagal and cerebellar fastigial nuclear inputs on glycemia-sensitive neurons of lateral hypothalamic area in the rat. Neurosci Res 45:9-16.
35. Zhang YP, Zhu JN, Chen K, Li HZ, Wang JJ. 2005. Neurons in the rat lateral hypothalamic area integrate information from the gastric vagal nerves and the cerebellar interpositus nucleus. Neurosignals 14:234-243.
36. Zhang ZH, Felder RB. 2004. Melanocortin receptors mediate the excitatory effects of blood-borne murine leptin on hypothalamic paraventricular neurons in rat. Am J Physiol Regul Integr Comp Physiol 286:R303-R310.
37. Zhu JN, Zhang YP, Song YN, Wang JJ. 2004. Cerebellar interpositus nuclear and gastric vagal afferent inputs reach and converge onto glycemia-sensitive neurons of the ventromedial hypothalamic nucleus in rats. Neurosci Res 48:405-417.
38. Zhu JN, Li HZ, Ding Y, Wang JJ. 2006a. Cerebellar modulation on feeding-related neurons in rat dorsomedial hypothalamic nucleus. J Neurosci Res 84:1597-1609.
39. Zhu JN, Yung WH, Chow BKC, Chan YS, Wang JJ. 2006b. The cerebellar-hypothalamic circuits: potential pathways underlying cerebellar involvement in somatic-visceral integration. Brain Res Brain Res Rev 52:93-106.