Seizures and status epilepticus in the intensive care unit

Seminars in Neurology

Volumn 28, Issue 5, 2008, Pages 668-681

  Ziai, Wendy C ^a,b   Kaplan, Peter W ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Intensive care; Neurological emergencies; Nonconvulsive status epilepticus; Refractory status epilepticus; Status epilepticus

Indexed keywords

ACETAZOLAMIDE; ANTICONVULSIVE AGENT; BENZODIAZEPINE; CLOBAZAM; CORTICOSTEROID; DIAZEPAM; ETIRACETAM; FOSPHENYTOIN SODIUM; ISOFLURANE; KETAMINE; LAMOTRIGINE; LORAZEPAM; METHYLPHENIDATE; MIDAZOLAM; PENTOBARBITAL; PHENOBARBITAL; PHENYTOIN; PROPOFOL; ROCURONIUM; SUXAMETHONIUM; THIAMINE; THIOPENTAL; TOPIRAMATE; VALPROIC ACID; VECURONIUM;

ALGORITHM; BONE MARROW SUPPRESSION; CLINICAL TRIAL; CONSULTATION; DIFFERENTIAL DIAGNOSIS; DISEASE ACTIVITY; DISEASE DURATION; ELECTROENCEPHALOGRAPHY; EPILEPTIC STATE; HEMORRHAGIC PANCREATITIS; HUMAN; HYPERAMMONEMIA; HYPOTENSION; INTENSIVE CARE UNIT; LIVER FAILURE; LIVER TOXICITY; LOADING DRUG DOSE; MEDICAL LITERATURE; PARKINSONISM; PRIORITY JOURNAL; PURPLE GLOVE SYNDROME; QT PROLONGATION; RECURRENT DISEASE; RESPIRATION DEPRESSION; REVIEW; SEDATION; SEIZURE; SIDE EFFECT; SYNDROME; THROMBOCYTOPENIA; UNSPECIFIED SIDE EFFECT;

ANTICONVULSANTS; CLINICAL PROTOCOLS; COMA; ELECTROENCEPHALOGRAPHY; EVENT-RELATED POTENTIALS, P300; HUMANS; INTENSIVE CARE; INTENSIVE CARE UNITS; SEIZURES; STATUS EPILEPTICUS;

EID: 58949090660     PISSN: 02718235     EISSN: 10989021     Source Type: Journal    
DOI: 10.1055/s-0028-1105978     Document Type: Review

References (129)

1. Bleck TP, Smith MC, Pierre-Louis SJ, Jares JJ, Murray J, Hansen CA. Neurologic complications of critical medical illnesses. Crit Care Med 1993;21(1):98-103
2. Varelas PN, Mirski MA. Seizures in the adult intensive care unit. J Neurosurg Anesthesiol 2001;13(2):163-175
3. Lowenstein DH, Alldredge BK. Status epilepticus at an urban public hospital in the 1980s. Neurology 1993;43:483-488
4. Aminoff MJ, Simon RP. Status epilepticus: causes, clinical features and consequences in 98 patients. Am J Med 1980;69:657-666
5. Barry E, Hauser WA. Status epilepticus: the interaction of epilepsy and acute brain disease. Neurology 1993;43:1473-1478
6. Delanty N, French JA, Labar DR, et al. Status epilepticus arising de novo in hospitalized patients: an analysis of 41 patients. Seizure 2001;10:116-119
7. DeLorenzo RJ, Hauser WA, Towne AR, et al. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology 1996;46:1029-1035
8. Towne AR, Waterhouse EJ, Boggs JG, et al. Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology 2000;54:340-345
9. Jordan KG. Continuous EEG and evoked potential monitoring in the neuroscience intensive care unit. J Clin Neurophysiol 1993;10:445-475
10. Ozuna J. Seizure disorders and epilepsy. Lippincotts Prim Care Pract 2000;4(6):608-618
11. Lowenstein DH, Bleck T, Macdonald RL. It's time to revise the definition of status epilepticus. Epilepsia 1999;40:120-122
12. Gastaut H. Classification of status epilepticus. In: Delgado-Escueta AV, Wasterlain CG, Treiman DM, Porter RJ, eds. Status Epilepticus. New York: Raven Press; 1983: 15-35
13. Fagan KJ, Lee SI. Prolonged confusion following convulsions due to generalized nonconvulsive status epilepticus. Neurology 1990;40:1689-1694
14. Mikati MA, Lee WL, DeLong GR. Protracted epileptiform encephalopathy: an unusual form of partial complex status epilepticus. Epilepsia 1985;26:563-571
15. Kaplan PW. Nonconvulsive status epilepticus. Semin Neurol 1996;16:33-40
16. Abou Khaled KJ, Hirsch LJ. Updates in the management of seizures and status epilepticus in critically ill patients. Neurol Clin 2008;26:385-408
17. Kaplan PW. Behavioral manifestations of nonconvulsive status epilepticus. Epilepsy Behav 2002;3:122-139
18. Kaplan PW. Nonconvulsive status epilepticus in the emergency room. Epilepsia 1996;37:643-650
19. Dunne JW, Summers QA, Stewart-Wynne EG. Nonconvulsive status epilepticus: a prospective study in an adult general hospital. Q J Med 1987;62:117-126
20. Arif H, Hirsch LJ. Treatment of status epilepticus. Semin Neurol 2008;28(3):342-354
21. Thomas P, Beaumanoir A, Genton P, et al. "De novo" absence status of late onset: report of 11 cases. Neurology 1992;42:104-110
22. Kaplan PW. Nonconvulsive status in the elderly. Epilepsia 1998;39(suppl 6):122
23. Kaplan PW, ed. Neurologic Disease in Women. New York: Demos Medical Publishing; 1998
24. Kaplan PW. Assessing the outcomes in patients with nonconvulsive status epilepticus: nonconvulsive status epilepticus is underdiagnosed, potentially overtreated, and confounded by comorbidity. J Clin Neurophysiol 1999;16:341-352
25. Shneker BF, Fountain NB. Assessment of acute morbidity and mortality in nonconvulsive status epilepticus. Neurology 2003;61:1066-1073
26. Granner MA, Lee SI. Nonconvulsive status epilepticus: EEG analysis of a large series. Epilepsia 1994;35:42-47
27. Young GB, Goodenough P, Jacono V, Schieven JR. Periodic lateralized epileptiform discharges (PLEDs): electrographic and clinical features. Am J EEG Technol 1988;28:1-13
28. Young GB, Jordan KG, Doig GS. An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology 1996;47:83-89
29. Brenner RP, Schaul N. Periodic EEG patterns: classification, clinical correlation, and pathophysiology. J Clin Neurophysiol 1990;7(2):249-267
30. Chatrian GE, Shaw CM, Leffman H. The significance of periodic lateralized epileptiform discharges in EEG: an electrographic, clinical and pathological study. Electroencephalogr Clin Neurophysiol 1964;17:177-193
31. Snodgrass SM, Tsuburaya K, Ajmone-Marsan C. Clinical significance of periodic lateralized epileptiform discharges: relationship with status epilepticus. J Clin Neurophysiol 1989;6:159-172
32. de la Paz D, Brenner RP. Bilateral independent periodic lateralized epileptiform discharges. Arch Neurol 1981;38:713-715
33. Reiher J, Rivest J, Grand-Maison F, Leduc CP. Periodic lateralized epileptiform discharges with transitional rhythmic discharges: association with seizures. Electroencephalogr Clin Neurophysiol 1991;78:12-17
34. Husain AM, Mebust KA, Radtke RA. Generalized periodic epileptiform discharges: etiologies, relationship to status epilepticus, and prognosis. J Clin Neurophysiol 1999;16:51-58
35. Yemisci M, Gurer G, Saygi S, Ciger A. Generalized periodic epileptiform discharges: clinical features, neuroradiological evaluation and prognosis in 37 adult patients. Seizure 2003;12:465-472
36. Hirsch LJ, Claassen J, Mayer SA, Emerson RG. Stimulus-induced rhythmic periodic or ictal discharges (SIRPIDs): a common EEG phenomenon in the critically ill. Epilepsia 2004;45:109-123
37. Gross DW, Wiebe S, Blume WT. The periodicity of lateralized epileptiform discharges. Clin Neurophysiol 1999;110:1516-1520
38. Pohlmann-Eden B, Hoch DB, Cochius JI, Chiappa KH. Periodic lateralized epileptiform discharges: a critical review. J Clin Neurophysiol 1996;13:519-530
39. Garzon E, Fernandes RMF, Sakamoto AC. Serial EEG during human status epilepticus: evidence for PLED as an ictal pattern. Neurology 2001;57:1175-1183
40. Nagata K, Tagawa K, Hiroi S, Shishido F, Uemura K. Electroencephalographic correlates of blood flow and oxygen metabolism provided by positron emission tomography in patients with cerebral infarction. Electroencephalogr Clin Neurophysiol 1989;72:16-30
41. Theodore WH, Newmark ME, Sato S, et al. (18-F) Fluorodeoxy glucose positron emission tomography in refractory complex partial seizures. Ann Neurol 1983;14:429-437
42. Chong DJ, Hirsch LJ. Which EEG patterns warrant treatment in the critically ill? Reviewing the evidence for treatment of periodic epileptiform discharges and related patterns. J Clin Neurophysiol 2005;22:79-91
43. Boulanger JM, Deacon C, Lecuyer D, Gosselin S, Reiher J. Triphasic waves versus nonconvulsive status epilepticus: EEG distinction. Can J Neurol Sci 2006;33:175-180
44. Nousiainen U, Suomalainen T, Mervaala E. Clinical benefits of scalp EEG studies in intractable seizure disorders. Acta Neurol Scand 1992;85:181-186
45. Lesser RP, Lueders H, Dinner DS. Evidence for epilepsy is rare in patients with psychogenic seizures. Neurology 1983;33:502-504
46. Howell SJL, Owen L, Chadwick DW. Pseudostatus epilepticus. Q J Med 1989;71:507-519
47. Reuber M, Enright SM, Goulding PJ. Postoperative pseudostatus: not everything that shakes is epilepsy. Anaesthesia 2000;55(1):74-78
48. Treiman DM, Meyers PD, Walton NY, et al. A comparison of four treatments for generalized convulsive status epilepticus. N Engl J Med 1998;339:792-798
49. Nei M, Lee JM, Shanker VL, et al. The EEG and prognosis in status epilepticus. Epilepsia 1999;40(2):157-163
50. Privitera M, Hoffman M, Layne JM, Jester D. EEG detection of nontonic-clonic status epilepticus in patients with altered consciousness. Epilepsy Res 1994;18:155-166
51. Thibodeau LG, Ferrera PC. Nonconvulsive status epilepticus. Am J Emerg Med 1997;15(7):652-653
52. Claassen J, Mayer SA, Kowalski RG, et al. Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology 2004;62:1743-1748
53. Treatment of convulsive status epilepticus. Recommendations of the Epilepsy Foundation of America's Working Group on Status Epilepticus. JAMA 1993;270(7):854-859
54. Bleck TP. Management approaches to prolonged seizures and status epilepticus. Epilepsia 1999;;40(suppl 1):S59-S63; discussion S64-S66
55. Jordan KG. Status epilepticus: a perspective from the neuroscience intensive care unit. Neurosurg Clin N Am 1994;5(4):671-686
56. Pellock JM, Marmarou A, DeLorenzo R. Time to treatment in prolonged seizure episodes. Epilepsy Behav 2004;5(2):192-196
57. Lowenstein DH, Alldredge BK. Status epilepticus at an urban public hospital in the 1980s. Neurology 1993;43(3):483-488
58. Alldredge BK, Gelb AM, Isaacs SM, et al. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med 2001;345(9):631-637
59. Appleton R, Sweeney A, Choonara I, et al. Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. Dev Med Child Neurol 1995;37:682-688
60. Cock HR, Schapira AH. A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus. Q J Med 2002;95:225-231
61. Mayer SA, Claassen J, Lokin J, et al. Refractory status epilepticus: frequency, risk factors, and impact on outcome. Arch Neurol 2002;59:205-210
62. Bauer LA. Interference of oral phenytoin absorption by continuous nasogastric feedings. Neurology 1982;32:570-572
63. Hirsch LJ, Claassen J. The current state of treatment of status epilepticus. Curr Neurol Neurosci Rep 2002;2:345-356
64. Agarwal P, Kumar N, Chandra R, et al. Randomized study of intravenous valproate and phenytoin in status epilepticus. Seizure 2007;16(6):527-532
65. Misra UK, Kalita J, Patel R. Sodium valproate vs phenytoin in status epilepticus: a pilot study. Neurology 2006;67(2):340-342
66. McNamara JO. Drugs effective in the therapy of the epilepsies. In: Hardman JG, Limbird LE, Gilman AG, eds. Goodman & Gilman's The Pharmacologic Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill; 2001:521-547
67. Giroud M, Gras D, Escousse A, et al. Use of injectable valproic acid in status epilepticus: a pilot study. Drug Invest 1993;5:154-159
68. Raskind JY, El-Chaar GM. The role of carnitine supplementation during valproic acid therapy. Ann Pharmacother 2000;34:630-638
69. Sztajnkrycer MD. Valproic acid toxicity: overview and management. J Toxicol Clin Toxicol 2002;40(6):789-801
70. Lheureux PE, Penaloza A, Zahir S, Gris M. Science review: carnitine in the treatment of valproic acid-induced toxicity: what is the evidence? Crit Care 2005;9(5):431-440
71. Tiamkao S, Mayurasakorn N, Suko P, et al. Very high dose phenobarbital for refractory status epilepticus. J Med Assoc Thai 2007;90(12):2597-2600
72. 2+ current in pyramidal neurones of rat hippocampal slices. Neurosci Lett 2001;306:5-8
73. Lee CH, Lee CY, Tsai TS, Liou HH. PKA-mediated phosphorylation is a novel mechanism for levetiracetam, an antiepileptic drug, activating ROMK1 channels. Biochem Pharmacol 2008;76(2):225-235
74. Knake S, Gruener J, Hatteme K, et al. Intravenous levetiracetam in the treatment of benzodiazepine-refractory status epilepticus. J Neurol Neurosurg Psychiatry 2008;79(5):588-589
75. Rossetti AO, Bromfield EB. Levetiracetam in the treatment of status epilepticus in adults: a study of 13 episodes. Eur Neurol 2005;54:34-38
76. Rossetti AO, Bromfield EB. Determinants of success in the use of oral levetiracetam in status epilepticus. Epilepsy Behav 2006;8:651-654
77. Patel NC, Landan IR, Levin J, Szaflarski J, Wilner AN. The use of levetiracetam in refractory status epilepticus. Seizure 2006;15(3):137-141
78. Ramael S, Daoust A, Otoul C, et al. Levetiracetam intravenous infusion: a randomized placebo-controlled safety and pharmacokinetic study. Epilepsia 2006;47:1128-1135
79. Holtkamp M, Othman J, Buchhheim K, et al. Predictors and prognosis of refractory status epilepticus treated in a neurological intensive care unit. J Neurol Neurosurg Psychiatry 2005;76:534-539
80. Rossetti AO, Logroscino G, Bromfield EB. Refractory status epilepticus: effect of treatment aggressiveness on prognosis. Arch Neurol 2005;62:1698-1702
81. Scorza FA, Colugnati DB, Pansani AP, Sonoda EY, Arida RM, Cavalheiro EA. Preventing tomorrow's sudden cardiac death in epilepsy today: what should physicians know about this? Clinics 2008;63(3):389-394
82. Clark LP, Prout TP. Status epilepticus: a clinical and pathological study in epilepsy. (An article in 3 parts). Am J Insanity 1903;60:291-30660:645- 67561:81-108
83. Chen JW, Naylor DE, Wasterlain CG. Advances in the pathophysiology of status epilepticus. Acta Neurol Scand Suppl 2007;186:7-15
84. Mazarati AM, Wasterlain CG. N-Methyl-D-asparate receptor antagonists abolish the maintenance phase of self-sustaining status epilepticus in rat. Neurosci Lett 1999;265:187-190
85. Wasterlain CG, Mazarati AM, Naylor D, et al. Short-term plasticity of hippocampal neuropeptides and neuronal circuitry in experimental status epilepticus. Epilepsia 2002;43(suppl 5):20-29
86. Mazarati AM, Baldwin RA, Sankar R, Wasterlain CG. Time-dependent decrease in the effectiveness of antiepileptic drugs during the course of self-sustaining status epilepticus. Brain Res 1998;814:179-185
87. Kapur J, Macdonald RL. Rapid seizure-induced reduction of benzodiazepine and Zn2+sensitivity of hippocampal dentate granule cell GABAA receptors. J Neurosci 1997;17:7532-7540
88. Wasterlain CG, Liu H, Mazarati A, Baldwin RA. NMDA receptor trafficking during the transition from single seizures to status epilepticus. Ann Neurol 2002;52(suppl 1):S16
89. Bleck TP. Management approaches to prolonged seizures and status epilepticus. Epilepsia 1999;40(suppl 1):S59-S63
90. Claassen J, Hirsch LJ, Emerson RG, Mayer SA. Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review. Epilepsia 2002;43:146-153
91. Wessen A, Persson PM, Nilsson A, Hartvig P. Clinical pharmacokinetics of propofol given as a constant-rate infusion and in combination with epidural blockade. J Clin Anesth 1994;6:193-198
92. Marik PE. Propofol: therapeutic indications and side-effects. Curr Pharm Des 2004;10:3639-3649
93. Holtkamp M. The anaesthetic and intensive care of status epilepticus. Curr Opin Neurol 2007;20:188-193
94. Lowenstein DH, Alldredge BK. Status epilepticus. N Engl J Med 1998;338:970-976
95. Chen JWY, Wasterlain CG. Status epilepticus: pathophysiology and management in adults. Lancet Neurol 2006;5:246-256
96. Finley GA, MacManus B, Sampson SE, Fernandez CV, Retallick R. Delayed seizures following sedation with propofol. Can J Anaesth 1993;40:863-865
97. Kumar MA, Urrutia VC, Thomas CE, Abou-Khaled KJ, Schwartzman RJ. The syndrome of irreversible acidosis after prolonged propofol infusion. Neurocrit Care 2005;3(3):257-259
98. Zarovnaya EL, Jobst BC, Harris BT. Propofol-associated fatal myocardial failure and rhabdomyolysis in an adult with status epilepticus. Epilepsia 2007;48(5):1002-1006
99. Kam PC, Cardone D. Propofol infusion syndrome. Anaesthesia 2007;62(7):690-701
100. Rossetti AO, Reichhart MD, Schaller MD, Despland PA, Bogousslavsky J. Propofol treatment of refractory status epilepticus: a study of 31 episodes. Epilepsia 2004;45:757-763
101. Rogawski MA, Loscher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci 2004;5:553-564
102. Humar M, Pischke SE, Loop T, et al. Barbiturates directly inhibit the calmodulin/calcineurin complex: a novel mechanism of inhibition of nuclear factor of activated T cells. Mol Pharmacol 2004;65(2):350-361
103. Mewasingh LD, Sekhara T, Aeby A, et al. Oral ketamine in paediatric non-convulsive status epilepticus. Seizure 2003;12:483-489
104. Ubogu EE, Sagar SM, Lerner AJ, et al. Ketamine for refractory status epilepticus: a case of possible ketamine-induced neurotoxicity. Epilepsy Behav 2003;4:70-75
105. Borris DJ, Bertram EH, Kapur J. Ketamine controls prolonged status epilepticus. Epilepsy Res 2000;42:117-122
106. Walker IA, Slovis CM. Lidocaine in the treatment of status epilepticus. Acad Emerg Med 1997;4:918-922
107. Mirsattari SM, Sharpe MD, Young GB. Treatment of refractory status epilepticus with inhalational anesthetic agents isoflurane and desflurane. Arch Neurol 2004;61:1254-1259
108. Kofke WA, Young RS, Davis P, et al. Isoflurane for refractory status epilepticus: a clinical series. Anesthesiology 1989;71:653-659
109. Koblin DD. Characteristics and implications of desflurane metabolism and toxicity. Anesth Analg 1992;75:S10-S16
110. Towne AR, Garnett LK, Waterhouse EJ, et al. The use of topiramate in refractory status epilepticus. Neurology 2003;60:332-334
111. Krishnamurthy KB, Drislane FW. Relapse and survival after barbiturate anesthetic treatment of refractory status epilepticus. Epilepsia 1996;37:863-867
112. Holtkamp M, Othman J, Buchheim K, Masuhr F, Schielke E, Meierkord H. A malignant" variant of status epilepticus. Arch Neurol 2005;62(9):1428-1431
113. Sheth RD, Gidal BE. Refractory status epilepticus: response to ketamine. Neurology 1998;51:1765-1766
114. Prüss H, Holtkamp M. Ketamine successfully terminates malignant status epilepticus. Epilepsy Res 2008; September 17 (Epub ahead of print)
115. Krumholz A, Sung GY, Fisher RS, et al. Complex partial status epilepticus accompanied by serious morbidity and mortality. Neurology 1995;45:1499-1504
116. Kaplan PW. Intravenous valproate treatment of generalized nonconvulsive status epilepticus. Clin Electroencephalogr 1999;30:1-4
117. Winston KR, Levisohn P, Miller BR, Freeman J. Vagal nerve stimulation for status epilepticus. Pediatr Neurosurg 2001;34:190-192
118. Bae EH, Schrader LM, Machii K, et al. Safety and tolerability of repetitive transcranial magnetic stimulation in patients with epilepsy: a review of the literature. Epilepsy Behav 2007;10(4):521-528
119. Carrasco Gonzales MD, Palomar M, Rovira R. Electro-convulsive therapy for status epilepticus. [letter] Ann Intern Med 1997;127:247-248
120. Lousa M, Sanchez-Alonso S, Rodriguez-Diaz R, Dalmau J. Status epilepticus with neuron-reactive serum antibodies: response to plasma exchange. Neurology 2000;54:2163-2165
121. Gorman DG, Shields WD, Shewmon DA, et al. Neurosurgical treatment of refractory status epilepticus. Epilepsia 1992;33:546-549
122. Corry JJ, Dhar R,Murphy T,DiringerMN. Hypothermia for refractory status epilepticus. Neurocrit Care 2008;9(2):189-197
123. Woodhall B, Sealy WC, Hall KD, Floyd WL. Craniotomy under conditions of quinidine-protected cardioplegia and profound hypothermia. Ann Surg 1960;152:37-44
124. Costello DJ, Cole AJ. Treatment of acute seizures and status epilepticus. J Intensive Care Med 2007;22(6):319-347
125. Hesdorffer DC, Logroscino G, Cascino G, et al. Incidence of status epilepticus in Rochester, Minnesota, 1965-1984. Neurology 1998;50:735-741
126. DeLorenzo RJ, HauserWA, Towne AR, et al. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology 1996;46:1029-1035
127. Legriel S, Mourvillier B, Bele N, et al. Outcomes in 140 critically ill patients with status epilepticus. Intensive Care Med 2008;34(3):476-480
128. Towne AR, Pellock JM, Ko D, et al. Determinants of mortality in status epilepticus. Epilepsia 1994;35:27-34
129. Holtkamp M, Othman J, Buchheim K, Meierkord H. Predictors and prognosis of refractory status epilepticus treated in a neurological intensive care unit. J Neurol Neurosurg Psychiatry 2005;76(4):534-539