Barbiturates Directly Inhibit the Calmodulin/Calcineurin Complex: A Novel Mechanism of Inhibition of Nuclear Factor of Activated T Cells

Molecular Pharmacology

Volumn 65, Issue 2, 2004, Pages 350-361

  Humar, Matjaz ^c   Pischke, Soeren E ^a   Loop, Torsten ^a   Hoetzel, Alexander ^a   Schmidt, Rene ^a   Klaas, Christoph ^b   Pahl, Heike L ^a   Geiger, Klaus K ^a   Pannen, Benedikt H J ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c Anaesthesiologische Univ Klin ^*

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; [3 (3,4 DICHLOROBENZYLAMINO)PROPYL](DIETHOXYMETHYL)PHOSPHINIC ACID; BARBITURIC ACID DERIVATIVE; BICUCULLINE; CALCINEURIN; CALMODULIN; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOSPORIN A; CYTOKINE; DIALURIC ACID; DNA BINDING PROTEIN; ENZYME INHIBITOR; GAMMA INTERFERON; INTERLEUKIN 2; IONOMYCIN; LUCIFERASE; NUCLEAR PROTEIN; OCTAMER TRANSCRIPTION FACTOR 1; PENTOBARBITAL; SECOBARBITAL; TACROLIMUS; THIAMYLAL; THIOBARBITURIC ACID; THIOPENTAL; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NF AT; TRANSCRIPTION FACTOR NF-AT; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DNA BINDING; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; GENE CONTROL; GENETICS; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOSUPPRESSIVE TREATMENT; INFECTION RISK; INTRACRANIAL HYPERTENSION; LEUKEMIA CELL LINE; LYMPHOCYTE; METABOLISM; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; REPORTER GENE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

BARBITURATES; CALCINEURIN; CALMODULIN; CYTOKINES; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; JURKAT CELLS; LYMPHOCYTES; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS;

EID: 1642538958     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.2.350     Document Type: Article

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