Updates in the Management of Seizures and Status Epilepticus in Critically Ill Patients

Neurologic Clinics

Volumn 26, Issue 2, 2008, Pages 385-408

  Abou Khaled, Karine J ^a   Hirsch, Lawrence J ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; AMIKACIN; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CLONAZEPAM; CYCLOSPORIN; DIAZEPAM; ETIRACETAM; FOSPHENYTOIN SODIUM; HYPERTENSIVE FACTOR; IMMUNOGLOBULIN; LIDOCAINE; LORAZEPAM; MEROPENEM; MIDAZOLAM; PENTOBARBITAL; PHENYTOIN; PROPOFOL; THIAMINE; THIOPENTAL; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE;

ADD ON THERAPY; ARTIFICIAL VENTILATION; BLOOD PRESSURE MONITORING; BRAIN DISEASE; CLINICAL TRIAL; CRITICALLY ILL PATIENT; DRUG HALF LIFE; DRUG MECHANISM; DRUG SUBSTITUTION; ELECTROCARDIOGRAM; ELECTROENCEPHALOGRAM; EPILEPTIC STATE; HUMAN; LIVER FAILURE; LOADING DRUG DOSE; MONOTHERAPY; MORTALITY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREATITIS; PARKINSONISM; PRIORITY JOURNAL; PROGNOSIS; RADIODIAGNOSIS; REVIEW; THROMBOCYTOPENIA;

ACUTE DISEASE; ANTICONVULSANTS; CRITICAL CARE; EPILEPSY; HUMANS; STATUS EPILEPTICUS;

EID: 44349157556     PISSN: 07338619     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ncl.2008.03.017     Document Type: Review

References (112)

1. Abou Khaled K.J., and Hirsch L.J. Advances in the management of seizures and status epilepticus in critically ill patients. Crit Care Clin 22 4 (2006) 637-659
2. DeLorenzo R.J., Pellock J.M., Towne A.R., et al. Epidemiology of status epilepticus. J Clin Neurophysiol 12 (1995) 316-325
3. Gastaut H. Classification of status epilepticus. Adv Neurol 34 (1983) 15-35
4. Bleck T.P. Convulsive disorders: status epilepticus. Clin Neuropharmacol 14 (1991) 191-198
5. Lowenstein D.H., Bleck T., and Macdonald R.L. It's time to revise the definition of status epilepticus. Epilepsia 40 (1999) 120-122
6. Treiman D.M., Meyers P.D., Walton N.Y., et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med 339 (1998) 792-798
7. Lowenstein D.H., and Alldredge B.K. Status epilepticus at an urban public hospital in the 1980s. Neurology 43 3 Pt 1 (1993) 483-488
8. Aminoff M.J., and Simon R.P. Status epilepticus: causes, clinical features and consequences in 98 patients. Am J Med 69 (1980) 657-666
9. Towne A.R., Waterhouse E.J., Boggs J.G., et al. Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology 54 (2000) 340-345
10. Agarwal P., Kumar N., Chandra R., et al. Randomized study of intravenous valproate and phenytoin in status epilepticus. Seizure 16 6 (2007) 527-532
11. Misra U.K., Kalita J., and Patel R. Sodium valproate vs phenytoin in status epilepticus: a pilot study. Neurology 67 2 (2006) 340-342
12. Koppel B.S., Hauser W.A., Politis C., et al. Seizures in the critically ill: the role of imipenem. Epilepsia 42 12 (2001) 1590-1593
13. Hirsch L.J., and Claassen J. The current state of treatment of status epilepticus. Curr Neurol Neurosci Rep 2 (2002) 345-356
14. Kaplan P.W. The clinical features, diagnosis, and prognosis of nonconvulsive status epilepticus. Neurologist 11 (2005) 348-361
15. DeLorenzo R.J., Waterhouse E.J., Towne A.R., et al. Persistent nonconvulsive status epilepticus after the control of convulsive status epilepticus. Epilepsia 39 (1998) 833-840
16. Jordan K. Nonconvulsive status epilepticus in acute brain injury. J Clin Neurophysiol 16 (1999) 332-340
17. Vespa P.M., Nuwer M.R., Nenov V., et al. Increased incidence and impact of nonconvulsive and convulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoring. J Neurosurg 91 (1999) 750-760
18. Claassen J., Mayer S.A., Kowalski R.G., et al. Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology 62 (2004) 1743-1748
19. Hesdorffer D.C., Logroscino G., Cascino G., et al. Incidence of status epilepticus in Rochester, Minnesota, 1965-1984. Neurology 50 (1998) 735-741
20. DeLorenzo R.J., Hauser W.A., Towne A.R., et al. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology 46 (1996) 1029-1035
21. DeLorenzo R.J., Towne A.R., Pellock J.M., et al. Status epilepticus in children, adults, and the elderly. Epilepsia 33 Suppl 4 (1992) S15-S25
22. Towne A.R., Pellock J.M., Ko D., et al. Determinants of mortality in status epilepticus. Epilepsia 35 (1994) 27-34
23. Koubeissi M., and Alshekhlee A. In-hospital mortality of generalized convulsive status epilepticus: a large US sample. Neurology 69 9 (2007) 886-893
24. Litt B., Wityk R.J., Hertz S.H., et al. Nonconvulsive status epilepticus in the critically ill elderly. Epilepsia 39 (1998) 1194-1202
25. Shneker B.F., and Fountain N.B. Assessment of acute morbidity and mortality in nonconvulsive status epilepticus. Neurology 61 (2003) 1066-1073
26. Lothman E.W., Bertram E.H., Bekenstein J.W., et al. Self-sustaining limbic status epilepticus induced by 'continuous' hippocampal stimulation: electrographic and behavioral characteristics. Epilepsy Res 3 (1989) 107-119
27. Krsek P., Mikulecká A., Druga R., et al. Long-term behavioral and morphological consequences of nonconvulsive status epilepticus in rats. Epilepsy Behav 5 2 (2004) 180-191
28. Sankar R., Shin D.H., and Wasterlain C.G. Serum neuron-specific enolase is a marker for neuronal damage following status epilepticus in the rat. Epilepsy Res 28 (1997) 129-136
29. DeGiorgio C.M., Correale J.D., Gott P.S., et al. Serum neuron-specific enolase in human status epilepticus. Neurology 45 (1995) 1134-1137
30. DeGiorgio C.M., Heck C.N., Rabinowicz A.L., et al. Serum neuron-specific enolase in the major subtypes of status epilepticus. Neurology 52 (1999) 746-749
31. DeGiorgio C.M., Gott P.S., Rabinowicz A.L., et al. Neuron-specific enolase, a marker of acute neuronal injury, is increased in complex partial status epilepticus. Epilepsia 37 (1996) 606-609
32. Rabinowicz A.L., Correale J.D., Bracht K.A., et al. Neuron-specific enolase is increased after nonconvulsive status epilepticus. Epilepsia 36 (1995) 475-479
33. Kim J.A., Chung J.I., Yoon P.H., et al. Transient MR signal changes in patients with generalized tonicoclonic seizure or status epilepticus: periictal diffusion-weighted imaging. AJNR Am J Neuroradiol 22 (2001) 1149-1160
34. Wieshmann U.C., Woermann F.G., Lemieux L., et al. Development of hippocampal atrophy: a serial magnetic resonance imaging study in a patient who developed epilepsy after generalized status epilepticus. Epilepsia 38 (1997) 1238-1241
35. Chan S., Chin S.S., Kartha K., et al. Reversible signal abnormalities in the hippocampus and neocortex after prolonged seizures. AJNR Am J Neuroradiol 17 (1996) 1725-1731
36. DeGiorgio C.M., Tomiyasu U., Gott P.S., et al. Hippocampal pyramidal cell loss in human status epilepticus. Epilepsia 33 (1992) 23-27
37. Fountain N.B., and Lothman E.W. Pathophysiology of status epilepticus. J Clin Neurophysiol 12 (1995) 326-342
38. Simon R.P. Physiologic consequences of status epilepticus. Epilepsia 26 Suppl 1 (1985) S58-S66
39. Meldrum B.S., Vigouroux R.A., and Brierley J.B. Systemic factors and epileptic brain damage: prolonged seizures in paralyzed, artificially ventilated baboons. Arch Neurol 29 (1973) 82-87
40. Boggs J.G., Painter J.A., and DeLorenzo R.J. Analysis of electrocardiographic changes in status epilepticus. Epilepsy Res 14 (1993) 87-94
41. Manno E.M., Pfeifer E.A., Cascino G.D., et al. Cardiac pathology in status epilepticus. Ann Neurol 58 (2005) 954-957
42. Chen D.K., So Y.T., and Fisher R.S. Use of serum prolactin in diagnosing epileptic seizures: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 65 (2005) 668-675
43. Barry E., and Hauser W.A. Pleocytosis after status epilepticus. Arch Neurol 51 (1994) 190-193
44. Mazarati A.M., Baldwin R.A., Sankar R., et al. Time-dependent decrease in the effectiveness of antiepileptic drugs during the course of self-sustaining status epilepticus. Brain Res 814 1-2 (1998) 179-185
45. Bleck T.P. Management approaches to prolonged seizures and status epilepticus. Epilepsia 40 Suppl 1 (1999) S59-S63
46. Leppik I.E., Derivan A.T., Homan R.W., et al. Double-blind study of lorazepam and diazepam in status epilepticus. JAMA 249 (1983) 1452-1454
47. Pang T., and Hirsch L.J. Treatment of convulsive and nonconvulsive status epilepticus. Curr Treat Options Neurol 7 (2005) 247-259
48. Bauer L.A. Interference of oral phenytoin absorption by continuous nasogastric feedings. Neurology 32 (1982) 570-572
49. Sander J.W., and Perucca E. Epilepsy and comorbidity: infections and antimicrobials usage in relation to epilepsy management. Acta Neurol Scand Suppl 180 (2003) 16-22
50. Czapinski P., and Terczynski A. [Intravenous valproic acid administration in status epilepticus]. Neurol Neurochir Pol 32 (1998) 11-22 [in Polish]
51. Giroud M., Gras D., Escousse A., et al. Use of injectable valproic acid in status epilepticus: a pilot study. Drug Invest 5 (1993) 154-159
52. Sinha S., and Naritoku D.K. Intravenous valproate is well tolerated in unstable patients with status epilepticus. Neurology 55 (2000) 722-724
53. Peters C.N., and Pohlmann-Eden B. Intravenous valproate as an innovative therapy in seizure emergency situations including status epilepticus-experience in 102 adult patients. Seizure 14 (2005) 164-169
54. Rossetti A.O., Logroscino G., and Bromfield E.B. Refractory status epilepticus: effect of treatment aggressiveness on prognosis. Arch Neurol 62 (2005) 1698-1702
55. Claassen J., Hirsch L.J., Emerson R.G., et al. Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review. Epilepsia 43 (2002) 146-153
56. Walker M.C., Smith S.J., and Shorvon S.D. The intensive care treatment of convulsive status epilepticus in the UK: results of a national survey and recommendations. Anaesthesia 50 (1995) 130-135
57. Naritoku D.K., and Sinha S. Prolongation of midazolam half-life after sustained infusion for status epilepticus. Neurology 54 (2000) 1366-1368
58. Vasile B., Rasulo F., Candiani A., et al. The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. Intensive Care Med 29 (2003) 1417-1425
59. Kumar M.A., Urrutia V.C., Thomas C.E., et al. The syndrome of irreversible acidosis after prolonged propofol infusion. Neurocrit Care 3 (2005) 257-259
60. Cremer O.L., Moons K.G., Bouman E.A., et al. Long-term propofol infusion and cardiac failure in adult head-injured patients. Lancet 357 (2001) 117-118
61. Cray S. Fat metabolism during propofol infusion. Br J Anaesth 82 (1999) 473
62. Rossetti A.O., Reichhart M.D., Schaller M.D., et al. Propofol treatment of refractory status epilepticus: a study of 31 episodes. Epilepsia 45 (2004) 757-763
63. Rossetti A.O., and Bromfield E.B. Levetiracetam in the treatment of status epilepticus in adults: a study of 13 episodes. Eur Neurol 54 (2005) 34-38
64. Rossetti A.O., and Bromfield E.B. Determinants of success in the use of oral levetiracetam in status epilepticus. Epilepsy Behav 8 (2006) 651-654
65. Knake S., Gruener J., Hatteme K., et al. Intravenous levetiracetam in the treatment of benzodiazepine-refractory status epilepticus. J Neurol Neurosurg Psychiatry 79 5 (2008) 588-589
66. Towne A.R., Garnett L.K., Waterhouse E.J., et al. The use of topiramate in refractory status epilepticus. Neurology 60 (2003) 332-334
67. Niebauer M., and Gruenthal M. Topiramate reduces neuronal injury after experimental status epilepticus. Brain Res 837 (1999) 263-269
68. Borris D.J., Bertram E.H., and Kapur J. Ketamine controls prolonged status epilepticus. Epilepsy Res 42 (2000) 117-122
69. Guler G., Erdogan F., Golgeli A., et al. Ketamine reduces lidocaine-induced seizures in mice. Int J Neurosci 115 (2005) 1239-1244
70. Irifune M., Sato T., Kamata Y., et al. Evidence for GABA(A) receptor agonistic properties of ketamine: convulsive and anesthetic behavioral models in mice. Anesth Analg 91 (2000) 230-236
71. Mewasingh L.D., Sekhara T., Aeby A., et al. Oral ketamine in paediatric non-convulsive status epilepticus. Seizure 12 (2003) 483-489
72. Ubogu E.E., Sagar S.M., Lerner A.J., et al. Ketamine for refractory status epilepticus: a case of possible ketamine-induced neurotoxicity. Epilepsy Behav 4 (2003) 70-75
73. Kofke W.A., Young R.S., Davis P., et al. Isoflurane for refractory status epilepticus: a clinical series. Anesthesiology 71 (1989) 653-659
74. Mirsattari S.M., Sharpe M.D., and Young G.B. Treatment of refractory status epilepticus with inhalational anesthetic agents isoflurane and desflurane. Arch Neurol 61 (2004) 1254-1259
75. Prasad A.N., Stafstrom C.F., and Holmes G.L. Alternative epilepsy therapies: the ketogenic diet, immunoglobulins, and steroids. Epilepsia 37 Suppl 1 (1996) S81-S95
76. Pascual J., Ciudad J., and Berciano J. Role of lidocaine (lignocaine) in managing status epilepticus. J Neurol Neurosurg Psychiatry 55 (1992) 49-51
77. Plum F.P.J. Diagnosis of stupor and coma (1984), Davis, Philadelphia
78. Ellis A.J., Wendon J.A., and Williams R. Subclinical seizure activity and prophylactic phenytoin infusion in acute liver failure: a controlled clinical trial. Hepatology 32 (2000) 536-541
79. Ficker D.M., Westmoreland B.F., and Sharbrough F.W. Epileptiform abnormalities in hepatic encephalopathy. J Clin Neurophysiol 14 (1997) 230-234
80. Eleftheriadis N., Fourla E., Eleftheriadis D., et al. Status epilepticus as a manifestation of hepatic encephalopathy. Acta Neurol Scand 107 (2003) 142-144
81. Chong D.J., and Hirsch L.J. Which EEG patterns warrant treatment in the critically ill? Reviewing the evidence for treatment of periodic epileptiform discharges and related patterns. J Clin Neurophysiol 22 (2005) 79-91
82. Fountain N.B., and Waldman W.A. Effects of benzodiazepines on triphasic waves: implications for nonconvulsive status epilepticus. J Clin Neurophysiol 18 (2001) 345-352
83. Brenner R.P. Is it status?. Epilepsia 43 Suppl 3 (2002) 103-113
84. Rodighiero V. Effects of liver disease on pharmacokinetics: an update. Clin Pharmacokinet 37 (1999) 399-431
85. Gibbs J.E., Walker M.C., and Cock H.R. Levetiracetam: antiepileptic properties and protective effects on mitochondrial dysfunction in experimental status epilepticus. Epilepsia 47 (2006) 469-478
86. Kudin A.P., Debska-Vielhaber G., Vielhaber S., et al. The mechanism of neuroprotection by topiramate in an animal model of epilepsy. Epilepsia 45 (2004) 1478-1487
87. Glenn C.M., Astley S.J., and Watkins S.L. Dialysis-associated seizures in children and adolescents. Pediatr Nephrol 6 (1992) 182-186
88. Bergen D.C., Ristanovic R., Gorelick P.B., et al. Seizures and renal failures. Int J Artif Organs 17 (1994) 247-251
89. Scorza F.A., Albuquerque M., Arida R.M., et al. Seizure occurrence in patients with chronic renal insufficiency in regular hemodialysis program. Arq Neuropsiquiatr 63 (2005) 757-760
90. Bechstein W.O. Neurotoxicity of calcineurin inhibitors: impact and clinical management. Transpl Int 13 (2000) 313-326
91. Wijdicks E.F., Wiesner R.H., and Krom R.A. Neurotoxicity in liver transplant recipients with cyclosporine immunosuppression. Neurology 45 (1995) 1962-1964
92. Adams D.H., Ponsford S., Gunson B., et al. Neurological complications following liver transplantation. Lancet 1 (1987) 949-951
93. Martinez A.J., Estol C., and Faris A.A. Neurologic complications of liver transplantation. Neurol Clin 6 (1988) 327-348
94. Jost L., Jost L., Nogues M., et al. [Neurological complications of renal transplant]. Medicina (B Aires) 60 (2000) 161-164 [in Spanish]
95. Veroux P., Veroux M., Puliatti C., et al. Tacrolimus-induced neurotoxicity in kidney transplant recipients. Transplant Proc 34 (2002) 3188-3190
96. McEnery P.T., Nathan J., Bates S.R., et al. Convulsions in children undergoing renal transplantation. J Pediatr 115 (1989) 532-536
97. Cemillan C.A., Alonso-Pulpon L., Burgos-Lazaro R., et al. [Neurological complications in a series of 205 orthotopic heart transplant patients]. Rev Neurol 38 (2004) 906-912 [in Spanish]
98. Grigg M.M., Costanzo-Nordin M.R., Celesia G.G., et al. The etiology of seizures after cardiac transplantation. Transplant Proc 20 Suppl 3 (1988) 937-944
99. Vaughn B.V., Ali I.I., Olivier K.N., et al. Seizures in lung transplant recipients. Epilepsia 37 (1996) 1175-1179
100. Wong M., Mallory Jr. G.B., Goldstein J., et al. Neurologic complications of pediatric lung transplantation. Neurology 53 (1999) 1542-1549
101. Snider S., Bashir R., and Bierman P. Neurologic complications after high-dose chemotherapy and autologous bone marrow transplantation for Hodgkin's disease. Neurology 44 (1994) 681-684
102. Furlong T.G., and Gallucci B.B. Pattern of occurrence and clinical presentation of neurological complications in bone marrow transplant patients. Cancer Nurs 17 (1994) 27-36
103. Antonini G., Ceschin V., Morino S., et al. Early neurologic complications following allogeneic bone marrow transplant for leukemia: a prospective study. Neurology 50 (1998) 1441-1445
104. Kiok M.C. Neurologic complications of pancreas transplants. Neurol Clin 6 (1988) 367-376
105. Wijdicks E.F., Plevak D.J., Wiesner R.H., et al. Causes and outcome of seizures in liver transplant recipients. Neurology 47 (1996) 1523-1525
106. Pandian J.D., Cascino G.D., So E.L., et al. Digital video-electroencephalographic monitoring in the neurological-neurosurgical intensive care unit: clinical features and outcome. Arch Neurol 61 (2004) 1090-1094
107. Rowland M., and Gupta S.K. Cyclosporin-phenytoin interaction: re-evaluation using metabolite data. Br J Clin Pharmacol 24 (1987) 329-334
108. Perez-Miralles F., Sanchez-Manso J.C., Almenar-Bonet L., et al. Incidence of and risk factors for neurologic complications after heart transplantation. Transplant Proc 37 (2005) 4067-4070
109. Malheiros S.M., Almeida D.R., Massaro A.R., et al. Neurologic complications after heart transplantation. Arq Neuropsiquiatr 60 (2002) 192-197
110. Shuman R.E., and Varelas P.N. Seizure-inducing drugs used for the critically ill. In: Varelas P.N. (Ed). Seizures in critical care: a guide to diagnosis and therapeutics (2005), Humana Press, Totowa (NJ) 261-290
111. Garcia P.A., and Alldredge B.K. Medication-associated seizures. In: Delanty N. (Ed). Seizures: medical causes and management (2001), Humana Press, Totowa (NJ) 147-165
112. Garcia P.A., and Alldredge B.K. Drug-induced seizures. Neurol Clin 12 (1994) 85-99