Which EEG patterns warrant treatment in the critically ill? Reviewing the evidence for treatment of periodic epileptiform discharges and related patterns

Journal of Clinical Neurophysiology

Volumn 22, Issue 2, 2005, Pages 79-91

  Chong, Derek J ^a   Hirsch, Lawrence J ^a,b  

^a NewYork Presbyterian Hospital   (United States)

^b NEUROLOGICAL INSTITUTE   (United States)

Author keywords

Critically ill; EEG; GPEDs; Intensive care unit; Nonconvulsive seizures; Nonconvulsive status epilepticus; PEDs; Periodic discharges; PLEDs; SIRPIDs

Indexed keywords

ADOLESCENT; ADULT; AGED; CHILD; CONVULSION; CRITICAL ILLNESS; ELECTROENCEPHALOGRAM; EPILEPTIC DISCHARGE; EVIDENCE BASED MEDICINE; HUMAN; MAJOR CLINICAL STUDY; NERVE CELL LESION; PATIENT MONITORING; PERIODICITY; REVIEW; SEIZURE; STATISTICAL MODEL; TREATMENT INDICATION;

CRITICAL ILLNESS; ELECTROENCEPHALOGRAPHY; HUMANS; PERIODICITY; SEIZURES;

EID: 16844371573     PISSN: 07360258     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WNP.0000158699.78529.AF     Document Type: Review

References (72)

1. Assal F, Papazyan JP, Slosman DO, Jallon P, Goerres GW. (2001) SPECT in periodic lateralized epileptiform discharges (PLEDs): a form of partial status epilepticus? Seizure 10:260-5.
2. Banerjea MC, Diener W, Kutschke G, Schneble HJ, Korinthenberg R, Sutor AH. (2002) Pro- and anticoagulatory factors under sodium valproate-therapy in children. Neuropediatrics 33:215-20.
3. Baykan B, Kinay D, Gokyigit A, Gurses C. (2000) Periodic lateralized epileptiform discharges: association with seizures. Seizure 9:402-6.
4. Bozkurt MF, Saygi S, Erbas B. (2002) SPECT in a patient with postictal PLEDs: is hyperperfusion evidence of electrical seizure? Clin Electroencephalogr 33:171-3.
5. Brenner RP. (2002) Is it status? Epilepsia 43 Suppl 3:103-13.
6. Brenner RP, Schaul N. (1990) Periodic EEG patterns: classification, clinical correlation, and pathophysiology. J Clin Neurophysiol 7:249-67.
7. Buttner T, Lack B, Jager M, Wunsche W, Kuhn W, Muller T, Przuntek H, Postert T. (1999) Serum levels of neuron-specific enolase and s-100 protein after single tonic-clonic seizures. J Neurol 246:459-61.
8. Camilo O, Goldstein LB. (2004) Seizures and epilepsy after ischemic stroke. Stroke 35:1769-75.
9. Chatrian G, Shaw C, Leffman H. (1964) The significance of periodic lateralized epileptiform discharges in EEG: an electrographic, clinicial and pathological study. Electroencephalogr Clin Neurophysiol 17:177-93.
10. Chen KS, Kuo MF, Wang HS, Huang SC. (2003) Periodic lateralized epileptiform discharges of pediatric patients in Taiwan. Pediatr Neurol 28:100-3.
11. Chu NS. (1980) Periodic lateralized epileptiform discharges with preexisting focal brain lesions. Role of alcohol withdrawal and anoxic encephalopathy. Arch Neurol 37:551-4.
12. Claassen J, Mayer SA, Kowalski RG, Emerson RG, Hirsch LJ. (2004) Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology 62:1743-8.
13. Cobb W, Hill D. (1950) Electroencephalogram in subacute progressive encephalitis. Brain 73:392-404.
14. de la Paz D, Brenner RP. (1981) Bilateral independent periodic lateralized epileptiform discharges. Clinical significance. Arch Neurol 38:713-5.
15. DeGiorgio CM, Correale JD, Gott PS, Ginsburg DL, Bracht KA, Smith T, Boutros R, Loskota WJ, Rabinowicz AL. (1995) Serum neuron-specific enolase in human status epilepticus. Neurology 45:1134-7.
16. DeGiorgio CM, Gott PS, Rabinowicz AL, Heck CN, Smith TD, Correale JD. (1996) Neuron-specific enolase, a marker of acute neuronal injury, is increased in complex partial status epilepticus. Epilepsia 37:606-9.
17. DeGiorgio CM, Heck CN, Rabinowicz AL, Gott PS, Smith T, Correale J. (1999) Serum neuron-specific enolase in the major subtypes of status epilepticus. Neurology 52:746-9.
18. Dunand AC, Jallon P. (2003) EEG-mediated diagnosis of an unusual presentation of SSPE. Clin Neurophysiol 114:737-9.
19. Fisch BJ. (1999) Fisch and Spehlmann's EEG primer, 3rd ed. Amsterdam: Elsevier.
20. Fountain NB, Waldman WA. (2001) Effects of benzodiazepines on triphasic waves: implications for nonconvulsive status epilepticus. J Clin Neurophysiol 18:345-52.
21. Fushimi M, Matsubuchi N, Sekine A, Shimizu T. (2003) Benign bilateral independent periodic lateralized epileptiform discharges. Acta Neurol Scand 108:55-9.
22. Garcia-Morales I, Garcia MT, Galan-Davila L, Gomez-Escalonilla C, Saiz-Diaz R, Martinez-Salio A, de la Pena P, Tejerina JA. (2002) Periodic lateralized epileptiform discharges: etiology, clinical aspects, seizures, and evolution in 130 patients. J Clin Neurophysiol 19:172-7.
23. Gascon GG. (2003) Randomized treatment study of inosiplex versus combined inosiplex and intraventricular interferon-alpha in subacute sclerosing panencephalitis (SSPE): international multicenter study. J Child Neurol 18:819-27.
24. Gidal B, Spencer N, Maly M, Pitterle M, Williams E, Collins M, Jones J. (1994) Valproate-mediated disturbances of hemostasis: relationship to dose and plasma concentration. Neurology 44:1418-22.
25. Gurer G, Yemisci M, Saygi S, Ciger A. (2004) Structural lesions in periodic lateralized epileptiform discharges (PLEDs). In, translator and editor Clin EEG Neurosci 35:88-93.
26. Handforth A, Cheng JT, Mandelkern MA, Treiman DM. (1994) Markedly increased mesiotemporal lobe metabolism in a case with PLEDs: further evidence that PLEDs are a manifestation of partial status epilepticus. Epilepsia 35:876-81.
27. Hartings JA, Williams AJ, Tortella FC. (2003) Occurrence of nonconvulsive seizures, periodic epileptiform discharges, and intermittent rhythmic delta activity in rat focal ischemia. Exp Neurol 179:139-49.
28. Hirsch LJ, Claassen J. (2002) The current state of treatment of status epilepticus. Curr Neurol Neurosci Rep 2:345-56.
29. Hirsch LJ, Claassen J, Mayer SA, Emerson RG. (2004) Stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs): a common EEG phenomenon in the critically ill. Epilepsia 45:109-23.
30. Husain AM, Mebust KA, Radtke RA. (1999) Generalized periodic epileptiform discharges: etiologies, relationship to status epilepticus, and prognosis. J Clin Neurophysiol 16:51-8.
31. Janati A, Chesser MZ, Husain MM. (1986) Periodic lateralized epileptiform discharges (PLEDs): a possible role for metabolic factors in pathogenesis. Clin Electroencephalogr 17:36-43.
32. Kaplan PW. (2000) No, some types of nonconvulsive status epilepticus cause little permanent neurologic sequelae (or: "the cure may be worse than the disease"). Neurophysiol Clin 30:377-82.
33. Kis B, Szupera Z, Mezei Z, Gecse A, Telegdy G, Vecsei L. (1999) Valproate treatment and platelet function: the role of arachidonate metabolites. Epilepsia 40:307-10.
34. Kleine TO, Benes L, Zofel P. (2003) Studies of the brain specificity of S100B and neuron-specific enolase (NSE) in blood serum of acute care patients. Brain Res Bull 61:265-79.
35. Kossoff EH, Bergey GK, Freeman JM, Vining EP. (2001) Levetiracetam psychosis in children with epilepsy. Epilepsia 42:1611-3.
36. Kuroiwa Y, Celesia GG. (1980) Clinical significance of periodic EEG patterns. Arch Neurol 37:15-20.
37. Litt B, Wityk RJ, Hertz SH, Mullen PD, Weiss H, Ryan DD, Henry TR. (1998) Nonconvulsive status epilepticus in the critically ill elderly. Epilepsia 39:1194-202.
38. Markand ON, Panszi JG. (1975) The electroencephalogram in subacute sclerosing panencephalitis. Arch Neurol 32:719-26.
39. Palmio J, Peltola J, Vuorinen P, Laine S, Suhonen J, Keranen T. (2001) Normal CSF neuron-specific enolase and S-100 protein levels in patients with recent non-complicated tonic-clonic seizures. J Neurol Sci 183:27-31.
40. Pandian JD, Cascino GD, So EL, Manno E, Fulgham JR. (2004) Digital video-electroencephalographic monitoring in the neurological-neurosurgical intensive care unit: clinical features and outcome. Arch Neurol 61:1090-4.
41. Pohlmann-Eden B, Hoch DB, Cochius JI, Chiappa KH. (1996) Periodic lateralized epileptiform discharges-a critical review. J Clin Neurophysiol 13:519-30.
42. Pohlmann-Eden B, Peters CN, Wennberg R, Dempfle CE. (2003) Valproate induces reversible factor XIII deficiency with risk of perioperative bleeding. Acta Neurol Scand 108:142-5.
43. Rabinowicz AL, Correale J, Boutras RB, Couldwell WT, Henderson CW, DeGiorgio CM. (1996) Neuron-specific enolase is increased after single seizures during inpatient video/EEG monitoring. Epilepsia 37:122-5.
44. Rabinowicz AL, Correale JD, Bracht KA, Smith TD, DeGiorgio CM. (1995) Neuron-specific enolase is increased after nonconvulsive status epilepticus. Epilepsia 36:475-9.
45. Raroque HG Jr, Gonzales PC, Jhaveri HS, Leroy RF, Allen EC. (1993a) Defining the role of structural lesions and metabolic abnormalities in periodic lateralized epileptiform discharges. Epilepsia 34:279-83.
46. Raroque HG Jr, Wagner W, Gonzales PC, Leroy RF, Kamaze D, Riela AR, Roach ES. (1993b) Reassessment of the clinical significance of periodic lateralized epileptiform discharges in pediatric patients. Epilepsia 34:275-8.
47. Reiher J, Rivest J, Grand'Maison F, Leduc CP. (1991) Periodic lateralized epileptiform discharges with transitional rhythmic discharges: association with seizures. Electroencephalogr Clin Neurophysiol 78:12-7.
48. Robinson LR, Micklesen PJ, Tirschwell DL, Lew HL. (2003) Predictive value of somatosensory evoked potentials for awakening from coma. Crit Care Med 31:960-7.
49. Sankar R, Shin DH, Wasterlain CG. (1997) Serum neuron-specific enolase is a marker for neuronal damage following status epilepticus in the rat. Epilepsy Res 28:129-36.
50. Schraeder PL, Singh N. (1980) Seizure disorders following periodic lateralized epileptiform discharges. Epilepsia 21:647-53.
51. Sheridan PH, Sato S. (1986) Triphasic waves of metabolic encephalopathy versus spike-wave stupor. J Neurol Neurosurg Psychiatry 49:108-9.
52. Shivji ZM, Al-Zahrani IS, Al-Said YA, Jan MM. (2003) Subacute sclerosing panencephalitis presenting with unilateral periodic myoclonic jerks. Can J Neurol Sci 30:384-7.
53. Silverman IE, Restrepo L, Mathews GC. (2002) Poststroke seizures. Arch Neurol 59:195-201.
54. Snodgrass SM, Tsuburaya K, Ajmone-Marsan C. (1989) Clinical significance of periodic lateralized epileptiform discharges: relationship with status epilepticus. J Clin Neurophysiol 6:159-72.
55. Striano S, De Falco FA, Zaccaria F, Fels A, Natale S, Vacca G. (1986) Paroxysmal lateralized epileptiform discharges (PLEDS). Clinical-EEG correlations in twenty cases. Acta Neurol (Napoli) 8:1-12.
56. Teich M, Longin E, Dempfle CE, Konig S. (2004) Factor XIII deficiency associated with valproate treatment. Epilepsia 45:187-9.
57. Terzano MG, Parrino L, Mazzucchi A, Moretti G. (1986) Confusional states with periodic lateralized epileptiform discharges (PLEDs): a peculiar epileptic syndrome in the elderly. Epilepsia 27:446-57.
58. Tomoda A, Nomura K, Shiraishi S, Miike T, Hamada A, Hosoya M. (2003) [Trial of intraventricular ribavirin and interferon-alpha combination therapy for subacute sclerosing panencephalitis (SSPE) in Japan]. No To Hattatsu 35:321-6.
59. Treiman DM. (1998) Clinical trials for status epilepticus. Adv Neurol 76:173-8.
60. Tumani H, Otto M, Gefeller O, Wiltfang J, Herrendorf G, Mogge S, Steinhoff BJ. (1999) Kinetics of serum neuron-specific enolase and prolactin in patients after single epileptic seizures. Epilepsia 40:713-8.
61. Vespa PM, O'Phelan K, Shah M, Mirabelli J, Starkman S, Kidwell C, Saver J, Nuwer MR, Frazee JG, McArthur DA, Martin NA. (2003) Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcome. Neurology 60:1441-6.
62. Walsh JM, Brenner RP. (1987) Periodic lateralized epileptiform discharges-long-term outcome in adults. Epilepsia 28:533-6.
63. Westmoreland BF, Klass DW, Sharbrough FW. (1986) Chronic periodic lateralized epileptiform discharges. Arch Neurol 43:494-6.
64. Williams AJ, Tortella FC, Lu XM, Moreton JE, Kartings JA. (2004) Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia. J Pharmacol Exp Ther 311:220-7.
65. Wulff CH. (1982) Subacute sclerosing panencephalitis: serial electroencephalographic studies. J Neurol Neurosurg Psychiatry 45:418-21.
66. Yemisci M, Gurer G, Saygi S, Ciger A. (2003) Generalised periodic epileptiform discharges: clinical features, neuroradiological evaluation and prognosis in 37 adult patients. Seizure 12:465-72.
67. Young GB. (2000) The EEG in coma. J Clin Neurophysiol 17:473-85.
68. Young GB, Jordan KG, Doig GS. (1996) An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology 47:83-9.
69. Young GB, Kreeft JH, McLachlan RS, Demelo J. (1999) EEG and clinical associations with mortality in comatose patients in a general intensive care unit. J Clin Neurophysiol 16:354-60.
70. Young GB, Wang JT, Connolly JF. (2004) Prognostic determination in anoxic-ischemic and traumatic encephalopathies. J Clin Neurophysiol 21:379-90.
71. Youroukos S, Lazopoulou D, Michelakou D, Karagianni J. (2003) Acute psychosis associated with levetiracetam. Epileptic Disord 5:117-9.
72. Zeidler M, Stewart GE, Barraclough CR, Bateman DE, Bates D, Burn DJ, Colchester AC, Durward W, Fletcher NA, Hawkins SA, Mackenzie JM, Will RG. (1997) New variant Creutzfeldt-Jakob disease: neurological features and diagnostic tests. Lancet 350:903-7.