Inhibitory effect of emodin on bleomycin-induced pulmonary fibrosis in mice

Clinical and Experimental Pharmacology and Physiology

Volumn 36, Issue 2, 2009, Pages 146-153

  Chen, Xiao Hong ^a,b   Sun, Ren Shan ^b   Hu, Jian Ming ^a   Mo, Zi Yao ^a   Yang, Zi Feng ^a   Jin, Guang Yao ^a   Guan, Wen Da ^a   Zhong, Nan Shan ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bleomycin; Emodin; Pulmonary fibrosis

Indexed keywords

BLEOMYCIN; CARBOXYMETHYLCELLULOSE; COLLAGEN; EMODIN; HYDROXYPROLINE; INTERLEUKIN 13; INTERLEUKIN 4; MESSENGER RNA; MYELOPEROXIDASE; PROCOLLAGEN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CHINESE HERB; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; FIBROBLAST; HISTOPATHOLOGY; LUNG FIBROSIS; LUNG LAVAGE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEADY STATE;

ANIMALS; BLEOMYCIN; BRONCHOALVEOLAR LAVAGE FLUID; CELL PROLIFERATION; COLLAGEN; CYTOKINES; DISEASE MODELS, ANIMAL; EMODIN; FIBROBLASTS; LUNG; MICE; MICE, INBRED C57BL; PEROXIDASE; PULMONARY FIBROSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 58849097124     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.05048.x     Document Type: Article

References (52)

1. Giri SN. Novel pharmacological approaches to manage interstitial lung fibrosis in the twenty-first century. Annu. Rev. Pharmacol. Toxicol. 2003 43 : 73 95.
2. Hagiwara SI, Ishii Y, Kitamura S. Aerosolized administration of N-acetylcysteine attenuates lung fibrosis induced by bleomycin in mice. Am. J. Respir. Crit. Care Med. 2000 162 : 225 31.
3. Pacanowski MA, Amsden GW. Interferon gamma-1b in the treatment of idiopathic pulmonary fibrosis. Ann. Pharmacother. 2005 39 : 1678 86.
4. Bouros D, Antoniou KM, Tzouvelekis A, Siafakas NM. Interferon-gamma 1b for the treatment of idiopathic pulmonary fibrosis. Expert Opin. Biol. Ther. 2006 6 : 1051 60.
5. Nakagome K, Dohi M, Okunishi K, Tanaka R, Miyazaki J, Yamamoto K. In vivo IL-10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF-beta in the lung. Thorax 2006 61 : 886 94.
6. Cutroneo KR, White SL, Phan SH, Ehrlich HP. Therapies for bleomycin induced lung fibrosis through regulation of TGF-beta1 induced collagen gene expression. J. Cell. Physiol. 2007 211 : 585 9.
7. Zheng T, Liu W, Oh SY et al. IL-13 receptor {alpha}2 selectively inhibits IL-13-induced responses in the murine lung. J. Immunol. 2008 180 : 522 9.
8. Jakubzick C, Choi ES, Joshi BH et al. Therapeutic attenuation of pulmonary fibrosis via targeting of IL-4 and IL-13-responsive cells. J. Immunol. 2003 171 : 2684 93.
9. Kuo YC, Tsai WJ, Meng HC, Chen WP, Yang LY, Lin CY. Immune reponses in human mesangial cells regulated by emodin from Polygonum hypoleucum Ohwi. Life Sci. 2001 68 : 1271 86.
10. Sato M, Maulik G, Bagchi D, Das DK. Myocardial protection by protykin, a novel extract of trans-resveratrol and emodin. Free Radic. Res. 2000 32 : 135 44.
11. Basu S, Ghosh A, Hazra B. Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn: Isolation of emodin and physcion as active antibacterial agents. Phytother. Res. 2005 19 : 888 94.
12. Huang HC, Lee CR, Chao PD, Chen CC, Chu SH. Vasorelaxant effect of emodin, an anthraquinone from a Chinese herb. Eur. J. Pharmacol. 1991 205 : 289 94.
13. Huang Q, Shen HM, Ong CN. Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway. Cell. Mol. Life Sci. 2005 62 : 1167 75.
14. Muto A, Hori M, Sasaki Y et al. Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor. Mol. Cancer Ther. 2007 6 : 987 94.
15. Lin CC, Chang CH, Yang JJ, Namba T, Hattori M. Hepatoprotective effects of emodin from Ventilago leiocarpa. J. Ethnopharmacol. 1996 52 : 107 11.
16. Imanishi Y, Maeda N, Otogawa K et al. Herb medicine Inchin-ko-to (TJ-135) regulates PDGF-BB-dependent signaling pathways of hepatic stellate cells in primary culture and attenuates development of liver fibrosis induced by thioacetamide administration in rats. J. Hepatol. 2004 41 : 242 50.
17. Wang CH, Gao ZQ, Ye B et al. Effect of emodin on pancreatic fibrosis in rats. World J. Gastroenterol. 2007 13 : 378 82.
18. Qu Y, Yao P, Li TQ. Effects of emodin on lung fibroblast proliferation and cell cycle in vitro. Sichuan Da Xue Xue Bao Yi Xue Ban 2004 35 : 74 6 (in Chinese with an English abstract).
19. Jules-Elysee K, White DA. Bleomycin-induced pulmonary toxicity. Clin. Chest Med. 1990 11 : 1 20.
20. Wang HD, Yamaya M, Okinaga S et al. Bilirubin ameliorates bleomycin-induced pulmonary fibrosis in rats. Am. J. Respir. Crit. Care Med. 2002 165 : 406 11.
21. Ashcroft T, Simpson JM, Timbrell V. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J. Clin. Pathol. 1988 41 : 467 70.
22. Shen Y, Zhao HL, Du J, et al. Feitai, a Chinese herbal medicine, reduces transforming growth factor-β1 and monocyte chemoattractant protein-1 expression in bleomycin-induced lung fibrosis in mice. Clin. Exp. Pharmacol. Physiol. 2005 32 : 1071 7.
23. Phan SH, Varani J, Smith D. Rat lung fibroblast collagen metabolism in bleomycin-induced pulmonary fibrosis. J. Clin. Invest. 1985 76 : 241 7.
24. Wu SH, Wu XH, Lu C, Dong L, Chen ZQ. Lipoxin A4 inhibits proliferation of human lung fibroblasts induced by connective tissue growth factor. Am. J. Respir. Cell. Mol. Biol. 2006 34 : 65 72.
25. Cortijo J, Cerdá-Nicolás M, Serrano A et al. Attenuation by oral N-acetylcysteine of bleomycin-induced lung injury in rats. Eur. Respir. J. 2001 17 : 1228 35.
26. Snider GL. Interstitial pulmonary fibrosis: Which cell is the culprit? Am. Rev. Respir. Dis. 1983 127 : 535 9.
27. Entzian P, Schlaak M, Seitzer U, Bufe A, Acil Y, Zabel P. Antiinflammatory and antifibrotic properties of colchicine: Implications for idiopathic pulmonary fibrosis. Lung 1997 175 : 41 51.
28. Filderman AE, Genovese LA, Lazo JS. Alternations in pulmonary protective enzymes following systemic bleomycin treatment in mice. Biochem. Pharmacol. 1988 37 : 1111 16.
29. El-Medanya A, Hagara HH, Moursib M, At Muhammed R, El-Rakhawy FI, El-Medany G. Attenuation of bleomycin-induced lung fibrosis in rats by mesna. Eur. J. Pharmacol. 2005 509 : 61 70.
30. Man X, Tu Z, Jia Y, Gong Y. Effects of emodin on nuclear factor-κB activation in pancreatic lesions in rats with acute pancreatitis. Chin. J. Dig. 2005 25 : 586 9 (in Chinese with an English abstract).
31. Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factorβ in human disease. N. Engl. J. Med. 2000 342 : 1350 8.
32. Pittet JF, Griffiths MJ, Geiser T et al. TGFβ1 is a critical mediator of acute lung injury. J. Clin. Invest. 2001 107 : 1537 44.
33. Otsuka M, Takahashi H, Shiratori M, Chiba H, Abe S. Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist. Thorax 2004 59 : 31 8.
34. Zhou XM, Zhang GC, Li JX, Hou J. Inhibitory effects of Hu-qi-yin on the bleomycin-induced pulmonary fibrosis in rats. J. Ethnopharmacol. 2007 111 : 255 64.
35. Yao HW, Zhou JP, Zhao MH, Lu Y. Losartan attenuates bleomycin-induced pulmonary fibrosis in rats. Respiration 2006 73 : 236 42.
36. Postlethwaite AE, Seyer JM. Fibroblast chemotaxis induction by human recombinant interleukin-4. Identification by synthetic peptide analysis of two chemotactic domains residing in amino acid sequences 70-88 and 89-122. J. Clin. Invest. 1991 87 : 2147 52.
37. Hogaboam CM, Bone-Larson CL, Lipinski S et al. Differential monocyte chemoattractant protein-1 and chemokine receptor 2 expression by murine lung fibroblasts derived from Th1- and Th2-type pulmonary granuloma models. J. Immunol. 1999 163 : 2193 201.
38. Makhluf HA, Stepniakowska J, Hoffman S, Smith E, LeRoy EC, Trojanowska M. IL-4 upregulates tenascin synthesis in scleroderma and healthy skin fibroblasts. J. Invest. Dermatol. 1996 107 : 856 9.
39. Sempowski GD, Beckmann MP, Derdak S, Phipps RP. Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors: Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis. J. Immunol. 1994 152 : 3606 14.
40. Zhu Z, Homer RJ, Wang Z et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 1999 103 : 779 88.
41. Lee CG, Homer RJ, Zhu Z et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factorβ1. J. Exp. Med. 2001 194 : 809 21.
42. Doucet C, Brouty-Boyé D, Pottin-Clemenceau C, Jasmin C, Canonica GW, Azzarone B. IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts. Int. Immunol. 1998 10 : 1421 33.
43. Oriente A, Fedarko NS, Pacocha SE, Huang SK, Lichtenstein LM, Essayan DM. Interleukin-13 modulates collagen homeostasis in human skin and keloid fibroblasts. J. Pharmacol. Exp. Ther. 2000 2 : 988 94.
44. Richter A, Puddicombe SM, Lordan JL et al. The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am. J. Respir. Cell. Mol. Biol. 2001 25 : 385 91.
45. Huang HC, Chang JH, Tung SF, Wu RT, Foegh ML, Chu SH. Immunosuppressive effect of emodin, a free radical generator. Eur. J. Pharmacol. 1992 211 : 359 64.
46. Kwak HJ, Park MJ, Park CM et al. Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation. Int. J. Cancer. 2006 118 : 2711 20.
47. Kaneshiro T, Morioka T, Inamine M et al. Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation. Eur. J. Pharmacol. 2006 553 : 46 53.
48. Wang X, Zou Y, Sun A et al. Emodin induces growth arrest and death of human vascular smooth muscle cells through reactive oxygen species and p53. J. Cardiovasc. Pharmacol. 2007 49 : 253 60.
49. Zhang HL, Tang ZY, Yang JX, Zhang Y, Li Y, Lin Y. Bi-directional regulation of emodin and quercetin on smooth muscle myosin of gizzard. FEBS Lett. 2006 580 : 469 73.
50. Fu ZY, Han JX, Huang HY. Effects of emodin on gene expression profile in small cell lung cancer NCI-H446 cells. Chin. Med. J. 2007 120 : 1710 15.
51. Lua MC, Hsieh MT, Wu CR et al. Ameliorating effect of emodin, a constitute of Polygonatum multiflorum, on cycloheximide-induced impairment of memory consolidation in rats. J. Ethnopharmacol. 2007 112 : 552 6.
52. Ma W, Zhang L, Zhang S, Xie Q. Protective effect of emodin on pulmonary injury in rats with acute necrotic pancreatitis. Guangdong Yi Xue Za Zhi 2005 23 : 504 9 (in Chinese with an English abstract).