Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist

Thorax

Volumn 59, Issue 1, 2004, Pages 31-38

  Otsuka, M ^a   Takahashi, H ^a   Shiratori, M ^a   Chiba, H ^a   Abe, S ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BLEOMYCIN; CANDESARTAN HEXETIL; DRINKING WATER; HYDROXYPROLINE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; CONTROLLED STUDY; EXPERIMENTAL MODEL; FIBROBLAST; IMMUNOBLOTTING; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; LUNG; LUNG ALVEOLUS CELL TYPE 2; LUNG FIBROSIS; LUNG HOMOGENATE; LUNG LAVAGE; MALE; MORPHOLOGY; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; RAT; RAT STRAIN; STATISTICAL SIGNIFICANCE; UPREGULATION;

ALBUMINS; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BENZIMIDAZOLES; BIPHENYL COMPOUNDS; BLEOMYCIN; BLOTTING, WESTERN; BRONCHOALVEOLAR LAVAGE FLUID; HYDROXYPROLINE; IMMUNOHISTOCHEMISTRY; MALE; PROTEINS; PULMONARY FIBROSIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; TETRAZOLES; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0346057802     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.2003.000893     Document Type: Article

References (34)

1. Murphy TJ, Takeuchi K, Alexander RW. Molecular cloning of AT1 angiotensin receptors. Am J Hypertens 1992;5:236-42S.
2. Burnier M, Burnner HR. Angiotensin II receptor antagonists. Lancet 2000;355:637-45.
3. Tanaka A, Matsumori A, Wang W, et al. An angiotensin II receptor antagonist reduces myocardial damage in an animal model of myocarditis. Circulation 1994;90:2051-5.
4. Kojima M, Shiojima I, Yamazaki T, et al. Angiotensin 2 receptor antagonist TCV-116 induced the regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathways of stretch-mediatea cardiomyocte hypertrophy in vivo. Circulation 1994;89:2204-11.
5. Sadoshima J, Izumo S. Molecular characterization of angiotensin 2-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of AT1 receptor subtype. Circ Res 1993;97:1952-9.
6. Schorb W, Booz GW, Dostal DE, et al. Angiotensin II is mitogenic in neonatal rat cardiac fibroblasts. Circ Res 1993;72:1245-54.
7. Villarreal FJ, Kim NN, Ungab GD, et al. Identification of functional angiotensin II receptors on rat cardiac fibroblasts. Circulation 1993;88:2849-61.
8. Yanagitani Y, Rakugi H, Okamura A, et al. Angiotensin 2 type 1 receptor-mediated peroxide production in human macrophage. Hypertension 1999;33:335-9.
9. Specks U, Martin WJ 2nd, Rohrbach MS. Bronchoalveolar lavage fluid angiotensin-converting enzyme in interstitial lung diseases. Am Rev Respir Dis 1990;141:117-23.
10. Song L, Wang D, Cui X, et al. Kinetic alterations of angiotensin II and nitric oxide in radiation pulmonary fibrosis. J Environ Pathol Toxicol Oncol 1998;17:141-50.
11. Morrell NW, Grieshaber SS, Danilov SM, et al. Developmental regulation of angiotensin converting enzyme and angiotensin type 1 receptor in the rat pulmonary circulation. Am J Respir Cell Mol Biol 1996;14:526-37.
12. Bullock GR, Steyaert I, Bilbe G, et al. Distribution of type-1 and type-2 angiotensin receptors in the normal human lung and in lungs from patients with chronic obstructive pulmonary disease. Histochem Cell Biol 2001;115:117-24.
13. Marshall R, McAnulty R, Lurent G. Angiotensin II is mitogenic for human lung fibroblasts via activation of the type 1 receptor. Am J Respir Crit Care Med 2000;161:1999-2004.
14. Wang R, Ibarra-Sunga O, Verlinski L, et al. Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor. Am J Physiol Lung Cell Mol Physiol 2000;279:L143-51.
15. Molteni A, Moulder JE, Cohen EF, et al. Control of radiation-induced pneumopothy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker. Int J Radiat Biol 2000;76:523-32.
16. Lee AA, Dillmann WH, McCulloch AD, et al. Angiotensin 2 stimulates the autocrine production of transforming growth factor-beta 1 in adult rat cardiac fibroblasts. J Mol Cell Cardiol 1995;27:2347-57.
17. Sun Y, Zhang JQ, Zhang J, et al. Angiotensin II, transforming growth factor-beta 1 and repair in the infarcted heart. J Mol Cell Cardiol 1998;30:1559-69.
18. Datta PK, Moulder JE, Fish BL, et al. TGF-beta 1 production in radiation nephropathy: role of angiotensin II. Int J Radit Biol 1999;75:473-9.
19. Khalil N, O'Connor RN, Unruh HW, et al. Increased production and Immunohistochemical localization of transforming growth factor-β in human pulmonary fibrosis. Am J Respir Cell Mol Biol 1991;5:155-62.
20. Khalil N, Bereznary O, Sporn M, et al. Macrophage production of transforming growth factor-β1 and fibroblast collagen synthesis in chronic pulmonary inflammation. J Exp Med 1989;170:727-37.
21. Broekelmann TJ, Limper AH, Colby TV, et al. Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci USA 1991;88:6642-6.
22. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350-4.
23. Kivirikko KI, Laitinen O, Prockop DJ. Modification of a specific assay for hydroxyproline in urine. Anal Biochem 1967;19:249-55.
24. Harrison-Bernard LM, El-Dahr SS, O'Leary DF, et al. Regulation of angiotensin II type 1 receptor mRNA and protein in angiotensin II-induced hypertension. Hypertension 1999;33:340-6.
25. Grafe M, Auch-Schwelk W, Zakrzewicz A, et al. Angiotensin II-induced leukocyte adhesion on human coronary endothelial cells is mediated by E-selection. Circ Res 1997;81:804-11.
26. Ito H, Takemori K, Suzuki T. Role of angiotensin II type 1 receptor in the leukocytes and endothelial cells of brain microvessels in the pathogenesis of hypertensive cerebral injury. J Hypertens 2001;19:591-7.
27. 2+ and the involvement of cyclic GMP. Br J Pharmacol 1997;121:643-8.
28. Farber HW, Center DM, Rounds S, et al. Components of the angiotensin system cause release of a neutrophil chemoattractant from cultured bovine and human endothelial cells. Eur Heart J 1990;11(Suppl B):100-7.
29. Hernandez-Presa MA, Bustos C, Ortego M, et al. ACE inhibitor quinapril reduces the arterial expression of NF-kappaB-dependent proinflammatory factors but not of collagen I in a rabbit model of atherosclerosis. Am J Pathol 1998;153:1825-37.
30. Carre PC, Mortenson RL, King TE Jr, et al. Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis. A potential mechanism for the recruitment and activation of neutrophils in lung fibrosis. J Clin Invest 1991;88:1802-10.
31. Stouffer GA, Owens GK. Angiotensin II-induced mitogenesis of spontaneously hypertensive rat-derived cultured smooth muscle cells is dependent on autocrine production of transforming growth factor-beta. Circ Res 1992;70:820-8.
32. McKay S, de Jongste JC, Saxena PR, et al. Angiotensin II induces hypertrophy of human airway smooth muscle cells: expression of transcription factors and transforming growth factor-beta1. Am J Respir Cell Mol Biol 1998;18:823-33.
33. Kagami S, Border WA, Miller DE, et al. Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells. J Clin Invest 1994;93:2431-7.
34. Thrall RS, McCormick JR, Jack RM, et al. Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin. Am J Pathol 1979;95:117-30.