Antioxidant properties of anesthetics: The biochemist, the surgeon and the anesthetist

Clinica Terapeutica

Volumn 159, Issue 6, 2008, Pages 463-469

  Li Volti, G ^a,b   Basile, F ^a   Murabito, P ^a,b   Galvano, F ^a   Di Giacomo, C ^a   Gazzolo, D ^a,c   Vadala S ^a   Azzolina, R ^a   D'Orazio, N ^d   Mufeed, H ^e   LVanella, ^a   Nicolosi, A ^a   Basile, G ^a   Biondi, A ^a  

^a GARIBALDI HOSPITAL   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c G GASLINI INSTITUTE   (Italy)

^d UNIVERSITY OF CHIETI   (Italy)

^e CAIRO UNIVERSITY   (Egypt)

Author keywords

Anesthetics; Heme oxygenase; Oxidative stress; Propofol

Indexed keywords

ALPHA TOCOPHEROL; ANESTHETIC AGENT; DESFLURANE; FENTANYL; ISOFLURANE; PROPOFOL; SEVOFLURANE;

ANTIOXIDANT ACTIVITY; ARTIFICIAL VENTILATION; CORONARY ARTERY BYPASS GRAFT; DNA DAMAGE; DRUG STRUCTURE; GENERAL ANESTHESIA; HUMAN; INTENSIVE CARE UNIT; LIPID PEROXIDATION; OXIDATIVE STRESS; REVIEW; SEDATION;

ADULT; ANESTHETICS, GENERAL; ANTIOXIDANTS; ASTROCYTES; CELLS, CULTURED; ENZYME INDUCTION; HEME OXYGENASE-1; HUMANS; HYPNOTICS AND SEDATIVES; IMMUNE TOLERANCE; INFLAMMATION; INFLAMMATION MEDIATORS; ISOFLURANE; LEUKOCYTES; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROPOFOL; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; VOLATILE ORGANIC COMPOUNDS;

EID: 58849096316     PISSN: 00099074     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (62)

1. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000; 408(6809):239-47
2. Behn C, Araneda OF, Llanos AJ, et al. Hypoxia-related lipid peroxidation: evidences, implications and approaches. Respir Physiol Neurobiol 2007; 158(2-3): 143-50
3. Moran LK, Gutteridge JM, Quinlan GJ. Thiols in cellular redox signaling and control. Curr Med Chem 2001; 8(7):763-72
4. Puig NR, Ferrero P, Bay ML, et al. Effects of sevoflurane general anesthesia: immunological studies in mice. Int Im- munopharmacol 2002; 2(1):95-104
5. Schilling T, Kozian A, Kretzschmar M, et al. Effects of propofol and desflurane anaesthesia on the alveolar inflammatory response to one-lung ventilation. Br J Anaesth 2007; 99(3):368-75
6. Kotani N, Takahashi S, Sessler DI, et al. Volatile anesthetics augment expression of proinflammatory cytokines in rat alveolar macrophages during mechanical ventilation. Anesthesiology 1999; 91(1): 187-97
7. Leduc LJ, Mitchell A. Intestinal ischemia after laparoscopic cholecystectomy. JSLS 2006; 10(2):236-8
8. O'Malley C, Cunningham AJ. Physiologic changes during laparoscopy Anesthesiol Clin North America 2001; 19(1): 1- 19
9. Andrei VE, Schein M, Wise L. Small bowel ischemia following laparoscopic cholecystectomy. Dig Surg 1999; 16(6):522-4
10. Aruoma OI. Antioxidant actions of plant foods: use of oxidative DNA damage as a tool for studying antioxidant efficacy. Free Radic Res 1999; 30(6):419-27
11. Buettner GR. The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. Arch Biochem Biophys 1993; 300(2):535-43
12. Przyklenk K, Kloner RA. "Reperfusion injury" by oxygen- derived free radicals? Effect of superoxide dismutase plus catalase, given at the time of reperfusion, on myocardial infarct size, contractile function, coronary microvasculature, and regional myocardial blood flow. Circ Res 1989; 64(l):86-96
13. Weir DL, Goodchild CS, Graham DI. Propofol: effects on indices of cerebral ischemia. J Neurosurg Anesthesiol 1989; l(3):284-9
14. Murphy PG, Myers DS, Davies MI, et al. The antioxidant potential of propofol (2,6-diisopropylphenol). Br J Anaesth 1992; 68(6):613-8
15. Green TR, Bennett SR, Nelson VM. Specificity and properties of propofol as an antioxidant free radical scavenger. Toxicol Appl Pharmacol 1994; 129(l):163-9
16. Sayin MM, Ozatamer O, Tasoz R, et al. Propofol attenuates myocardial lipid peroxidation during coronary artery bypass grafting surgery. Br J Anaesth 2002; 89(2):242-6
17. Manataki AD, Tselepis AD, et al. Lipid peroxidation and the use of emulsified propofol in laparoscopic surgery. Surg Endosc2001; 15(9):950-3
18. Stratford N, Murphy P. Antioxidant activity of propofol in blood from anaesthetized patients. Eur J Anaesthesiol 1998; 15(2): 158-60
19. Chen RM, Chen TG, Chen TL, et al. Anti-Inflammatory and Antioxidative Effects of Propofol on Lipopoly saccharide-Activated Macrophages. Ann N Y Acad Sci 2005; 1042:262-71
20. Hans P, Deby-Dupont G, Deby C, et al. Increase in antioxidant capacity of plasma during propofol anesthesia. J Neurosurg Anesthesiol 1997; 9(3):234-6
21. Sagara Y, Hendler S, Khoh-Reiter S, et al. Propofol hemisuccinate protects neuronal cells from oxidative injury. J Neurochem 1999; 73(6):2524-30
22. Agarwal R. Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents. Biochem Pharmacol 2000; 60(8):1051-9
23. Amakura Y, Tsutsumi T, Nakamura M, et al. Activation of the aryI hydrocarbon receptor by some vegetable constituents determined using in vitro reporter gene assay. Biol Pharm Bull 2003; 26(4):532-9
24. Moon SK, Cho GO, Jung SY, et al. Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase- 9. Biochem Biophys Res Commun 2003; 301(4): 1069-78
25. Scapagnini G, Foresti R, Calabrese V, et al. Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers. Mol Pharmacol 2002; 61(3):554-61
26. Acquaviva R, Campisi A, Murabito P, et al. Propofol attenuates peroxynitrite-mediated DNA damage and apoptosis in cultured astrocytes: an alternative protective mechanism. Anesthesiology 2004; 101(6): 1363-71
27. Acquaviva R, Campisi A, Raciti G, et al. Propofol inhibits caspase-3 in astroglial cells: role of heme oxygenase-1. Curr Neurovasc Res 2005; 2(2): 141-8
28. Eisenstein RS, Garcia-Mayol D, Pettingell W, et al. Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron. Proc Natl Acad Sci USA 1991; 88(3):688-92
29. Shibahara S, Yoshizawa M, Suzuki H, et al. Functional analysis of cDNAs for two types of human heme oxygenase and evidence for their separate regulation. J Biochem (Tokyo) 1993; 113(2):214-8
30. Abraham NG, Lin JH, Schwartzman ML, et al. The physiological significance of heme oxygenase. Int J Biochem 1988: 20(6):543-8
31. McCoubrey WK, Jr, Ewing JF, Maines MD. Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal. Arch Biochem Biophys 1992; 295(l):13-20
32. Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 2006; 86(2):583-650
33. Aldemir O, Celebi H, Cevik C, et al. The effects of propofol or halothane on free radical production after tourniquet induced ischaemia-reperfusion injury during knee arthroplasty. Acta Anaesthesiol Scand 2001; 45(10):1221-5
34. De La Cruz JP, Zanca A, Carmona JA, et al. The effect of propofol on oxidative stress in platelets from surgical patients. Anesth Analg 1999; 89(4): 1050-5
35. Zhang SH, Wang SY, Yao SL. Antioxidative effect of propofol during cardiopulmonary bypass in adults. Acta Pharmacol Sin 2004; 25(3):334-40
36. Yang LQ, Yu WF, Cao YF, et al. Potential inhibition of cytochrome P450 3A4 by propofol in human primary hepatocytes. World J Gastroenterol 2003; 9(9): 1959-62
37. Ogawa K, Tanaka S, Murray PA. Propofol potentiates pheny- lephrine-induced contraction via cyclooxygenase inhibition in pulmonary artery smooth muscle. Anesthesiology 2001; 94(5):833-9
38. Li Volti G, Seta F, Schwartzman ML, et al. Heme oxygenase attenuates angiotensin II-mediated increase in cyclooxygenase-2 activity in human femoral endothelial cells. Hypertension 2003; 41(3 Pt 2):715-9
39. Taille C, El Benna J, Lanone S, et al. Induction of Heme Oxygenase-1 Inhibits NAD(P)H Oxidase Activity by Down- regulating Cytochrome b558 Expression via the Reduction of Heme Availability. J Biol Chem 2004; 279(27):28681-8
40. Lavrovsky Y, Schwartzman ML, Abraham NG. Novel regulatory sites of the human heme oxygenase-1 promoter region. Biochem Biophys Res Commun 1993; 196(1):336-41
41. Zheng Z, Zhao H, Steinberg GK, et al. Cellular and molecular events underlying ischemia-induced neuronal apoptosis. Drug News Perspect 2003; 16(8):497-503
42. Fujimura M, Morita-Fujimura Y, et al. Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 1998; 18(11): 1239-47
43. Fujimura M, Morita-Fujimura Y, Kawase M, et al. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J Neurosci 1999; 19(9):3414-22
44. Green DR. Apoptotic pathways: the roads to ruin. Cell 1998; 94(6):695-8
45. Martin-Villalba A, Herr I, Jeremias I, et al. CD95 ligand (Fas-L/APO-lL) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons. J Neurosci 1999; 19(10):3809-17
46. Rosenbaum DM, Gupta G, D'Amore J, et al. Fas (CD95/ APO-1) plays a role in the pathophysiology of focal cerebral ischemia. J Neurosci Res 2000; 61 (6):686-92
47. Engelhard K, Werner C, Eberspacher E, et al. Sevoflurane and propofol influence the expression of apoptosis-regulating proteins after cerebral ischaemia and reperfusion in rats. Eur J Anaesthesiol 2004; 21(7):530-7
48. Raphael J, Rivo J, Gozal Y. Isoflurane-induced myocardial preconditioning is dependent on phosphatidylinositol-3-ki- nase/Akt signaling. Br J Anaesth 2005; 95(6):756 -63
49. Schlack W, Preckel B, Stunneck D, et al. Effects of halothane, enflurane, isoflurane, sevoflurane and desflurane on myocardial reperfusion injury in the isolated rat heart. Br J Anaesth 1998; 81(6):913-9
50. Preckel B, Schlack W, Comfere T, et al. Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo. Br J Anaesth 1998; 81(6):905-12
51. Preckel B, Schlack W, Thamer V. Enflurane and isoflurane, but not halothane, protect against myocardial reperfusion injury after cardioplegic arrest with HTK solution in the isolated rat heart. Anesth Analg 1998; 87(6):1221-7
52. Stadnicka A, Marinovic J, Ljubkovic M, et al. Volatile anesthetic-induced cardiac preconditioning. J Anesth 2007; 21(2):212-9.
53. Piriou V, Chiari P, Lhuillier F, et al. Pharmacological preconditioning: comparison of desflurane, sevoflurane, isoflurane and halothane in rabbit myocardium. Br J Anaesth 2002; 89(3):486-91
54. Riess ML, Eells JT, Kevin LG, et al. Attenuation of mitochondrial respiration by sevoflurane in isolated cardiac mitochondria is mediated in part by reactive oxygen species. Anesthesiology 2004; 100(3):498-505
55. Obal D, Preckel B, Scharbatke H, et al. One MAC of sevoflurane provides protection against reperfusion injury in the rat heart in vivo. Br J Anaesth 2001; 87(6):905-l 1
56. Seckin I, Sieck GC, Prakash YS. Volatile anaesthetic effects on Na+-Ca2+ exchange in rat cardiac myocytes. J Physiol 2001;532(Pt 1):91-104.
57. Minoda Y, Kharasch ED. Halothane-dependent lipid peroxidation in human liver microsomes is catalyzed by cytochrome P4502A6 (CYP2A6). Anesthesiology 2001; 95(2):509-14
58. Allaouchiche B, Debon R, Goudable J, et al. Oxidative stress status during exposure to propofol, sevoflurane and desflurane. Anesth Analg 2001; 93(4):981-5
59. Allaouchiche B, Duflo F, Debon R, et al. Influence of sepsis on minimum alveolar concentration of desflurane in a porcine model. Br J Anaesth 2001; 87(2):280-3
60. Sivaci R, Kahraman A, Serteser M, et al. Cytotoxic effects of volatile anesthetics with free radicals undergoing laparoscopic surgery. Clin Biochem 2006; 39(3):293-8
61. Schmidt R, Tritschler E, Hoetzel A, et al. Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/reperfusion injury. Ann Surg 2007; 245(6):931-42
62. Uchinami H, Yamamoto Y, Kume M, et al. Effect of heat shock preconditioning on NF-kappaB/I-kappaB pathway during I/R injury of the rat liver. Am J Physiol Gastrointest Liver Physiol 2002; 282(6):G962-71