CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits

Nature Neuroscience

Volumn 12, Issue 2, 2009, Pages 200-209

  Wallace, Deanna L ^a,f   Han, Ming Hu ^a   Graham, Danielle L ^a,g   Green, Thomas A ^a,h   Vialou, Vincent ^a,b   Ĩiguez, Sergio D ^c   Cao, Jun Li ^a   Kirk, Anne ^a   Chakravarty, Sumana ^a   Kumar, Arvind ^a   Krishnan, Vaishnav ^a   Neve, Rachael L ^d   Cooper, Don C ^a   Bolãos, Carlos A ^c   Barrot, Michel ^e   McClung, Colleen A ^a   Nestler, Eric J ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c FLORIDA STATE UNIVERSITY   (United States)

^d MCLEAN HOSPITAL   (United States)

^e Hopitaux Universitaires de Strasbourg   (France)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g MERCK RESEARCH LABORATORIES   (United States)

^h VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; POTASSIUM CHANNEL;

ACUTE DRUG ADMINISTRATION; ANHEDONIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BEHAVIOR CHANGE; CHRONIC DRUG ADMINISTRATION; DEPRESSION; ENZYME ACTIVITY; FEMALE; MALE; NERVE CELL EXCITABILITY; NONHUMAN; NUCLEUS ACCUMBENS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SOCIAL ISOLATION; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADRENERGIC UPTAKE INHIBITORS; AFFECTIVE SYMPTOMS; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; CREB-BINDING PROTEIN; FEMALE; GENE EXPRESSION PROFILING; IMIPRAMINE; LAC OPERON; MALE; MICE; MICE, TRANSGENIC; NUCLEUS ACCUMBENS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; SEXUAL BEHAVIOR, ANIMAL; SOCIAL ISOLATION;

EID: 58849095405     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2257     Document Type: Article

References (46)

1. Nestler, E.J. et al. Neurobiology of depression. Neuron 34, 13-25 (2002).
2. Barrot, M. et al. CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc. Natl. Acad. Sci. USA 99, 11435-11440 (2002).
3. Berton, O. et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311, 864-868 (2006).
4. Mendelson, S.D. & McEwen, B.S. Autoradiographic analyses of the effects of restraint-induced stress on 5-HT1A, 5-HT1C and 5-HT2 receptors in the dorsal hippocampus of male and female rats. Neuroendocrinology 54, 454-461 (1991).
5. Hall, F.S. Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences. Crit. Rev. Neurobiol. 12, 129-162 (1998).
6. Grippo, A.J., Cushing, B.S. & Carter, C.S. Depression-like behavior and stressor-induced neuroendocrine activation in female prairie voles exposed to chronic social isolation. Psychosom. Med. 69, 149-157 (2007).
7. Costello, J. & Kendrick, K. Grief and older people: the making or breaking of emotional bonds following partner loss in later life. J. Adv. Nurs. 32, 1374-1382 (2000).
8. Heinrich, L.M. & Gullone, E. The clinical significance of loneliness: a literature review. Clin. Psychol. Rev. 26, 695-718 (2006).
9. Ahmed, S.H., Stinus, L., Le Moal, M. & Cador, M. Social deprivation enhances the vulnerability of male Wistar rats to stressor- and amphetamine-induced behavioral sensitization. Psychopharmacology (Berl.) 117, 116-124 (1995).
10. Barrot, M. et al. Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens. Proc. Natl. Acad. Sci. USA 102, 8357-8362 (2005).
11. Ehlers, C.L., Walker, B.M., Pian, J.P., Roth, J.L. & Slawecki, C.J. Increased alcohol drinking in isolate-housed alcohol-preferring rats. Behav. Neurosci. 121, 111-119 (2007).
12. Deroche, V., Piazza, P.V., Le Moal, M. & Simon, H. Social isolation-induced enhancement of the psychomotor effects of morphine depends on corticosterone secretion. Brain Res. 640, 136-139 (1994).
13. Greco, A.M., Gambardella, P., Sticchi, R., D'Aponte, D. & De Franciscis, P. Chronic administration of imipramine antagonizes deranged circadian rhythm phases in individually housed rats. Physiol. Behav. 48, 67-72 (1990).
14. Stranahan, A.M., Khalil, D. & Gould, E. Social isolation delays the positive effects of running on adult neurogenesis. Nat. Neurosci. 9, 526-533 (2006).
15. Blendy, J.A. The role of CREB in depression and antidepressant treatment. Biol. Psychiatry 59, 1144-1150 (2006).
16. Newton, S.S. et al. Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect. J. Neurosci. 22, 10883-10890 (2002).
17. Pliakas, A.M. et al. Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. J. Neurosci. 21, 7397-7403 (2001).
18. Carlezon, W.A., Jr. et al. Regulation of cocaine reward by CREB. Science 282, 2272-2275 (1998).
19. Pandey, S.C. et al. CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction. Alcohol. Clin. Exp. Res. 29, 176-184 (2005).
20. Carlezon, W.A., Jr., Duman, R.S. & Nestler, E.J. The many faces of CREB. Trends Neurosci. 28, 436-445 (2005).
21. de Jong, T.R., Veening, J.G., Waldinger, M.D., Cools, A.R. & Olivier, B. Serotonin and the neurobiology of the ejaculatory threshold. Neurosci. Biobehav. Rev. 30, 893-907 (2006).
22. Ferguson, J.M. The effects of antidepressants on sexual functioning in depressed patients: a review. J. Clin. Psychiatry 62 Suppl 3: 22-34 (2001).
23. Rothschild, A.J. Sexual side effects of antidepressants. J. Clin. Psychiatry 61 Suppl11: 28-36 (2000).
24. Bolanos, C.A., Barrot, M., Berton, O., Wallace-Black, D. & Nestler, E.J. Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood. Biol. Psychiatry 54, 1317-1329 (2003).
25. Yirmiya, R. Endotoxin produces a depressive-like episode in rats. Brain Res. 711, 163-174 (1996).
26. Krishnan, V. et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131, 391-404 (2007).
27. Balfour, M.E., Yu, L. & Coolen, L.M. Sexual behavior and sex-associated environmental cues activate the mesolimbic system in male rats. Neuropsychopharmacology 29, 718-730 (2004).
28. Hull, E.M. & Dominguez, J.M. Sexual behavior in male rodents. Horm. Behav. 52, 45-55 (2007).
29. Meisel, R.L. & Mullins, A.J. Sexual experience in female rodents: cellular mechanisms and functional consequences. Brain Res. 1126, 56-65 (2006).
30. Conti, A.C. & Blendy, J.A. Regulation of antidepressant activity by cAMP response element binding proteins. Mol. Neurobiol. 30, 143-155 (2004).
31. Tsankova, N., Renthal, W., Kumar, A. & Nestler, E.J. Epigenetic regulation in psychiatric disorders. Nat. Rev. Neurosci. 8, 355-367 (2007).
32. Kumar, A. et al. Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48, 303-314 (2005).
33. McClung, C.A. & Nestler, E.J. Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat. Neurosci. 6, 1208-1215 (2003).
34. Dong, Y. et al. CREB modulates excitability of nucleus accumbens neurons. Nat. Neurosci. 9, 475-477 (2006).
35. Duman, R.S. & Monteggia, L.M. A neurotrophic model for stress-related mood disorders. Biol. Psychiatry 59, 1116-1127 (2006).
36. Berton, O. & Nestler, E.J. New approaches to antidepressant drug discovery: beyond monoamines. Nat. Rev. Neurosci. 7, 137-151 (2006).
37. Dulawa, S.C. & Hen, R. Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test. Neurosci. Biobehav. Rev. 29, 771-783 (2005).
38. Nibuya, M., Nestler, E.J. & Duman, R.S. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J. Neurosci. 16, 2365-2372 (1996).
39. Chen, A.C., Shirayama, Y., Shin, K.H., Neve, R.L. & Duman, R.S. Expression of the cAMP response element-binding protein (CREB) in hippocampus produces an antidepressant effect. Biol. Psychiatry 49, 753-762 (2001).
40. Pandey, S.C. The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction. Pharmacol. Ther. 104, 47-58 (2004).
41. Bell, T.J. et al. Cytoplasmic BK(Ca) channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons. Proc. Natl. Acad. Sci. USA 105, 1901-1906 (2008).
42. Salkoff, L., Butler, A., Ferreira, G., Santi, C. & Wei, A. High-conductance potassium channels of the SLO family. Nat. Rev. Neurosci. 7, 921-931 (2006).
43. Brown, E.S., Rush, A.J. & McEwen, B.S. Hippocampal remodeling and damage by corticosteroids: implications for mood disorders. Neuropsychopharmacology 21, 474-484 (1999).
44. Thome, J. et al. cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment. J. Neurosci. 20, 4030-4036 (2000).
45. Warner-Schmidt, J.L. & Duman, R.S. Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. Hippocampus 16, 239-249 (2006).
46. Impey, S. et al. Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. Nat. Neurosci. 1, 595-601 (1998).