CREB gene transcription factors: Role in molecular mechanisms of alcohol and drug addiction

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 2, 2005, Pages 176-184

  Pandey, Subhash C ^a   Chartoff, Elena H ^b   Carlezon Jr , William A ^b   Zou, Jian ^d   Zhang, Huaibo ^a   Kreibich, Arati S ^c   Blendy, Julie A ^c   Crews, Fulton T ^d  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b MCLEAN HOSPITAL   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol; Brain; Cocaine; CREB; Morphine; Stress

Indexed keywords

3 ALLYL 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; ADENYLATE CYCLASE; ALCOHOL; BRAIN DERIVED NEUROTROPHIC FACTOR; COCAINE; CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 2; DOPAMINE 1 RECEPTOR; DYNORPHIN; EARLY GROWTH RESPONSE FACTOR 1; G PROTEIN COUPLED RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NALOXONE; NEUROPEPTIDE Y; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN P53; SMAD PROTEIN; SOMATOMEDIN C; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR PAX5;

ALCOHOL WITHDRAWAL; ALCOHOLISM; ANHEDONIA; ANXIETY; AVERSION; CANADA; CONFERENCE PAPER; DRINKING BEHAVIOR; DRUG DEPENDENCE; DYSPHORIA; GENETIC TRANSCRIPTION; HUMAN; MESOLIMBIC DOPAMINERGIC SYSTEM; NERVE CELL PLASTICITY; NERVE DEGENERATION; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; PRIORITY JOURNAL; STRESS; VENTRAL TEGMENTUM;

ALCOHOLISM; ANIMALS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; HUMANS; SUBSTANCE-RELATED DISORDERS;

EID: 13844269034     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000153550.31168.1D     Document Type: Conference Paper

References (87)

1. Agartz I, Momenan R, Rawlings RR, Kerich MJ, Hommer DW (1999) Hippocampal volume in patients with alcohol dependence. Arch Gen Psychiatry 56:356-363.
2. Asher O, Cunningham TD, Yao L, Gordon AS, Diamond I (2002) Ethanol stimulates cAMP-responsive element (CRE)-mediated transcription via CRE-binding protein and cAMP-dependent protein kinase. J Pharmacol Exp Ther 301:66-70.
3. Barrot M, Olivier JD, Perrotti LI, DiLeone RJ, Berton O, Eisch AJ, Impey S, Storm DR, Neve RL, Yin JC, et al. (2002) CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci USA 99:11435-11440.
4. Bengochea O, Gonzalo LM (1990) Effect of chronic alcoholism on the human hippocampus. Histol Histopathol 5:349-357.
5. Bibb J, Chambless DL (1986) Alcohol use and abuse among diagnosed agoraphobics. Behav Res Ther 24:49-58.
6. Bilang-Bleuel A, Rech J, De Carli S, Holsboer F, Reul JM (2002) Forced swimming evokes a biphasic response in CREB phosphorylation in extrahypothalamic limbic and neocortical brain structures in the rat. Eur J Neurosci 15:1048-1060.
7. Bison S, Crews F (2003) Alcohol withdrawal increases neuropeptide Y immunoreactivity in rat brain. Alcohol Clin Exp Res 27:1173-1183.
8. Blendy JA, Kaestner KH, Schmid W, Gass P, Schutz G (1996) Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform. EMBO J 15:1098-1106.
9. Brandt J, Butters N, Ryan C, Bayog R (1983) Cognitive loss and recovery in long-term alcohol abusers. Arch Gen Psychiatry 40:435-442.
10. Carlen PL, Wortzman G, Holgate RC, Wilkinson DA, Rankin JC (1978) Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scans. Science 200:1076-1078.
11. Carlezon WA Jr, Thome J, Olson VG, Lane-Ladd SB, Brodkin ES, Hiroi N, Duman RS, Neve RL, Nestler EJ (1998) Regulation of cocaine reward by CREB. Science 282:2272-2275.
12. Chandler LJ, Harris RA, Crews FT (1998) Ethanol tolerance and synaptic plasticity. Trends Pharmacol Sci 19:491-495.
13. Chartoff EH, Mague SD, Carlezon WA Jr (2003a) Effect of dopamine D1 receptor agonists on precipitated opiate withdrawal-place aversions in rats. Soc Neurosci Abstracts 29:110.9.
14. Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA (2003b) Dopamine-dependent increase in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum. J Neurochem 87:107-118.
15. Childers SR (1991) Opioid receptor-coupled second messenger systems. Life Sci 48:1991-2003.
16. Cho S, Kim Y, Cruz MO, Park EM, Chu CK, Song GY, Joh TH (2001) Repression of proinflammatory cytokine and inducible nitric oxide synthase (NOS2) gene expression in activated microglia by N-acetyl-O-methyldopamine: protein kinase A-dependent mechanism. Glia 33:324-333.
17. Cloninger CR (1987) Neurogenetic adaptive mechanisms in alcoholism. Science 236:410-416.
18. Collins MA, Corse TD, Neafsey EJ (1996) Neuronal degeneration in rat cerebrocortical and olfactory regions during subchronic "binge" intoxication with ethanol: possible explanation for olfactory deficits in alcoholics. Alcohol Clin Exp Res 20:284-292.
19. Constantinescu A, Gordon AS, Diamond I (2002) cAMP-dependent protein kinase types I and II differentially regulate cAMP response element-mediated gene expression: implications for neuronal responses to ethanol. J Biol Chem 277:18810-18816.
20. Crews FT, Braun CJ (2003) Binge ethanol treatment causes greater brain damage in alcohol-preferring P rats than in alcohol-nonpreferring NP rats. Alcohol Clin Exp Res 27:1075-1082.
21. Crews FT, Braun CJ, Hoplight B, Switzer RC 3rd, Knapp DJ (2000) Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats. Alcohol Clin Exp Res 24:1712-1723.
22. Crews FT, Collins MA, Dlugos C, Littleton J, Wilkins L, Neafsey EJ, Pentney R, Snell LD, Tabakoff B, Zou J, Noronha A (2004) Alcohol-induced neurodegeneration: when, where, and why? Alcohol Clin Exp Res 28:350-364.
23. Crews FT, Miller MW, Ma W, Nixon K, Zawada WM, Zakhari S (2003) Neural stem cells and alcohol. Alcohol Clin Exp Res 27:324-335.
24. Crews FT, Morrow AL, Criswell H, Breese G (1996) Effects of ethanol on ion channels. Int Rev Neurobiol 39:283-367.
25. Dawson TM, Ginty DD (2002) CREB family transcription factors inhibit neuronal suicide. Nat Med 8:450-451.
26. Duman RS, Malberg J, Nakagawa S (2001) Regulation of adult neurogenesis by psychotropic drugs and stress. J Pharmacol Exp Ther 299: 401-407.
27. Eisch AJ (2002) Adult neurogenesis: implications for psychiatry. Prog Brain Res 138:315-342.
28. Erb S, Salmaso N, Rodaros D, Stewart J (2001) A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl) 158:360-365.
29. Harper C (1998) The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? J Neuropathol Exp Neurol 57:101-110.
30. Helzer JE, Pryzbeck TR (1988) The co-occurrence of alcoholism with other psychiatric disorders in the general population and its impact on treatment. J Stud Alcohol 49:219-224.
31. Hyman SE (1996) Addiction to cocaine and amphetamine. Neuron 16: 901-904.
32. Hummler E, Cole TJ, Blendy JA, Ganss R, Aguzzi A, Schmid W, Beermann F, Schutz G (1994) Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc Natl Acad Sci USA 91:5647-5651.
33. Hwang BH, Zhang J-K, Ehlers CL, Lumeng L, Li T-K (1999) Innate differences of neuropeptide Y (NPY) in hypothalamic nuclei and central nucleus of the amygdala between selectively bred rats with high and low alcohol preference. Alcohol Clin Exp Res 23:1023-1030.
34. Kano T, Suzuki Y, Shibuya M, Kiuchi K, Hagiwara M (1995) Cocaine-induced CREB phosphorylation and cFos expression are suppressed in Parkinsonism model mice. Neuroreport 6:2197-2200.
35. Konradi C, Cole RL, Heckers S, Hyman SE (1994) Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J Neurosci 14:5623-5634.
36. Koob GF (2003) Alcoholism: allostasis and beyond. Alcohol Clin Exp Res 27:232-243.
37. Koob GF, Maldonado R, Stinus L (1992) Neural substrates of opiate withdrawal. Trends Neurosci 15:186-191.
38. Knapp DJ, Crews FT (1999) Induction of cyclooxygenase-2 in brain during acute and chronic ethanol treatment and ethanol withdrawal. Alcohol Clin Exp Res 23:633-643.
39. Laakso MP, Vaurio O, Savolainen L, Repo E, Soininen H, Aronen HJ, Tiihonen J (2000) A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism. Behav Brain Res 109:177-186.
40. Lonze BE, Ginty DD (2002) Function and regulation of CREB family transcription factors in the nervous system. Neuron 35:605-623.
41. Mansour A, Fox CA, Burke S, Akil H, Watson SJ (1995) Immunohistochemical localization of the cloned mu opioid receptor in the rat CNS. J Chem Neuroanat 8:283-305.
42. Mayr B, Montminy M (2001) Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2:599-609.
43. Misra K, Pandey SC (2003) differences in basal levels of CREB and NPY in nucleus accumbens regions between C57BL/6 and DBA/2 mice differing in inborn alcohol drinking behavior. J Neurosci Res 74:967-975.
44. Nagakura A, Niimura M, Takeo S (2002) Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats. Br J Pharmacol 135:1783-1793.
45. Nakagawa S, Kim JE, Lee R, Chen J, Fujioka T, Malberg J, Tsuji S, Duman RS (2002a) Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus. J Neurosci 22:9868-9876.
46. Nakagawa S, Kim JE, Lee R, Malberg JE, Chen J, Steifen C, Zhang YJ, Nestler EJ, Duman RS (2002b) Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J Neurosci 22:3673-3682.
47. National Institute on Alcohol Abuse and Alcoholism (1993) Eighth Special Report to the Congress on Alcohol and Health. National Institute on Alcohol Abuse and Alcoholism, Bethesda (DHHS Publication No. ADM 281-91-003).
48. National Institute on Drug Abuse (1991) National Household Survey on Drug Abuse, Main Findings. National Institute on Drug Abuse, Rockville, MD (DHHS Publication No. ADM 92-1887)
49. Nestler EJ (2002) Common molecular and cellular substrates of addiction and memory. Neurobiol Learn Mem 78:637-647.
50. Nestler EJ, Aghajanian GK (1997) Molecular and cellular basis of addiction. Science 278:58-63.
51. Nixon K, Crews FT (2002) Binge ethanol exposure decreases neurogenesis in adult rat hippocampus. J Neurochem 83:1087-1093.
52. Nixon K, Crews FT (2004) Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol. J Neurosci 24:9714-9722.
53. Obernier JA, Bouldin TW, Crews FT (2002a) Binge ethanol exposure in adult rats causes necrotic cell death. Alcohol Clin Exp Res 26:547-557.
54. Obernier J, White A, Swartzwelder H, Crews F (2002b) Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats. Pharmacol Biochem Behav 72:521.
55. Pandey SC (2003) Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y gene. Trends Pharmacol 24:456-460.
56. Pandey SC (2004) The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction. Pharmacol Ther 104:47-58.
57. Pandey SC, Mittal N, Lumeng L, Li T-K (1999) Involvement of the cyclic AMP-responsive element binding protein gene transcription factor in genetic preference for alcohol drinking behavior. Alcohol Clin Exp Res 23:1425-1434.
58. Pandey SC, Roy A, Mittal N (2001) Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat cortex. J Pharmacol Exp Ther 296:857-868.
59. Pandey SC, Roy A, Zhang H (2003) The decreased phosphorylation of cyclic adenosine monophosphate (cAMP) response element binding (CREB) protein in the central amygdala acts as a molecular substrate for anxiety related to ethanol withdrawal in rats. Alcohol Clin Exp Res 27:396-409.
60. Pandey SC, Roy A, Zhang H, Tiejun Xu (2004) Partial deletion of the cAMP response element-binding protein gene promotes alcohol-drinking behaviors. J Neurosci 24:5022-5030.
61. Parsons OA (1993) Impaired neuropsychological cognitive functioning in sober alcoholics, in Alcohol-Induced Brain Damage (NIAAA Research Monograph No. 22) (Nixon SJ ed), pp 173-194. National Institutes of Health, Rockville, MD.
62. Petry NM (2001) A behavioral economic analysis of polydrug abuse in alcoholism: asymmetrical substitution of alcohol and cocaine. Drug Alcohol Depend 62:31-39.
63. Pierzchala K, Houdi AA, Van Loon GR (1987) Nicotine-induced alterations in brain regional concentrations of native and cryptic Met- and Leu-enkephalin. Peptides 8:1035-1043.
64. Pliakas AM, Carlson RR, Neve RL, Konradi C, Nestler EJ, Carlezon WA, Jr (2001) Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. J Neurosci 21:7397-7403.
65. Radel M, Goldman D (2001) Pharmacogenetics of alcohol response and alcoholism: the interplay of genes and environmental factors in thresholds for alcoholism. Drug Metab Dispos 29:489-494.
66. Riccio A, Ahn S, Davenport CM, Blendy JA, Ginty DD (1999) Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 286:2358-2361.
67. Sarnyai Z, Shaham Y, Heinrichs SC (2001) The role of corticotropin- releasing factor in drug addiction. Pharmacol Rev 53:209-243.
68. Schulteis G, Markou A, Gold LH, Stinus L, Koob GF (1994) Relative sensitivity to naloxone of multiple indices of opiate withdrawal: a quantitative dose-response analysis. J Pharmacol Exp Ther 271:1391-1398.
69. Shaywitz AJ, Greenberg ME (1999) CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68:821-861.
70. Silva AJ, Kogan JH, Frankland PW, Kida S (1998) CREB and memory. Annu Rev Neurosci 21:127-148.
71. Stanciu M, Radulovic J, Spiess J (2001) Phosphorylated cAMP response element binding protein in the mouse brain after fear conditioning: relationship to Fos production. Brain Res Mol Brain Res 94:15-24.
72. Sullivan EV, Marsh L, Mathalon DH, Lim KO, Pfefferbaum A (1995) Anterior hippocampal volume deficits in nonamnesic, aging chronic alcoholics. Alcohol Clin Exp Res 19:110-122.
73. Sullivan EV, Rosenbloom MJ, Pfefferbaum A (2000) Pattern of motor and cognitive deficits in detoxified alcoholic men. Alcohol Clin Exp Res 24:611-621.
74. Thome J, Gewirtz JC, Weijers HG, Weisbeck GA, Henn FA (2000) Genome polymorphism and alcoholism. Pharmacogenomics 1:63-71.
75. van Praag H, Christie BR, Sejnowski TJ, Gage FH (1999) Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci USA 96:13427-13431.
76. Walker DW, Barnes DE, Zornetzer SF, Hunter BE, Kubanis P (1980) Neuronal loss in hippocampus induced by prolonged ethanol consumption in rats. Science 209:711-713.
77. Walters CL, Blendy JA (2001) Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse. J Neurosci 21:9438-9444.
78. Wilson GT (1988) Alcohol and anxiety. Behav Res Ther 26:369-381.
79. Wise RA (1989) Opiate reward: sites and substrates. Neurosci Biobehav Rev 13:129-133.
80. Wise RA (1998) Drug-activation of brain reward pathways. Drug Alcohol Depend 51:13-22.
81. Yang X, Diehl AM, Wand GS (1996) Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding activity in rat cerebellum. J Pharmacol Exp Ther 278:338-346.
82. Yang X, Horn K, Baraban JM, Wand GS (1998a) Chronic ethanol administration decreases phosphorylation of cyclic AMP response element-binding protein in granule cells of rat cerebellum. J Neurochem 70:224-232.
83. Yang X, Horn K, Wand GS (1998b) Chronic ethanol exposure impairs phosphorylation of CREB and CRE-binding activity in rat striatum. Alcohol Clin Exp Res 22:382-390.
84. Zhang H, Pandey SC (2003) Effects of PKA modulation on the expression of neuropeptide Y in rat amygdaloid structures during ethanol withdrawal. Peptides 24:1397-1402.
85. Zhang HT, Crissman AM, Dorairaj NR, Chandler LJ, O'Donnell JM (2000) Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism. Neuropsychopharmacology 23:198-204.
86. Zou J, Crews F (2003) Ethanol modulation of nuclear transcription factors in rat brain slice cultures: implications for ethanol neurotoxicity. Alcohol Clin Exp Res 27:87A.
87. Zou J, Crews F (2004) Binge ethanol induced changes in transcription factors in rat brains identified by transignal protein/DNA array analysis. Alcohol Clin Exp Res 28:9A.