Serotonin and the neurobiology of the ejaculatory threshold

Neuroscience and Biobehavioral Reviews

Volumn 30, Issue 7, 2006, Pages 893-907

  de Jong, Trynke R ^a,b   Veening, Jan G ^a,b   Waldinger, Marcel D ^b,c   Cools, Alexander R ^a   Olivier, Berend ^b,d  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c LEYENBURG HOSPITAL   (Netherlands)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 HT; Ejaculation; Lateral hypothalamic area; Nucleus paragigantocellularis; Spinal cord; SSRIs

Indexed keywords

5 HYDROXYTRYPTOPHAN; ANTIDEPRESSANT AGENT; CITALOPRAM; FLUOXETINE; FLUVOXAMINE; PAROXETINE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SERTRALINE;

CENTRAL NERVOUS SYSTEM; EJACULATION; EJACULATION DISORDER; HUMAN; HYPOTHALAMUS; LUMBOSACRAL SPINE; NEUROANATOMY; NONHUMAN; PREMATURE EJACULATION; PRIORITY JOURNAL; PROTEIN FUNCTION; QUALITY OF LIFE; REVIEW; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; SPINAL CORD;

ANIMALS; EJACULATION; HUMANS; NEUROBIOLOGY; RECEPTORS, SEROTONIN; SEROTONIN;

EID: 33745949015     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2006.01.001     Document Type: Review

References (217)

1. Abramowski D., Rigo M., Duc D., Hoyer D., and Staufenbiel M. Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera. Neuropharmacology 34 (1995) 1635-1645
2. Ago Y., Nakamura S., Baba A., and Matsuda T. Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively in rat prefrontal cortex. Neuropsychopharmacology 30 (2005) 43-51
3. Ahlenius S., and Larsson K. Failure to antagonize the 8-hydroxy-2-di-n-propylamino)tetralin-induced facilitation of male rat sexual behavior by the administration of 5-HT receptor antagonists. European Journal of Pharmacology 99 (1984) 279-286
4. Ahlenius S., and Larsson K. Antagonism by lisuride and 8-OH-DPAT of 5-HTP-induced prolongation of the performance of male rat sexual behavior. European Journal of Pharmacology 110 (1985) 379-381
5. Ahlenius S., and Larsson K. Opposite effects of 5-methoxy-N,N-di-methyl-tryptamine and 5-hydroxytryptophan on male rat sexual behavior. Pharmacology Biochemistry and Behavior 38 (1991) 201-205
6. 1B receptors in the inhibition of male rat ejaculatory behavior produced by 5-HTP. Psychopharmacology (Berlin) 137 (1998) 374-382
7. 1A receptor antagonist WAY-100635 and citalopram on male rat ejaculatory behavior. European Journal of Pharmacology 379 (1999) 1-6
8. Ahlenius S., Eriksson H., Larsson K., Modigh K., and Sodersten P. Mating behavior in the male rat treated with p-chlorophenylalanine methyl ester alone and in combination with pargyline. Psychopharmacologia 20 (1971) 383-388
9. Ahlenius S., Heimann M., and Larsson K. Prolongation of the ejaculation latency in the male rat by thioridazine and chlorimipramine. Psychopharmacology (Berlin) 65 (1979) 137-140
10. Ahlenius S., Larsson K., and Svensson L. Further evidence for an inhibitory role of central 5-HT in male rat sexual behavior. Psychopharmacology (Berlin) 68 (1980) 217-220
11. Ahlenius S., Larsson K., Svensson L., Hjorth S., Carlsson A., Lindberg P., Wikstrom H., Sanchez D., Arvidsson L.E., Hacksell U., and Nilsson J.L. Effects of a new type of 5-HT receptor agonist on male rat sexual behavior. Pharmacology Biochemistry and Behavior 15 (1981) 785-792
12. Albinsson A., Andersson G., Andersson K., Vega-Matuszczyk J., and Larsson K. The effects of lesions in the mesencephalic raphe systems on male rat sexual behavior and locomotor activity. Behavioural Brain Research 80 (1996) 57-63
13. 1A receptor agonistic and 5-HT2 receptor antagonistic properties, on male rat sexual behavior. European Journal of Pharmacology 255 (1994) 131-137
14. 1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain. Brain Research 959 (2003) 58-67
15. Balfour M.E., Yu L., and Coolen L.M. Sexual behavior and sex-associated environmental cues activate the mesolimbic system in male rats. Neuropsychopharmacology 29 (2004) 718-730
16. Bancila M., Verge D., Rampin O., Backstrom J.R., Sanders-Bush E., McKenna K.E., Marson L., Calas A., and Giuliano F. 5-Hydroxytryptamine2C receptors on spinal neurons controlling penile erection in the rat. Neuroscience 92 (1999) 1523-1537
17. Bard J.A., Zgombick J., Adham N., Vaysse P., Branchek T.A., and Weinshank R.L. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. Journal of Biological Chemistry 268 (1993) 23422-23426
18. Barnes N.M., and Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 38 (1999) 1083-1152
19. Baum M.J., and Everitt B.J. Increased expression of c-fos in the medial preoptic area after mating in male rats: role of afferent inputs from the medial amygdala and midbrain central tegmental field. Neuroscience 50 (1992) 627-646
20. Bitran D., and Hull E.M. Pharmacological analysis of male rat sexual behavior. Neuroscience and Biobehavioural Reviews 11 (1987) 365-389
21. Blier P., Pineyro G., el Mansari M., Bergeron R., and de Montigny C. Role of somatodendritic 5-HT autoreceptors in modulating 5-HT neurotransmission. Annals of the New York Academy of Sciences 861 (1998) 204-216
22. Bosker F.J., Klompmakers A.A., and Westenberg H.G. Effects of single and repeated oral administration of fluvoxamine on extracellular serotonin in the median raphe nucleus and dorsal hippocampus of the rat. Neuropharmacology 34 (1995) 501-508
23. Bressler S.C., and Baum M.J. Sex comparison of neuronal Fos immunoreactivity in the rat vomeronasal projection circuit after chemosensory stimulation. Neuroscience 71 (1996) 1063-1072
24. Bymaster F.P., Zhang W., Carter P.A., Shaw J., Chernet E., Phebus L., Wong D.T., and Perry K.W. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berlin) 160 (2002) 353-361
25. Cantor J.M., Binik Y.M., and Pfaus J.G. Chronic fluoxetine inhibits sexual behavior in the male rat: reversal with oxytocin. Psychopharmacology (Berlin) 144 (1999) 355-362
26. Carro-Juarez M., and Rodriguez-Manzo G. Sensory and motor aspects of the coital reflex in the spinal male rat. Behavioural Brain Research 108 (2000) 97-103
27. Casu M.A., Pisu C., Lobina C., and Pani L. Immunocytochemical study of the forebrain serotonergic innervation in Sardinian alcohol-preferring rats. Psychopharmacology (Berlin) 172 (2004) 341-351
28. Chambille I., and Rampin O. AMPA glutamatergic receptor-immunoreactive subunits are expressed in lumbosacral neurons of the spinal cord and neurons of the dorsal root and pelvic ganglia controlling pelvic functions in the rat. Brain Research 933 (2002) 66-80
29. Chia S. Management of premature ejaculation-a comparison of treatment outcome in patients with and without erectile dysfunction. International Journal of Andrology 25 (2002) 301-305
30. Chung S.K., McVary K.T., and McKenna K.E. Sexual reflexes in male and female rats. Neuroscience Letters 94 (1988) 343-348
31. 1B receptor: behavioral implications. Psychopharmacology Bulletin 35 (2001) 170-185
32. Clement P., Bernabe J., Kia H.K., Alexandre L., and Giuliano F. D2-like receptors mediate the expulsion phase of ejaculation elicited by 8-hydroxy-2-(Di-N-propylamino)tetralin (8-Oh-Dpat) in rats. Journal of Pharmacology and Experimental Therapeutics 316 (2005) 830-834
33. 2C receptor protein in the rat CNS. Neuropharmacology 39 (2000) 123-132
34. 1A receptor immunoreactivity in hypothalamic neurons involved in body weight control. Neuroreport 13 (2002) 945-951
35. Coolen L.M., Peters H.J., and Veening J.G. Fos immunoreactivity in the rat brain following consummatory elements of sexual behavior: a sex comparison. Brain Research 738 (1996) 67-82
36. 1A agonist 8-OH-DPAT. Physiology & Behavior 62 (1997) 881-891
37. Coolen L.M., Peters H.J., and Veening J.G. Distribution of Fos immunoreactivity following mating versus anogenital investigation in the male rat brain. Neuroscience 77 (1997) 1151-1161
38. Coolen L.M., Peters H.J., and Veening J.G. Anatomical interrelationships of the medial preoptic area and other brain regions activated following male sexual behavior: a combined fos and tract-tracing study. Journal of Comparative Neurology 397 (1998) 421-435
39. Coolen L.M., Veening J.G., Petersen D.W., and Shipley M.T. Parvocellular subparafascicular thalamic nucleus in the rat: anatomical and functional compartmentalization. Journal of Comparative Neurology 463 (2003) 117-131
40. Coolen L.M., Veening J.G., Wells A.B., and Shipley M.T. Afferent connections of the parvocellular subparafascicular thalamic nucleus in the rat: evidence for functional subdivisions. Journal of Comparative Neurology 463 (2003) 132-156
41. 1B Receptors (2004), Society for Neuroscience, Online Abstract Viewer, Program Nr 998.1, Washington, DC
42. Coolen L.M., Allard J., Truitt W.A., and McKenna K.E. Central regulation of ejaculation. Physiology & Behavior 83 (2004) 203-215
43. Dahlof L.G., and Larsson K. PCPA potentiates the effects of specific copulatory experience on the sexual behavior of the pudendectomized male rat. Pharmacology Biochemistry and Behavior 11 (1979) 701-704
44. de Jong T.R., Pattij T., Veening J.G., Dederen P.J., Waldinger M.D., Cools A.R., and Olivier B. Citalopram combined with WAY 100635 inhibits ejaculation and ejaculation-related Fos immunoreactivity. European Journal of Pharmacology 509 (2005) 49-59
45. de Jong T.R., Pattij T., Veening J.G., Waldinger M.D., Cools A.R., and Olivier B. Effects of chronic selective serotonin reuptake inhibitors on 8-OH-DPAT-induced facilitation of ejaculation in rats: comparison of fluvoxamine and paroxetine. Psychopharmacology (Berlin) 179 (2005) 509-515
46. Denys D., Klompmakers A.A., and Westenberg H.G. Synergistic dopamine increase in the rat prefrontal cortex with the combination of quetiapine and fluvoxamine. Psychopharmacology (Berlin) 176 (2004) 195-203
47. Dominguez J., Riolo J.V., Xu Z., and Hull E.M. Regulation by the medial amygdala of copulation and medial preoptic dopamine release. Journal of Neuroscience 21 (2001) 349-355
48. Dornan W.A., and Malsbury C.W. Peptidergic control of male rat sexual behavior: the effects of intracerebral injections of substance P and cholecystokinin. Physiology & Behavior 46 (1989) 547-556
49. Drago F., Busa L., Benelli A., and Bertolini A. Acute low doses of melatonin stimulate rat sex behavior: the role of serotonin neurotransmission. European Journal of Pharmacology 385 (1999) 1-6
50. Duran I.D., Rojas-Piloni J.G., and Cueva-Rolon R. Facilitation and inhibition of the urethrogenital reflex in spinal cord-transected rats. Brain Research 775 (1997) 1-10
51. Duran I., Gil L., and Cueva-Rolon R. Masculine copulatory behavior is facilitated by intrathecally administered muscarine. Experimental Brain Research 134 (2000) 490-496
52. 1A receptors in rat brain. Neuropharmacology 44 (2003) 93-101
53. Felton T.M., Kang T.B., Hjorth S., and Auerbach S.B. Effects of selective serotonin and serotonin/noradrenaline reuptake inhibitors on extracellular serotonin in rat diencephalon and frontal cortex. Naunyn Schmiedebergs Archives of Pharmacology 367 (2003) 297-305
54. 1B agonists on masculine sexual behaviour: physiological and pharmacological implications. Journal of Neural Transmission-General Section 85 (1991) 95-107
55. 1B receptors. Pharmacology Biochemistry and Behavior 42 (1992) 529-533
56. Fernandez-Guasti A., and Rodriguez-Manzo G. 8-OH-DPAT and male rat sexual behavior: partial blockade by noradrenergic lesion and sexual exhaustion. Pharmacology Biochemistry and Behavior 56 (1997) 111-116
57. Fernandez-Guasti A., Hansen S., Archer T., and Jonsson G. Noradrenaline-serotonin interactions in the control of sexual behavior in the male rat: DSP4-induced noradrenaline depletion antagonizes the facilitatory effect of serotonin receptor agonists, 5-MeODMT and lisuride. Brain Research 377 (1986) 112-118
58. 1B receptor agonists on rat masculine sexual behaviour. Pharmacology Biochemistry and Behavior 34 (1989) 811-816
59. 1B receptors in brain regions and its effects on male rat sexual behaviour. European Journal of Pharmacology 210 (1992) 121-129
60. 1B receptors in brain regions and its effects on male rat sexual behaviour. European Journal of Pharmacology 210 (1992) 121-129
61. Fonseca M.I., Ni Y.G., Dunning D.D., and Miledi R. Distribution of serotonin 2A, 2C and 3 receptor mRNA in spinal cord and medulla oblongata. Brain Research Molecular Brain Research 89 (2001) 11-19
62. Foreman M.M., Hall J.L., and Love R.L. The role of the 5-HT2 receptor in the regulation of sexual performance of male rats. Life Sciences 45 (1989) 1263-1270
63. Foreman M.M., Hall J.L., and Love R.L. Effects of fenfluramine and para-chloroamphetamine on sexual behavior of male rats. Psychopharmacology (Berlin) 107 (1992) 327-330
64. Gardier A.M., Trillat A.C., Malagie I., and Jacquot C. 8-OH-DPAT attenuates the dexfenfluramine-induced increase in extracellular serotonin: an in vivo dialysis study. European Journal of Pharmacology 265 (1994) 107-110
65. Gartside S.E., Cowen P.J., and Sharp T. Effect of 5-hydroxy-l-tryptophan on the release of 5-HT in rat hypothalamus in vivo as measured by microdialysis. Neuropharmacology 31 (1992) 9-14
66. Gerendai I., Toth I.E., Kocsis K., Boldogkoi Z., Rusvai M., and Halasz B. Identification of CNS neurons involved in the innervation of the epididymis: a viral transneuronal tracing study. Autonomic Neuroscience 92 (2001) 1-10
67. Gessa G.L., and Tagliamonte A. Role of brain monoamines in male sexual behavior. Life Sciences 14 (1974) 425-436
68. Gobert A., Rivet J.M., Audinot V., Newman-Tancredi A., Cistarelli L., and Millan M.J. Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release. Neuroscience 84 (1998) 413-429
69. Gottsch M.L., Clifton D.K., and Steiner R.A. Galanin-like peptide as a link in the integration of metabolism and reproduction. Trends in Endocrinology and Metabolism 15 (2004) 215-221
70. Greco B., Edwards D.A., Michael R.P., and Clancy A.N. Androgen receptor immunoreactivity and mating-induced Fos expression in forebrain and midbrain structures in the male rat. Neuroscience 75 (1996) 161-171
71. Gregorian R.S., Golden K.A., Bahce A., Goodman C., Kwong W.J., and Khan Z.M. Antidepressant-induced sexual dysfunction. Annals of the Pharmacotherapy 36 (2002) 1577-1589
72. Haensel S.M., and Slob A.K. Flesinoxan: a prosexual drug for male rats. European Journal of Pharmacology 330 (1997) 1-9
73. 1A receptor-induced inhibition of 5-HT neuronal activity in the rat. British Journal of Pharmacology 126 (1999) 1741-1750
74. Hajos-Korcsok E., McTavish S.F., and Sharp T. Effect of a selective 5-hydroxytryptamine reuptake inhibitor on brain extracellular noradrenaline: microdialysis studies using paroxetine. European Journal of Pharmacology 407 (2000) 101-107
75. Hansen S., Kohler C., Goldstein M., and Steinbusch H.V. Effects of ibotenic acid-induced neuronal degeneration in the medial preoptic area and the lateral hypothalamic area on sexual behavior in the male rat. Brain Research 239 (1982) 213-232
76. Hartmann U., and Waldinger M.D. Ejaculatory disorders. World Journal of Urology 23 (2005) 67
77. Heeb M.M., and Yahr P. Anatomical and functional connections among cell groups in the gerbil brain that are activated with ejaculation. Journal of Comparative Neurology 439 (2001) 248-258
78. Helke C.J., Capuano S., Tran N., and Zhuo H. Immunocytochemical studies of the 5-HT(1A) receptor in ventral medullaryneurons that project to the intermediolateral cell column and contain serotonin or tyrosine hydroxylase immunoreactivity. Journal of Comparative Neurology 379 (1997) 261-270
79. 1A receptor function in brain following agonist or antidepressant administration. Life Sciences 72 (2003) 1665-1682
80. Hervas I., and Artigas F. Effect of fluoxetine on extracellular 5-hydroxytryptamine in rat brain. Role of 5-HT autoreceptors. European Journal of Pharmacology 358 (1998) 9-18
81. 1B receptor agonists 8-OH-DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD-299 and NAS-181. British Journal of Pharmacology 125 (1998) 1733-1743
82. Hillegaart V., Ahlenius S., and Larsson K. Effects of local application of 5-HT into the median and dorsal raphe nuclei on male rat sexual and motor behavior. Behavioural Brain Research 33 (1989) 279-286
83. Hillegaart V., Ahlenius S., and Larsson K. Region-selective inhibition of male rat sexual behavior and motor performance by localized forebrain 5-HT injections: a comparison with effects produced by 8-OH-DPAT. Behavioural Brain Research 42 (1991) 169-180
84. 1A receptor agonist 8-OH-DPAT on the release of 5-HT in dorsal and median raphe-innervated rat brain regions as measured by in vivo microdialysis. Life Sciences 48 (1991) 1779-1786
85. Hokfelt T., Arvidsson U., Cullheim S., Millhorn D., Nicholas A.P., Pieribone V., Seroogy K., and Ulfhake B. Multiple messengers in descending serotonin neurons: localization and functional implications. Journal of Chemical Neuroanatomy 18 (2000) 75-86
86. Hughes Z.A., Starr K.R., Langmead C.J., Hill M., Bartoszyk G.D., Hagan J.J., Middlemiss D.N., and Dawson L.A. Neurochemical evaluation of the novel 5-HT(1A) receptor partial agonist/serotonin reuptake inhibitor, vilazodone. European Journal of Pharmacology 510 (2005) 49-57
87. Hull E.M., Muschamp J.W., and Sato S. Dopamine and serotonin: influences on male sexual behavior. Physiology & Behavior 83 (2004) 291-307
88. Humphries C.R., Paxinos G., and O'Brien M. Mechanisms of PCA-induced hypothermia, ejaculation, salivation and irritability in rats. Pharmacology Biochemistry and Behavior 15 (1981) 197-200
89. Invernizzi R., Bramante M., and Samanin R. Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram. Brain Research 696 (1995) 62-66
90. 1A receptors in the effects of acute chronic fluoxetine on extracellular serotonin in the frontal cortex. Pharmacology Biochemistry and Behavior 54 (1996) 143-147
91. Kara H., Aydin S., Yucel M., Agargun M.Y., Odabas O., and Yilmaz Y. The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind placebo controlled study. Journal of Urology 156 (1996) 1631-1632
92. Kia H.K., Miquel M.C., Brisorgueil M.J., Daval G., Riad M., El Mestikawy S., Hamon M., and Verge D. Immunocytochemical localization of serotonin1A receptors in the rat central nervous system. Journal of Comparative Neurology 365 (1996) 289-305
93. Kim S.C., and Seo K.K. Efficacy and safety of fluoxetine, sertraline and clomipramine in patients with premature ejaculation: a double-blind, placebo controlled study. Journal of Urology 159 (1998) 425-427
94. Kimura Y., Kisaki N., Sakurada S., and Tadano T. On the brain monoaminergic systems relatint to ejaculation. II. Brain serotonin and ejaculation. Andrologia 9 (1977) 50-54
95. Kimura Y., Miyamoto A., Urano S., Yonezawa A., Tadano T., and Kisara K. The spinal monoaminergic systems relating to ejaculation. II. Ejaculation and serotonin. Andrologia 15 (1983) 222-227
96. Kippin T.E., Sotiropoulos V., Badih J., and Pfaus J.G. Opposing roles of the nucleus accumbens and anterior lateral hypothalamic area in the control of sexual behaviour in the male rat. European Journal of Neuroscience 19 (2004) 698-704
97. Klint T., and Larsson K. Clozapine acts as a 5-HT2 antagonist by attenuating DOI-induced inhibition of male rat sexual behaviour. Psychopharmacology (Berlin) 119 (1995) 291-294
98. Klint T., Dahlgren I.L., and Larsson K. The selective 5-HT2 receptor antagonist amperozide attenuates 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane-induced inhibition of male rat sexual behavior. European Journal of Pharmacology 212 (1992) 241-246
99. Kondo Y., and Yamanouchi K. The possible involvement of the nonstrial pathway of the amygdala in neural control of sexual behavior in male rats. Brain Research Bulletin 38 (1995) 37-40
100. Larsen P.J., Hay-Schmidt A., Vrang N., and Mikkelsen J.D. Origin of projections from the midbrain raphe nuclei to the hypothalamic paraventricular nucleus in the rat: a combined retrograde and anterograde tracing study. Neuroscience 70 (1996) 963-988
101. Larsson K., and Ahlenius S. Brain and sexual behavior. Annals of the New York Academy of Science 877 (1999) 292-308
102. 1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn Schmiedebergs Archives of Pharmacology 352 (1995) 141-148
103. 1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology 39 (2000) 110-122
104. Lee R.L., Smith E.R., Mas M., and Davidson J.M. Effects of intrathecal administration of 8-OH-DPAT on genital reflexes and mating behavior in male rats. Physiology & Behavior 47 (1990) 665-669
105. 1A receptors in rat brain: lack of effect of repeated injections of fluoxetine. Brain Research 769 (1997) 141-151
106. 1A receptors. Journal of Pharmacology and Experimental Therapeutics 282 (1997) 1581-1590
107. Liu Y.C., Salamone J.D., and Sachs B.D. Impaired sexual response after lesions of the paraventricular nucleus of the hypothalamus in male rats. Behavioral Neuroscience 111 (1997) 1361-1367
108. Liu Y.C., Salamone J.D., and Sachs B.D. Lesions in medial preoptic area and bed nucleus of stria terminalis: differential effects on copulatory behavior and noncontact erection in male rats. Journal of Neuroscience 17 (1997) 5245-5253
109. Looney C., Thor K.B., Ricca D., and Marson L. Differential effects of simultaneous or sequential administration of paroxetine and WAY-100,635 on ejaculatory behavior. Pharmacology Biochemistry and Behavior 82 (2005) 427-433
110. Lorrain D.S., Matuszewich L., Friedman R.D., and Hull E.M. Extracellular serotonin in the lateral hypothalamic area is increased during the postejaculatory interval and impairs copulation in male rats. Journal of Neuroscience 17 (1997) 9361-9366
111. Lorrain D.S., Matuszewich L., and Hull E.M. 8-OH-DPAT influences extracellular levels of serotonin and dopamine in the medial preoptic area of male rats. Brain Research 790 (1998) 217-223
112. Lorrain D.S., Riolo J.V., Matuszewich L., and Hull E.M. Lateral hypothalamic serotonin inhibits nucleus accumbens dopamine: implications for sexual satiety. Journal of Neuroscience 19 (1999) 7648-7652
113. Magoul R., Ciofi P., and Tramu G. Visualization of an efferent projection route of the hypothalamic rat arcuate nucleus through the stria terminalis after labeling with carbocyanine dye (DiI) or proopiomelanocortin-immunohistochemistry. Neuroscience Letters 172 (1994) 134-138
114. 1B) receptors in the normal rat hypothalamus. Neuroscience Letters 328 (2002) 155-159
115. Malagie I., Trillat A.C., Jacquot C., and Gardier A.M. Effects of acute fluoxetine on extracellular serotonin levels in the raphe: an in vivo microdialysis study. European Journal of Pharmacology 286 (1995) 213-217
116. Malagie I., Deslandes A., and Gardier A.M. Effects of acute and chronic tianeptine administration on serotonin outflow in rats: comparison with paroxetine by using in vivo microdialysis. European Journal of Pharmacology 403 (2000) 55-65
117. Marson L. Lesions of the periaqueductal gray block the medial preoptic area-induced activation of the urethrogenital reflex in male rats. Neuroscience Letters 367 (2004) 278-282
118. Marson L., and Gravitt K. Spinal neurons activated with the urethrogenital reflex in the male rat. Brain Research 1026 (2004) 108-115
119. Marson L., and McKenna K.E. The identification of a brainstem site controlling spinal sexual reflexes in male rats. Brain Research 515 (1990) 303-308
120. Marson L., and McKenna K.E. A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes. Experimental Brain Research 88 (1992) 313-320
121. Marson L., and McKenna K.E. Serotonergic neurotoxic lesions facilitate male sexual reflexes. Pharmacology Biochemistry and Behavior 47 (1994) 883-888
122. Marson L., and McKenna K.E. Stimulation of the hypothalamus initiates the urethrogenital reflex in male rats. Brain Research 638 (1994) 103-108
123. Marson L., and McKenna K.E. CNS cell groups involved in the control of the ischiocavernosus and bulbospongiosus muscles: a transneuronal tracing study using pseudorabies virus. Journal of Comparative Neurology 374 (1996) 161-179
124. Marson L., Platt K.B., and McKenna K.E. Central nervous system innervation of the penis as revealed by the transneuronal transport of pseudorabies virus. Neuroscience 55 (1993) 263-280
125. Mas M., Zahradnik M.A., Martino V., and Davidson J.M. Stimulation of spinal serotonergic receptors facilitates seminal emission and suppresses penile erectile reflexes. Brain Research 342 (1985) 128-134
126. Mathes C.W., Smith E.R., Popa B.R., and Davidson J.M. Effects of intrathecal and systemic administration of buspirone on genital reflexes and mating behavior in male rats. Pharmacology Biochemistry and Behavior 36 (1990) 63-68
127. 1A, antagonist. Brain Research 820 (1999) 55-62
128. Maxwell L., Maxwell D.J., Neilson M., and Kerr R. A confocal microscopic survey of serotoninergic axons in the lumbar spinal cord of the rat: co-localization with glutamate decarboxylase and neuropeptides. Neuroscience 75 (1996) 471-480
129. McIntosh T.K., and Barfield R.J. Brain monoaminergic control of male reproductive behavior. I. Serotonin and the post-ejaculatory refractory period. Behavioural Brain Research 12 (1984) 255-265
130. McKenna K.E. Some proposals regarding the organization of the central nervous system control of penile erection. Neuroscience and Biobehavioural Reviews 24 (2000) 535-540
131. McKenna K.E., and Nadelhaft I. The organization of the pudendal nerve in the male and female rat. Journal of Comparative Neurology 248 (1986) 532-549
132. McKenna K.E., Chung S.K., and McVary K.T. A model for the study of sexual function in anesthetized male and female rats. American Journal of Physiology 261 (1991) R1276-R1285
133. McMahon C.G., Abdo C., Incrocci L., Perelman M., Rowland D., Waldinger M.D., and Xin Z.C. Disorders of orgasm and ejaculation in men. Journal of Sex and Medicicne 1 (2004) 58-65
134. Meisel R.L., and Sachs B.D. The physiology of male sexual behavior. In: Knobil E., Neill J.D., Greenwald G.S., Markert C.L., and Pfaff D.W. (Eds). The Physiology of Reproduction vol. 2 (1994), Raven Press, Ltd., New York 3-105
135. 1A receptors: differential involvement in female and male sexual behavior in the rat. Physiology & Behavior 37 (1986) 345-351
136. Mendelson S.D., and Gorzalka B.B. Sex differences in the effects of 1-(m-trifluoromethylphenyl) piperazine and 1-(m-chlorophenyl) piperazine on copulatory behavior in the rat. Neuropharmacology 29 (1990) 783-786
137. Montgomery S.A., Baldwin D.S., and Riley A. Antidepressant medications: a review of the evidence for drug-induced sexual dysfunction. Journal of Affective Disorders 69 (2002) 119-140
138. Morali G., and Larsson K. Differential effects of a new serotoninomimetic drug, 8-OH-DPAT, on copulatory behavior and pelvic thrusting pattern in the male rat. Pharmacology Biochemistry and Behavior 20 (1984) 185-187
139. Moreland A.J., and Makela E.H. Selective serotonin-reuptake inhibitors in the treatment of premature ejaculation. Annals of the Pharmacotherapy 39 (2005) 1296-1301
140. Moret C., and Briley M. Effects of acute and repeated administration of citalopram on extracellular levels of serotonin in rat brain. European Journal of Pharmacology 295 (1996) 189-197
141. Mos J., Mollet I., Tolboom J.T., Waldinger M.D., and Olivier B. A comparison of the effects of different serotonin reuptake blockers on sexual behaviour of the male rat. European Neuropsychopharmacology 9 (1999) 123-135
142. Murphy A.Z., and Hoffman G.E. Distribution of gonadal steroid receptor-containing neurons in the preoptic-periaqueductal gray-brainstem pathway: a potential circuit for the initiation of male sexual behavior. Journal of Comparative Neurology 438 (2001) 191-212
143. Murphy A.Z., Rizvi T.A., Ennis M., and Shipley M.T. The organization of preoptic-medullary circuits in the male rat: evidence for interconnectivity of neural structures involved in reproductive behavior, antinociception and cardiovascular regulation. Neuroscience 91 (1999) 1103-1116
144. Nakayama K. Effect of paroxetine on extracellular serotonin and dopamine levels in the prefrontal cortex. Naunyn Schmiedebergs Archives of Pharmacology 365 (2002) 102-105
145. 1B receptor mRNA levels in rat brain. Brain Research 722 (1996) 50-58
146. Neumaier J.F., Sexton T.J., Yracheta J., Diaz A.M., and Brownfield M. Localization of 5-HT(7) receptors in rat brain by immunocytochemistry, in situ hybridization, and agonist stimulated cFos expression. Journal of Chemical Neuroanatomy 21 (2001) 63-73
147. 1B autoreceptors: regional differences and effects of WAY-100635. European Journal of Pharmacology 486 (2004) 25-30
148. Olivier, B., Chan, J.S., Pattij, T., de Jong, T.R., Oosting, R.S., Veening, J.G., Waldinger, M.D., 2005. Psychopharmacology of male rat sexual behavior: modeling human sexual dysfunctions? International Journal of Impotence Research, in press.
149. Orr R., and Marson L. Identification of CNS neurons innervating the rat prostate: a transneuronal tracing study using pseudorabies virus. Journal of Autonomic Nervous System 72 (1998) 4-15
150. Paredes R.G., Highland L., and Karam P. Socio-sexual behavior in male rats after lesions of the medial preoptic area: evidence for reduced sexual motivation. Brain Research 618 (1993) 271-276
151. Paredes R.G., Kica E., and Baum M.J. Differential effects of the serotonin1A agonist, 8-OH-DPAT, on masculine and feminine sexual behavior of the ferret. Psychopharmacology (Berlin) 114 (1994) 591-596
152. Paredes R.G., Contreras J.L., and Agmo A. Serotonin and sexual behavior in the male rabbit. Journal of Neural Transmission 107 (2000) 767-777
153. Parfitt D.B., and Newman S.W. Fos-immunoreactivity within the extended amygdala is correlated with the onset of sexual satiety. Hormones and Behavior 34 (1998) 17-29
154. Pattij T., de Jong T.R., Uitterdijk A., Waldinger M.D., Veening J.G., Cools A.R., van der Graaf P.H., and Olivier B. Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders. European Journal of Neuroscience 22 (2005) 724-734
155. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. fourth ed (1998), Elsevier Academic Press, San Diego
156. Pfaus J.G. Frank A. Beach award. Homologies of animal and human sexual behaviors. Hormones and Behavior 30 (1996) 187-200
157. Pineyro G., and Blier P. Autoregulation of serotonin neurons: role in antidepressant drug action. Pharmacological Reviews 51 (1999) 533-591
158. 1A receptor in the rat brain: correlation with receptor binding. Journal of Neuroscience 12 (1992) 440-453
159. 1A and 5-HT1C/1D receptor agonists produce reciprocal effects on male sexual behavior of rhesus monkeys. European Journal of Pharmacology 243 (1993) 227-234
160. Pomerantz S.M., Hepner B.C., and Wertz J.M. Serotonergic influences on male sexual behavior of rhesus monkeys: effects of serotonin agonists. Psychopharmacology (Berlin) 111 (1993) 47-54
161. Powell W.S., Dominguez J.M., and Hull E.M. An NMDA antagonist impairs copulation and the experience-induced enhancement of male sexual behavior in the rat. Behavioral Neuroscience 117 (2003) 69-75
162. Price G.W., Roberts C., Watson J., Burton M., Mulholland K., Middlemiss D.N., and Jones B.J. Species differences in 5-HT autoreceptors. Behavioural Brain Research 73 (1996) 79-82
163. Qureshi G.A., Forsberg G., Bednar I., and Sodersten P. Tryptophan, 5-HTP, 5-HT and 5-HIAA in the cerebrospinal fluid and sexual behavior in male rats. Neuroscience Letters 97 (1989) 227-231
164. Ranson R.N., Dodds A.L., Smith M.J., Santer R.M., and Watson A.H. Age-associated changes in the monoaminergic innervation of rat lumbosacral spinal cord. Brain Research 972 (2003) 149-158
165. Raymond J.R., Mukhin Y.V., Gelasco A., Turner J., Collinsworth G., Gettys T.W., Grewal J.S., and Garnovskaya M.N. Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacology & Therapeutics 92 (2001) 179-212
166. 1A receptor. Brain Research 821 (1999) 414-425
167. Renyi L. Ejaculations induced by p-chloroamphetamine in the rat. Neuropharmacology 24 (1985) 697-704
168. Rinken A., Ferre S., Terasmaa A., Owman C., and Fuxe K. Serotonergic agonists behave as partial agonists at the dopamine D2 receptor. Neuroreport 10 (1999) 493-495
169. Rodriguez M., Castro R., Hernandez G., and Mas M. Different roles of catecholaminergic and serotoninergic neurons of the medial forebrain bundle on male rat sexual behavior. Physiology & Behavior 33 (1984) 5-11
170. 1B receptor knockout mice. British Journal of Pharmacology 136 (2002) 1127-1134
171. Rosen R.C., Lane R.M., and Menza M. Effects of SSRIs on sexual function: a critical review. Journal of Clinical Psychopharmacology 19 (1999) 67-85
172. Salis P.J., and Dewsbury D.A. p-Chlorophenylalanine facilitates copulatory behaviour in male rats. Nature 232 (1971) 400-401
173. Samathanam G., Duffy P., Kalivas P.W., and White S.R. A comparison of 5-hydroxytryptophan effects on rat lumbar spinal cord serotonin release and monosynaptic response amplitude. Brain Research 501 (1989) 179-182
174. 1B auto and heteroreceptors. Naunyn Schmiedebergs Archives of Pharmacology 360 (1999) 382-390
175. Sari Y. Serotonin1B receptors: from protein to physiological function and behavior. Neuroscience and Biobehavioural Reviews 28 (2004) 565-582
176. Schnur S.L., Smith E.R., Lee R.L., Mas M., and Davidson J.M. A component analysis of the effects of DPAT on male rat sexual behavior. Physiology & Behavior 45 (1989) 897-901
177. Schwartz D., Hernandez L., and Hoebel B.G. Fenfluramine administered systemically or locally increases extracellular serotonin in the lateral hypothalamus as measured by microdialysis. Brain Research 482 (1989) 261-270
178. Series H.G., Cowen P.J., and Sharp T. p-Chloroamphetamine (PCA), 3,4-methylenedioxy-methamphetamine (MDMA) and d-fenfluramine pretreatment attenuates d-fenfluramine-evoked release of 5-HT in vivo. Psychopharmacology (Berlin) 116 (1994) 508-514
179. Shimizu N., Take S., Hori T., and Oomura Y. In vivo measurement of hypothalamic serotonin release by intracerebral microdialysis: significant enhancement by immobilization stress in rats. Brain Research Bulletin 28 (1992) 727-734
180. Sprouse J., Clarke T., Reynolds L., Heym J., and Rollema H. Comparison of the effects of sertraline and its metabolite desmethylsertraline on blockade of central 5-HT reuptake in vivo. Neuropsychopharmacology 14 (1996) 225-231
181. Steers W.D. Neural pathways and central sites involved in penile erection: neuroanatomy and clinical implications. Neuroscience and Biobehavioural Reviews 24 (2000) 507-516
182. Steinbusch H.W. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 6 (1981) 557-618
183. Steinbusch H.W., and Nieuwenhuys R. Localization of serotonin-like immunoreactivity in the central nervous system and pituitary of the rat, with special references to the innervation of the hypothalamus. Advances in Experimental Medicine and Biology 133 (1981) 7-35
184. Stoneham M.D., Everitt B.J., Hansen S., Lightman S.L., and Todd K. Oxytocin and sexual behaviour in the male rat and rabbit. Jurnal of Endocrinology 107 (1985) 97-106
185. Sura A., Overstreet D.H., and Marson L. Selectively bred male rat lines differ in naive and experienced sexual behavior. Physiology & Behavior 72 (2001) 13-20
186. Svensson L., and Hansen S. Spinal monoaminergic modulation of masculine copulatory behavior in the rat. Brain Research 302 (1984) 315-321
187. Tang Y., Rampin O., Calas A., Facchinetti P., and Giuliano F. Oxytocinergic and serotonergic innervation of identified lumbosacral nuclei controlling penile erection in the male rat. Neuroscience 82 (1998) 241-254
188. Tang Y., Rampin O., Giuliano F., and Ugolini G. Spinal and brain circuits to motoneurons of the bulbospongiosus muscle: retrograde transneuronal tracing with rabies virus. Journal of Comparative Neurology 414 (1999) 167-192
189. Thor K.B., Nickolaus S., and Helke C.J. Autoradiographic localization of 5-hydroxytryptamine1A, 5-hydroxytryptamine1B and 5-hydroxytryptamine1C/2 binding sites in the rat spinal cord. Neuroscience 55 (1993) 235-252
190. Truitt W.A., and Coolen L.M. Identification of a potential ejaculation generator in the spinal cord. Science 297 (2002) 1566-1569
191. Tsutsui Y., Shinoda A., and Kondo Y. Facilitation of copulatory behavior by pCPA treatments following stria terminalis transection but not medial amygdala lesion in the male rat. Physiology & Behavior 56 (1994) 603-608
192. Ueyama T., Arakawa H., and Mizuno N. Central distribution of efferent and afferent components of the pudendal nerve in rat. Anatomy and Embryology (Berlin) 177 (1987) 37-49
193. van de Kar L.D., and Lorens S.A. Differential serotonergic innervation of individual hypothalamic nuclei and other forebrain regions by the dorsal and median midbrain raphe nuclei. Brain Research 162 (1979) 45-54
194. Vega M.J., Larsson K., and Eriksson E. The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats. Pharmacology Biochemistry and Behavior 60 (1998) 527-532
195. Verma S., Chhina G.S., Mohan Kumar V., and Singh B. Inhibition of male sexual behavior by serotonin application in the medial preoptic area. Physiology & Behavior 46 (1989) 327-330
196. Waldinger M.D. Towards evidence-based drug treatment research on premature ejaculation: a critical evaluation of methodology. International Journal of Impotence Research 15 (2003) 309-313
197. Waldinger M.D. Lifelong premature ejaculation: definition, serotonergic neurotransmission and drug treatment. World Journal of Urology 23 (2005) 102-108
198. Waldinger M.D., and Schweitzer D.H. Retarded ejaculation in men: an overview of psychological and neurobiological insights. World Journal of Urology 23 (2005) 76-81
199. Waldinger M.D., Berendsen H.H., Blok B.F., Olivier B., and Holstege G. Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system. Behavioural Brain Research 92 (1998) 111-118
200. Waldinger M.D., Hengeveld M.W., Zwinderman A.H., and Olivier B. Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. Journal of Clinical Psychopharmacology 18 (1998) 274-281
201. Waldinger M.D., Zwinderman A.H., and Olivier B. SSRIs and ejaculation: a double-blind, randomized, fixed-dose study with paroxetine and citalopram. Journal of Clinical Psychopharmacology 21 (2001) 556-560
202. Waldinger M.D., van de Plas A., Pattij T., van Oorschot R., Coolen L.M., Veening J.G., and Olivier B. The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment. Psychopharmacology (Berlin) 160 (2002) 283-289
203. Waldinger M.D., Zwinderman A.H., Schweitzer D.H., and Olivier B. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. International Journal of Impotence Research 16 (2004) 369-381
204. Waldinger M.D., Quinn P., Dilleen M., Mundayat R., Schweitzer D.H., and Boolell M. A multinational population survey of Intravaginal Ejaculation Latency Time. Journal of Sex and Medicicne 2 (2005) 492-497
205. Waldinger M.D., Zwinderman A.H., Olivier B., and Schweitzer D.H. Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data. Journal of Sex and Medicicne 2 (2005) 498-507
206. Watson N.V., and Gorzalka B.B. DOI-induced inhibition of copulatory behavior in male rats: reversal by 5-HT2 antagonists. Pharmacology Biochemistry and Behavior 39 (1991) 605-612
207. Wegener G., Bandpey Z., Heiberg I.L., Mork A., and Rosenberg R. Increased extracellular serotonin level in rat hippocampus induced by chronic citalopram is augmented by subchronic lithium: neurochemical and behavioural studies in the rat. Psychopharmacology (Berlin) 166 (2003) 188-194
208. Wright D.E., Seroogy K.B., Lundgren K.H., Davis B.M., and Jennes L. Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain. Journal of Comparative Neurology 351 (1995) 357-373
209. Xu C., Yaici E.D., Conrath M., Blanchard P., Leclerc P., Benoit G., Verge D., and Giuliano F. Galanin and neurokinin-1 receptor immunoreactivity spinal neurons controlling the prostate and the bulbospongiosus muscle identified by transsynaptic labeling in the rat. Neuroscience 134 (2005) 1325-1341
210. Yamanouchi K., and Kakeyama M. Effect of medullary raphe lesions on sexual behavior in male rats with or without treatments of p-chlorophenylalanine. Physiology & Behavior 51 (1992) 575-579
211. Yells D.P., Hendricks S.E., and Prendergast M.A. Lesions of the nucleus paragigantocellularis: effects on mating behavior in male rats. Brain Research 596 (1992) 73-79
212. Yells D.P., Prendergast M.A., Hendricks S.E., and Nakamura M. Fluoxetine-induced inhibition of male rat copulatory behavior: modification by lesions of the nucleus paragigantocellularis. Pharmacology Biochemistry and Behavior 49 (1994) 121-127
213. Yonezawa A., Watanabe C., Ando R., Furuta S., Sakurada S., Yoshimura H., Iwanaga T., and Kimura Y. Characterization of p-chloroamphetamine-induced penile erection and ejaculation in anesthetized rats. Life Sciences 67 (2000) 3031-3039
214. Yonezawa A., Ando R., Imai M., Watanabe C., Furuta S., Kutsuwa M., Kimura Y., and Sakurada S. Differential effects of yohimbine, naloxone and 8-OH-DPAT on ejaculatory response in male dogs. Methods and Findings in Experimental and Clinical Pharmacology 26 (2004) 47-51
215. Yoshitake T., Reenila I.I., Ogren S.O., Hokfelt T., and Kehr J. Galanin attenuates basal and antidepressant drug-induced increase of extracellular serotonin and noradrenaline levels in the rat hippocampus. Neuroscience Letters 339 (2003) 239-242
216. Zhang W., Perry K.W., Wong D.T., Potts B.D., Bao J., Tollefson G.D., and Bymaster F.P. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology 23 (2000) 250-262
217. 1A receptors by 5-HT2A receptors in neuroendocrine neurons in vivo. Journal of Pharmacology and Experimental Therapeutics 310 (2004) 59-66