Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 2, 2009, Pages 530-536

  Zimmermann, Tobias J ^a   Niesen, Frank H ^b   Pilka, Ewa S ^b   Knapp, Stefan ^b,d   Oppermann, Udo ^b,c   Maier, Martin E ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Carbonyl reductase 1; Macrolides; Natural product analogues; Polyketides; Zearalenone

Indexed keywords

ACETIC ACID; BIOCHANIN A; CARBONYL REDUCTASE; CARBONYL REDUCTASE 1; CARBONYL REDUCTASE 3; CHRYSIN; GELDANAMYCIN; GENISTEIN; HEAT SHOCK PROTEIN 90; LYMPHOCYTE ORIGINATING KINASE; MACROLIDE; MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE 6; NARINGENIN; P21 ACTIVATED KINASE 6; PROPIONIC ACID; PROTEIN KINASE; PROTEIN KINASE PIM 1; PROTEIN SLK; QUERCETIN; RADICICOL; TRICLOSAN; UNCLASSIFIED DRUG; WEDELOLACTONE; ZEARALENONE;

ARTICLE; CHEMICAL REACTION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; LACTONIZATION; MARSHALL TAMARU REACTION; MITSUNOBU REACTION; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

ACETATES; ALCOHOL OXIDOREDUCTASES; ESTROGENS, NON-STEROIDAL; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MACROLIDES; PROPIONATES; PROTEIN BINDING; PROTEIN KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; ZEARALENONE;

EID: 58549120547     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.11.076     Document Type: Article

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