Interrogating the mechanism of a tight binding inhibitor of AIR carboxylase

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 2, 2009, Pages 794-803

  Firestine, Steven M ^a   Wu, Weidong ^b   Youn, Hasik ^b   Jo Davisson, V ^b  

^a WAYNE STATE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

AIR carboxylase; Computation; Electrostatic complementarity; Enzyme inhibitors; Heterocycles; Purine biosynthesis; Tight binding

Indexed keywords

4 CARBOXY 5 AMINOIMIDAZOLE RIBONUCLEOTIDE; 4 NITRO 5 AMINOIMIDAZOLE RIBONUCLEOTIDE; AMINOIMIDAZOLE RIBONUCLEOTIDE CARBOXYLASE; CARBOXYLASE; HETEROCYCLIC COMPOUND; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; PURINE SYNTHESIS;

AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; CARBOXY-LYASES; CHICKENS; ENZYME INHIBITORS; HUMANS; NITROIMIDAZOLES; PROTEIN BINDING; RIBONUCLEOTIDES; STATIC ELECTRICITY;

EID: 58549115669     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.11.057     Document Type: Article

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