Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity

International Journal for Parasitology

Volumn 39, Issue 3, 2009, Pages 267-279

  Fitzpatrick, Jennifer M ^a   Fuentes, Jose M ^b   Chalmers, Iain W ^a   Wynn, Thomas A ^c   Modolell, Manuel ^d   Hoffmann, Karl F ^a   Hesse, Matthias ^c,e  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^e Animal Health Diagnostic Center   (United States)

Author keywords

Adaptation; Drug target; Enzyme; Evolution; Helminth; Metabolism; Trematode; Urea

Indexed keywords

ARGINASE; ARGININE; COMPLEMENTARY DNA; CYSTEINE; DISULFIDE; ORNITHINE; UREA;

ENZYME ACTIVITY; FLATWORM; GENE EXPRESSION; HEALTH RISK; METABOLISM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DEVELOPMENTAL STAGE; ENZYME ACTIVITY; ENZYME STRUCTURE; FEMALE; HYDROLYSIS; IMMUNE RESPONSE; MACROPHAGE ACTIVATION; MAMMAL; MOLECULAR CLONING; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PARASITE DEVELOPMENT; PHYLOGENY; PROTEIN EXPRESSION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ARGINASE; BIOMPHALARIA; CLONING, MOLECULAR; DISULFIDES; DNA, HELMINTH; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HOST-PARASITE INTERACTIONS; HUMANS; LIFE CYCLE STAGES; MALE; MICE; MOLECULAR SEQUENCE DATA; PHYLOGENY; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 58549089284     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2008.06.015     Document Type: Article

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