Schistosoma mansoni induces the synthesis of IL-6 in pulmonary microvascular endothelial cells: Role of IL-6 in the control of lung eosinophilia during infection

European Journal of Immunology

Volumn 31, Issue 9, 2001, Pages 2751-2761

  Angeli, Véronique ^a   Faveeuw, Christelle ^a   Delerive, Philippe ^b   Fontaine, Josette ^a   Barriera, Yara ^a   Franchimont, Nathalie ^a   Staels, Bart ^b   Capron, Monique ^a   Trottein, François ^a,c  

^a INSTITUT PASTEUR DE LILLE   (France)

^b CHU RANGUEIL   (France)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Eosinophil; Helminth parasite; IL 6; Inflammation; Lung

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EOTAXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 5; INTERLEUKIN 6; MESSENGER RNA; PROSTAGLANDIN E2; PROTEIN;

AIRWAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL KILLING; CELL MOTILITY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; EOSINOPHIL; EOSINOPHILIA; FEMALE; HOST PARASITE INTERACTION; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; KNOCKOUT MOUSE; LARVA; LEUKOCYTE; LUNG BLOOD VESSEL; LUNG PARENCHYMA; MICROVASCULARIZATION; MOUSE; MOUSE STRAIN; NONHUMAN; OUTCOMES RESEARCH; PARASITOSIS; PRIORITY JOURNAL; PROMOTER REGION; SCHISTOSOMA MANSONI;

ANIMALS; CAPILLARIES; CELLS, CULTURED; CHEMOKINES, CC; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOKINES; DINOPROSTONE; ENDOTHELIUM, VASCULAR; HUMANS; INTERLEUKIN-5; INTERLEUKIN-6; LUNG; MICE; MICE, KNOCKOUT; PROMOTER REGIONS (GENETICS); PULMONARY EOSINOPHILIA; RESPONSE ELEMENTS; RNA, MESSENGER; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; TRANS-ACTIVATION (GENETICS);

EID: 0034814816     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200109)31:9<2751::AID-IMMU2751>3.0.CO;2-4     Document Type: Article

References (38)

1. Public health impact of schistosomiasis: Disease and mortality
2. Cercariae to liver worms: Development and migration in the mammalian host
3. Leukocyte-endothelial adhesion molecules
4. Vaccination against schistosomiasis: The case for lung-stage antigens
5. Endothelial-leukocyte adhesion molecules
6. Chemokines, leukocyte trafficking, and inflammation
7. Schistosoma mansoni activates host microvascular endothelial cells to acquire an anti-inflammatory phenotype
8. Schistosoma mansoni schistosomula reduce E-selectin and VCAM-1 expression in TNFα-stimulated lung microvascular endothelial cells by interfering with the NF-κB pathway
9. Cytokine regulation of endothelial cell function
10. Role of the parasite-derived PGD2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection
11. Schistosoma mansoni: A comparison of secreted vs. nonsecreted eicosanoids in developing schistosomulae and adults
12. Relationship of cAMP and calcium messenger systems in prostaglandin-stimulated UMR-106 cells
13. Rapid enhancement of β2-interferon/B cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187
14. Synthesis of IL-6 in human fibroblasts is triggered by an increase in intracellular cAMP
15. Human immunodeficiency virus Tat protein induces IL-6 mRNA expression in human brain endothelial cells via PKC and PKA pathways
16. MHC class II engagement in brain endothelial cells induces protein kinase A-dependent IL-6 secretion and phosphorylation of cAMP response element-binding protein
17. Multiple sequence elements in the c-fos promoter mediate induction by cAMP
18. cAMP stimulates the C/EBP-related transcription factor rNF-IL-6 to trans-locate to the nucleus and induce c-fos transcription
19. In vitro activation and nuclear translocation of NF-κB catalyzed by cAMP-dependent protein kinase and protein kinase C
20. IL-6 in biology and medicine
21. IL-6 directs the differentiation of IL-4-producing CD4+ T cells
22. IL-6 and APPs: Antiinflammatory and immunosuppressive mediators
23. IL-6-induced protection in hyperoxic acute lung injury
24. Protective role of IL-6 in the lipopolysaccharide-galactosamine septic shock model
25. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
26. Regulatory effects of IL-6 in immunoglobulin G immune-complex-induced lung injury
27. Intratracheal injection of endotoxin and cytokines. IL-6 and TGFβ inhibit acute inflammation
28. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
29. Do eosinophils have a role in the killing of helminth parasites?
30. IL-6 is required for a protective immune response to systemic Escherichia coli infection
31. Immunological studies of chronic ocular toxoplasmosis: Up-regulation of MHC class I and TGFβ and a protective role for IL-6
32. Prostanoid receptors: Structures, properties, and functions
33. A role for parasite-induced PGE2 in IL-10-mediated host immunoregulation by skin stage schistosomula of Schistosoma mansoni
34. Multiple regulatory elements in the IL-6 gene mediate induction by prostaglandins, cAMP, and lipopolysaccharide
35. HMEC-1: Establishment of an immortalized human microvascular endothelial cell line
36. Early cytokine production in pulmonary Cryptococcus neoformans infections distinguishes susceptible and resistant mice
37. MIP1α mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia
38. IL-6 is autoregulated by transcriptional mechanisms in cultures of rat osteoblastic cells