Prevalent role of Akt and ERK activation in cardioprotective effect of Ca2+ channel- and beta-adrenergic receptor blockers

Molecular and Cellular Biochemistry

Volumn 321, Issue 1-2, 2009, Pages 155-164

  Kovacs, Krisztina ^a   Hanto, Katalin ^a   Bognar, Zita ^a   Tapodi, Antal ^a   Bognar, Eszter ^a   Kiss, Gyongyi N ^a   Szabo, Aliz ^a   Rappai, Gabor ^b   Kiss, Tamas ^a   Sumegi, Balazs ^a   Gallyas Jr , Ferenc ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Akt; Beta adrenergic receptor blocker; Ca channel blocker; ERK; Ischemia reperfusion

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ADENOSINE TRIPHOSPHATE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CREATINE PHOSPHATE; GLYCOGEN SYNTHASE KINASE 3BETA; HO 3089; METOPROLOL; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; ENERGY METABOLISM; ENZYME ACTIVATION; HEART FUNCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PERFUSION; HEART PROTECTION; IMMUNOBLOTTING; ISOLATED HEART; LIPID PEROXIDATION; MALE; NONHUMAN; PH; RAT;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BENZIMIDAZOLES; CALCIUM CHANNEL BLOCKERS; CARDIOTONIC AGENTS; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; HYDROGEN-ION CONCENTRATION; LIPID PEROXIDATION; MALE; METOPROLOL; MYOCARDIAL INFARCTION; MYOCARDIUM; OXIDATION-REDUCTION; PHOSPHATES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; SIGNAL TRANSDUCTION; VERAPAMIL;

RATTUS;

EID: 58249130704     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-9929-8     Document Type: Article

References (42)

1. Zima AV, Blatter LA (2006) Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res 71(2):310-321. doi: 10.1016/ j.cardiores.2006.02.019
2. Xia Y, Khatchikian G, Zweier JL (1996) Adenosine deaminase inhibition prevents free radical-mediated injury in the postischemic heart. J Biol Chem 271:10096-10102. doi: 10.1074/jbc.271.19.11204
3. Rowe GT, Manson NH, Caplan M, Hess ML (1983) Hydrogen peroxide and hydroxyl radical mediation of activated leukocyte depression of cardiac sarcoplasmic reticulum. Participation of the cyclooxygenase pathway. Circ Res 53:584-591
4. Werner E (2004) GTPases and reactive oxygen species: Switches for killing and signaling. J Cell Sci 117(Pt 2):143-153. doi: 10.1242/ jcs.00937
5. Tapodi A, Debreceni B, Hanto K, Bognar Z, Wittmann I, Gallyas F Jr et al (2005) Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress. J Biol Chem 280(42):35767-35775. doi: 10.1074/jbc.M507075200
6. Argaud L, Gateau-Roesch O, Muntean D, Chalabreysse L, Loufouat J, Robert D et al (2005) Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury. J Mol Cell Cardiol 38(2):367-374. doi: 10.1016/j.yjmcc.2004.12.001
7. Uchiyama T, Otani H, Okada T, Ninomiya H, Kido M, Imamura H et al (2002) Nitric oxide induces caspase-dependent apoptosis and necrosis in neonatal rat cardiomyocytes. J Mol Cell Cardiol 34(8):1049-1061. doi: 10.1006/jmcc.2002.2045
8. Szabo C (2005) Cardioprotective effects of poly(ADP-ribose) polymerase inhibition. Pharmacol Res 52(1):34-43. doi: 10.1016/j.phrs.2005.02.017
9. de la Lastra CA, Villegas I, Sanchez-Fidalgo S (2007) Poly(ADP-ribose) polymerase inhibitors: New pharmacological functions and potential clinical implications. Curr Pharm Des 13(8):933-962. doi: 10.2174/ 138161207780414241
10. Palfi A, Toth A, Kulcsar G, Hanto K, Deres P, Bartha E et al (2005) The role of Akt and mitogen-activated protein kinase systems in the protective effect of poly(ADP-ribose) polymerase inhibition in Langendorff perfused and in isoproterenol-damaged rat hearts. J Pharmacol Exp Ther 315(1):273-282. doi: 10.1124/jpet.105.088336
11. Veres B, Gallyas F Jr, Varbiro G, Berente Z, Osz E, Szekeres G et al (2003) Decrease of the inflammatory response and induction of the Akt/ protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock. Biochem Pharmacol 65:1373-1382. doi: 10.1016/S0006-2952(03)00077-7
12. Veres B, Radnai B, Gallyas F Jr, Varbiro G, Berente Z, Osz E et al (2004) Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. J Pharmacol Exp Ther 310(1):247-255. doi: 10.1124/jpet.104.065151
13. Kovacs K, Toth A, Deres P, Kalai T, Hideg K, Gallyas F Jr et al (2006) Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion. Biochem Pharmacol 71:441-452. doi: 10.1016/j.bcp.2005.05.036
14. Aikawa R, Nawano M, Gu Y, Katagiri H, Asano T, Zhu W et al (2000) Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt. Circulation 102:2873-2879
15. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E et al (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282:1318-1321. doi: 10.1126/ science.282.5392.1318
16. Scheid MP, Woodgett JR (2001) PKB/Akt: Functional insight from genetic models. Natl Rev 2:760-768
17. Romashkova JA, Makarov SS (1999) NF-κB is a target of Akt in antiapoptotic PDGF signaling. Nature 401:86-89. doi: 10.1038/43474
18. Dimmeler S, Fleming I, Fisslthalter B, Hermann C, Busse R, Zeiher AM (1999) Activation of nitric oxide synthase by Akt dependent phosphorylation. Nature 399:601-605. doi: 10.1038/21224
19. Gao F, Gao E, Yue TL, Ohlstein EH, Lopez BL, Christopher TA et al (2002) Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: The roles of PI3-kinase, Akt and endothelial nitric oxide synthase phosphorylation. Circulation 105:1497-1502. doi: 10.1161/01.CIR.0000012529.00367.0F
20. Halmosi R, Berente Z, Osz E, Toth K, Literati-Nagy P, Sumegi B (2001) Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cardiac injury and mitochondrial metabolism in Langendorff heart perfusion system. Mol Pharmacol 59:1497-1505
21. Deres P, Halmosi R, Toth A, Kovacs K, Palfi A, Habon T et al (2005) Prevention of doxorubicin-induced acute cardiotoxicity by an experimental antioxidant compound. J Cardiovasc Pharmacol 45(1):36-43. doi: 10.1097/00005344-200501000-00007
22. Szabados E, Fischer GM, Gallyas F Jr, Kispal G, Sumegi B (1999) Enhanced ADP-ribosilation and its diminution by lipoamide following ischemia-reperfusion in perfused rat heart. Free Radic Biol Med 27(9/ 10):1103-1113. doi: 10.1016/S0891-5849(99)00151-3
23. Toth A, Halmosi R, Kovacs K, Deres P, Kalai T, Hideg K et al (2003) Akt activation induced by an antioxidant compound during ischemia-reperfusion. Free Radic Biol Med 35:1051-1063. doi: 10.1016/ S0891-5849(03)00467-2
24. 2. J Biol Chem 23:20336-20342. doi: 10.1074/jbc.M111899200
25. Dauterman K, Topol E (2002) Optimal treatment and current situation in reperfusion after thrombolysis for acute myocardial infarction. Ann Med 34(7-8):514-522. doi: 10.1080/078538902321117724
26. Mehta JL (1994) Emerging options in the management of myocardial ischemia. Am J Cardiol 73(3):18A-27A. doi: 10.1016/0002-9149(94)90270-4
27. Buser PT, Wagner S, Wu ST, Derugin N, Parmley WW, Higgins CB et al (1989) Verapamil preserves myocardial performance and energy metabolism in left ventricular hypertrophy following ischemia and reperfusion. Phosphorus 31 magnetic resonance spectroscopy study. Circulation 80(6):1837-1845
28. Wolfe CL, Donnely TJ, Sievers R, Parmley WW (1991) Myocardial protection with verapamil during ischaemia and reperfusion: Dissociation between myocardial salvage and the degree of ATP depletion during ischaemia. Cardiovasc Res 25(2):101-109. doi: 10.1093/cvr/25.2.101
29. Farkas A, Qureshi A, Curtis M (1999) Inadequate ischaemia-selectivity limits the antiarrhythmic efficacy of mibefradil during regional ischaemia and reperfusion in the rat isolated perfused heart. Br J Pharmacol 128:41-50. doi: 10.1038/sj.bjp.0702778
30. Markiewicz W, Wu SS, Sievers R, Parmley WW, Watters TA, James TL et al (1988) Beneficial effects of verapamil during metabolic acidosis in isolated perfused rat hearts. Cardiovasc Drugs Ther 1(5):493-502. doi: 10.1007/BF02125732
31. Kalaycioglu S, Sinci V, Imren Y, Öz E (1999) Metoprolol prevents ischemia-reperfusion injury by reducing lipid peroxidation. Jpn Circ J 63:718-721. doi: 10.1253/jcj.63.718
32. Bradley L, Doggrell SA (1984) Effects of the (+/-)-, (+)- and (+)-forms of propranolol, timolol and metoprolol on noradrenergic transmission in the rat isolated right ventricle. Arch Int Pharmacodyn Ther 270(1):61-78
33. Communal C, Colucci WS (2005) The control of cardiomyocyte apoptosis via the beta-adrenergic signaling pathways. Arch Mal Coeur Vaiss 98(3):236-241
34. Zhou H, Li XM, Meinkoth J, Pittman RN (2000) Akt regulates cell survival and apoptosis at a postmitochondrial level. J Cell Biol 151:483-494. doi: 10.1083/jcb.151.3.483
35. Crossthwaite AJ, Hasan S, Williams RJ (2002) Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: dependence on Ca(2+) and PI3-kinase. J Neurochem 80(1):24-35. doi: 10.1046/j.0022-3042.2001.00637.x
36. Yamaguchi T, Wallace DP, Magenheimer BS, Hempson SJ, Grantham JJ, Calvet JP (2004) Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype. J Biol Chem 279(39):40419-40430. doi: 10.1074/jbc.M405079200
37. Goto S, Xue R, Sugo N, Sawada M, Blizzard KK, Poitras MF et al (2002) Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery. Stroke 33(4):1101-1106. doi: 10.1161/ 01.STR.0000014203.65693.1E
38. DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK (2007) Beta-arrestins and cell signaling. Annu Rev Physiol 69:483-510. doi: 10.1146/ annurev.physiol.69.022405.154749
39. Povsic TJ, Kohout TA, Lefkowitz RJ (2003) Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis. J Biol Chem 278(51):51334-51339. doi: 10.1074/jbc.M309968200
40. Raju RV, Kakkar R, Radhi JM, Sharma RK (1997) Biological significance of phosphorylation and myristoylation in the regulation of cardiac muscle proteins. Mol Cell Biochem 176(1-2):135-143. doi: 10.1023/A:1006891302017
41. Abdel-Latif AA (2001) Cross talk between cyclic nucleotides and polyphosphoinositide hydrolysis, protein kinases, and contraction in smooth muscle. Exp Biol Med (Maywood) 226(3):153-163
42. Nadif Kasri N, Bultynck G, Sienaert I, Callewaert G, Erneux C, Missiaen L, Parys JB, De Smedt H (2002) The role of calmodulin for inositol 1, 4, 5-trisphosphate receptor function. Biochim Biophys Acta 1600(1-2):19-31