Metoprolol prevents ischemia-reperfusion injury by reducing lipid peroxidation

Japanese Circulation Journal

Volumn 63, Issue 9, 1999, Pages 718-721

  Kalaycioglu, Sedat ^a,b   Sinci, Volkan ^a   Imren, Yildirim ^a   Öz, Eser ^a  

^a GAZI UNIVERSITY FACULTY OF MEDICINE   (Turkey)

^b Gazi Hastanesi   (Turkey)

Author keywords

Beta blockers; Glutathione; Heart rate; Ischemia reperfusion injury; Malondialdehyde; Metoprolol

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; GLUTATHIONE; MALONALDEHYDE; METOPROLOL;

ANIMAL MODEL; ANIMAL TISSUE; AORTA PRESSURE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG EFFECT; HEART RATE; HEART VENTRICLE FUNCTION; LIPID PEROXIDATION; MALE; NONHUMAN; REPERFUSION INJURY; TISSUE INJURY; TISSUE LEVEL;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; GLUTATHIONE; GUINEA PIGS; HEART RATE; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; METOPROLOL; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM;

EID: 0032880665     PISSN: 00471828     EISSN: None     Source Type: Journal    
DOI: 10.1253/jcj.63.718     Document Type: Article

References (17)

1. Das DK, Engelman RM, Rouou JA, Breyer RH, Otani H, Lemeshow S: Pathophysiology of Superoxide radical as potential mediator of reperfusion injury in pig heart. Basic Res Cardiol 1986; 81: 155-166
2. Hess ML, Mason NH, Okabe E: Involvement of free radicals in the pathophysiology of ischemic heart disease. Can J Physiol Pharmacol 1982; 60: 1382-1389
3. Mak T, Kramer JH, Weglicki WB: Potentiation of free radical induced lipid peroxidative injury to sarcolemmal membranes by lipid amphiphiles. J Biol Chem 1986; 261: 1153-1157
4. Liu X, Engelman RM, Agrawal HR. Das DK: Preservation of membrane phospholipids by propranolol, pindolol and metoprolol: a novel mechanism of action of β-blockers. J Mol Cell Cardiol 1991; 23: 1091-1100
5. Institute of Laboratory Animal Resources. Guide for the care and use of laboratory animals. National Institutes of Health. (NIH publication No: 85-23 revised 1985).
6. Kurtel H, Granger DN, Tso P, Grisham MB: Vulnerability of intestinal interstitial fluid: the oxidant stress Am J Physiol 1992; 263: 573-578
7. Casini A, Ferrali M, Pompella A, Maellaro E, Comborti M: Lipid peroxidation and cellular damage in extra-hepatic tissues of bromobenzene intoxicated mice Am J Pathol 1986; 123: 520-531
8. Podesser BK, Schwarzacher S, Zwoelfer W, Binder TM, Wolner E, Seitelberger R: Comparison of perioperative myocardial protection with nifedipine versus nifedipine and metoprolol in patients undergoing elective coronary artery bypass grafting. J Thorac Cardiovasc Surg 1995; 110: 1461-1469
9. Grinberg OY, Grinberg SA, Friedman BJ, Swartz HM: Myocardial oxygen tension and capillary density in the isolated perfused rat heart during pharmacological intervention. Adv Exp Med Biol 1997; 411: 171-181
10. Felix SB, Stangl V, Frank TM, Harms C, Berndt T, Kastner R, Baumann G: Release of a stable cardiodepressant mediator after myocardial ischaemia during reperfusion. Cardiovasc Res 1997; 35: 68-79
11. Mak T, Arroyo CM, Weglicki WB: Inhibiton of sarcolemmal carbon-centred free radical formation by propranolol. 1989 Circ Res; 65: 1151-1156
12. Grace PA: Ischemia-reperfusion injury. Br J Surg 1994; 81: 637-647
13. Mak IT, Weglicki WB: Protection by β-blocking agents against free radical-mediated sarcolemmal lipid peroxidation. Circ Res 1988; 63: 262-266
14. Willerson JT, Buja LM: Beta-adrenergic mechanism during severe myocardial ischemia and evolving infarction. Postgrad Med J 1988; 29: 27-32
15. Podesser B, Schwarzacher S, Zwölfer W, Binder T, Spatt J, Peschl F, Huber S, et al: Perioperative infusion of nifedipine and metoprolol provides antiischemic and antiarrhythmic protection in patients undergoing elective aortocoronary by-pass surgery. J Cardiovasc Surg (Torino) 1994; 35(Suppl 1): 233-235
16. Portegies MCM, Sijbring P, Göbel EJAM, Viersma JW, Lie KI: Efficacy of metoprolol and diltiazem in treating silent myocardial ischemia. Am J Cordial 1994; 74: 1095-1098
17. Waagstein F: Efficacy of beta blockers in idiopathic dilated cardiomyopathy and ischemic cardiomyopathy. Am J Cardiol 1997; 80:45J-49J