Genetic control of IL-1β bioactivity through differential regulation of the IL-1 receptor antagonist

European Journal of Immunology

Volumn 32, Issue 10, 2002, Pages 2988-2996

  Vamvakopoulos, Joannis ^a,c   Green, Colin ^b   Metcalfe, Su ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NORTHWICK PARK INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c Biomedicum Helsinki   (Finland)

Author keywords

Genetic; IL 1; IL 1Ra; Regulation; Rejection

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA;

ADULT; ALLELE; ARTICLE; CELL CULTURE; CELL STIMULATION; CONTROLLED STUDY; DATA ANALYSIS; DISEASE PREDISPOSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE CLUSTER; GENETIC POLYMORPHISM; GENETIC REGULATION; GENETIC RISK; GENOTYPE; GRAFT REJECTION; HEART GRAFT; HUMAN; INTRON; MALE; MONONUCLEAR CELL; MULTIVARIATE ANALYSIS; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS;

ADULT; ALLELES; CELLS, CULTURED; FEMALE; GENOTYPE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; PROTEIN ISOFORMS; SIALOGLYCOPROTEINS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0036773030     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(2002010)32:10<2988::AID-IMMU2988>3.0.CO;2-9     Document Type: Article

References (41)

1. Bianchi, M., Dib, B. and Panerai, A. E., Interleukin-1 and nociception in the rat. J. Neurosci. Res. 1998. 53: 645-650.
2. Inoui, A., Cytokines and sickness behavior: implications from knockout animal models. Trends Immunol. 2001. 22: 469-473.
3. Dinarello, C. A., Ikejima, T, Warner, S. J. C., Orencole, S. F, Lonnemann, G., Cannon, J. G. and Libby, P., Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro. J. Immunol. 1987. 139: 1902-1910.
4. Warner, S. J. C., Auger, K. R. and Libby, P., Interleukin 1 induces interleukin 1. II. Recombinant human interleukin 1 induces interleukin 1 production by adult human vascular endothelial cells. J. Immunol. 1987. 139: 1911-1917.
5. Dinarello, C. A., The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1. N. Engl. J. Med. 2000. 343: 732-734.
6. Mantovani, A., Locati, M., Vecchi, A., Sozzani, S. and Allavena, P., Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines. Trends immunol. 2001. 22: 328-336.
7. McIntyre, K. W., Stepan, G. J., Kolinsky, K. D., Benjamin, W. R., Plocinski, J. M., Kaffka, K. L., Campen, C. A., Chizzonite, R. A. and Kilian, P. L., Inhibition of interleukin 1 (IL-1) binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody. J. Exp. Med. 1991. 173: 931-939.
8. Dunn, E., Sims, J. E., Nicklin, M. J. H. and O'Neill, L. A. J., Annotating genes with potential roles in the immune system: six new members of the IL-1 family. Trends Immunol. 2001. 22: 533-536.
9. Endres, S., Cannon, J. G., Ghorbani, R., Dempsey, R. A., Sisson, S. D., Lonnemann, G., Van der Meer, J. W., Wolff, S. M. and Dinarello, C. A., In vitro production of IL 1β, IL 1α, TNF and IL-2 in healthy subjects: distribution, effect of cyclooxygenase inhibition and evidence of independent gene regulation. Eur. J. Immunol. 1989. 19: 2327-2333.
10. Danis, V. A., Millington, M., Hyland, V. J. and Grennan, D., Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism. Clin. Exp. Immunol. 1995. 99: 303-310.
11. Pociot, F., Mlvig, J., Wogensen, L., Worsaae, H. and Nerup, J., A Taql polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1beta secretion in vitro. Eur J. Clin. Invest 1992. 22: 396-402.
12. Carter, M. J., Jones, S., di Giovine, F. S., Camp, N. J., Lobo, A. J. and Duff, G. W., Allele 2 of the interleukin-1 receptor antagonist gene polymorphism is associated with reduced expression of interleukin-1 receptor antagonist in ulcerative colitis. Gastroenterology 1998. 114: A947.
13. Hurme, M. and Santtila, S., IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1 Ra and IL-1beta genes. Eur. J. Immunol. 1998. 28: 2598-2602.
14. Santtila, S., Savinainen, K. and Hurme, M., Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1 beta production in vitro. Scand. J. Immunol. 1998. 47: 195-198.
15. Wilkinson, R. J., Patel, P., Llewelyn, M., Hirsch, C. S., Pasvol, G., Snounou, G., Davidson, R. N. and Toossi, Z., Influence of polymorphism in the genes for the interleukin (IL)-1 receptor antagonist and IL-1beta on tuberculosis. J. Exp. Med. 1999. 189: 1863-1873.
16. Dewberry, R., Holden, H., Crossman, D. and Francis, S., Interleukin-1 receptor antagonist expression in human endothelial cells and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2000. 20: 2394-2400.
17. Blakemore, A. I., Tarlow, J. K., Cork, M. J., Gordon, C., Emery, P. and Duff, G. W., Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus. Arthritis Rheum. 1994. 37: 1380-1385.
18. Blakemore, A. I., Watson, P. F., Weetman, A. P. and Duff, G. W., Association of Graves' disease with an allele of the interleukin-1 receptor antagonist gene. J. Clin. Endocrinol. Metabol. 1995. 80: 111-115.
19. Keen, R. W., Woodford-Richens, K. L., Lanchbury, J. S. and Spector, T. D., Allelic variation at the interleukin-1 receptor antagonist gene is associated with early postmenopausal bone loss at the spine. Bone 1998. 23: 367-371.
20. Perrier, S., Coussediere, C., Dubost, J. J., Albuisson, E. and Sauvezie, B., IL-1 receptor antagonist (IL-1RA) gene polymorphism in Sjogren's syndrome and rheumatoid arthritis. Clin. Immunol. Immunopathol. 1998. 87: 309-313.
21. Francis, S. E., Camp, N. J., Dewberry, R. M., Gunn, X, Syrris, P., Carter, N. D., Jeffery, S., Kaski, J. C., Cumberland, D. C., Duff, G. W. and Crossman, D. C., Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease. Circulation 1999. 99: 861-866.
22. El-Omar, E. M., Carrington, M., Chow, W. H., McColl, K. E., Bream, J. H., Young, H. A., Herrera, J., Lissowska, J., Yuan, C. C., Rothman, N., Lanyon, G., Martin, M., Fraumeni, J. F. Jr. and Rabkin, C. S., Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000. 404: 398-402.
23. Carter, M. J., di Giovine, F. S., Jones, S., Mee, J., Camp, N. J., Lobo, A. J. and Duff, G. W., Association of the interleukin 1 receptor antagonist gene with ulcerative colitis in Northern European Caucasians. Gut 2001. 48: 461-467.
24. Vamvakopoulos, J. E., Taylor, C. J., Green, C., McNeil, K. and Metcalfe, S., Genetic modulators of interleukin 1 activity influence the development of chronic rejection in human thoracic allografts. Transplant. Proc. 2001. 33: 1563-1564.
25. Vamvakopoulos, J. E., Taylor, C. J., Green, C., McNeil, K., Wallwork, J., Goodman, R. and Metcalfe, S., Interleukin 1 and chronic rejection: possible genetic links in human thoracic allografts. Am. J. Transplant. 2002. 2: 76-83.
26. Fenton, M. J., Vermeulen, M. W., Clark, B. D., Webb, A. C. and Auron, P. E., Human pro-IL-1 beta gene expression in monocytic cells is regulated by two distinct pathways. J. Immunol. 1988. 140: 2267-2273.
27. Arbour, N. C., Lorenz, E., Schutte, B. C., Zabner, J., Kline, J. N., Jones, M., Frees, K., Watt, J. L. and Schwartz, D. A., TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 2000. 25: 187-191.
28. Hubacek, J. A., Pitha, J., Skodova, Z., Stanek, V. and Poledne, R., C(-260)T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction. Circulation 1999. 99: 3218-3220.
29. Malhotra, R. and Bird, M. I., L-selectin: a novel receptor for lipopolysaccharide and its potential role in bacterial sepsis. Bioessays 1997. 19: 919-923.
30. Medvedev, A. E., Flo, T., Ingalls, R. R., Golenbock, D. T., Teti, G., Vogel, S. N. and Espevik, T., Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls. J. Immunol. 1998. 160: 4535-4542.
31. Butcher, C., Steinkasserer, A., Tejura, S. and Lennard, A. C., Comparison of two promoters controlling expression of secreted or intracellular interleukin-1 receptor antagonist. J. Immunol. 1994. 153: 701-711.
32. Uhl, J., Newton, R. C., Giri, J. G., Sandlin, G. and Horuk, R., Identification of IL-1 receptors on human monocytes. J. Immunol. 1989. 142: 1576-1581.
33. Spriggs, M. K., Nevens, P. J., Grabstein, K., Dower, S. K., Cosman, D., Armitage, R. J., McMahan, C. J. and Sims, J. E., Molecular characterization of the interleukin-1 receptor (IL1R) on monocytes and polymorphonuclear cells. Cytokine 1992. 4: 90-95.
34. Clay, F. E., Tarlow, J. K., Cork, M. J., Cox, A., Nicklin, M. J. H. and Duff, G. W., Novel interleukin-1 receptor antagonist exon polymorphisms and their use in allele-specific mRNA assessment. Hum. Genet. 1996. 97: 723-726.
35. Boraschi, D., Rambaldi, A., Sica, A., Ghiara, P., Colotta, F., Wang, J. M., de Rossi, M., Zoia, C., Remuzzi, G. and Bussolino, F., Endothelial cells express the interleukin-1 receptor type 1. Blood 1991. 78: 1262-1767.
36. Akeson, A. L., Mosher, L. B., Woods, C. W., Schroeder, K. K. and Bowlin, I L., Human aortic endothelial cells express the type I but not the type II receptor for interleukin-1 (IL-1). J. Cell. Physiol. 1992. 153: 583-588.
37. Nicklin, M. J. H., Hughes, D. E., Barton, J. L., Ure, J. M. and Duff, G. W., Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene. J. Exp. Med. 2000. 191: 303-311.
38. Rubartelli, A., Cozzolino, F., Talio, M. and Sitia, R., A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence. EMBO J. 1990. 9: 1503-1510.
39. Arend, W. P., Malyak, M., Guthridge, C. J. and Gabay, C., Interleukin-1 receptor antagonist: role in biology. Annu. Rev. Immunol. 1998. 16: 27-55.
40. Sander, B., Andersson, J. and Andersson, U., Assessment of cytokines by immunofluorescence and the paraformaldehydesaponin procedure. Immunol. Rev. 1991. 119: 65-93.
41. Tarlow, J. K., Blakemore, A. I. F., Lennard, A., Solari, R., Hughes, H. N., Steinkasserer, A. and Duff, G. W., Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum. Genet. 1993. 91: 403-404.