The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells

Journal of Experimental Medicine

Volumn 194, Issue 12, 2001, Pages 1813-1821

  Lechmann, Matthias ^a   Krooshoop, Daniëlle J E B ^b   Dudziak, Diana ^c   Kremmer, Elisabeth ^c   Kuhnt, Christine ^a   Figdor, Carl G ^b   Schuler, Gerold ^a   Steinkasserer, Alexander ^a,d  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d Dept of Dermatology ^*  (Germany)

Author keywords

CD83; Dendritic cells; MLR; Recombinant expression; T cell inhibition

Indexed keywords

CD83 ANTIGEN; IMMUNOGLOBULIN;

ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THROMBOCYTE ADHESION;

ANTIGEN PRESENTATION; ANTIGENS, CD; CELL COMMUNICATION; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; ESCHERICHIA COLI; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULINS; LIGANDS; MEMBRANE GLYCOPROTEINS; PROTEIN BINDING; T-LYMPHOCYTES;

EID: 0035905461     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.12.1813     Document Type: Article

References (29)

1. The dendritic cell system and its role in immunogenicity
2. Dendritic cells and the control of immunity
3. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites
4. A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily
5. Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes
6. The mouse Cd83 gene: Structure, domain organization, and chromosome localization
7. Cloning, recombinant expression and biochemical characterization of the murine CD83 molecule which is specifically upregulated during dendritic cell maturation
8. Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1
9. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily
10. + dendritic cells
11. Inhibition of CD83 cell surface expression during dendritic cell maturation by interference with nuclear export of CD83mRNA
12. Mature dendritic cells infected with Herpes Simplex virus type 1 exhibit inhibited T-cell stimulatory capacity
13. High frequency of adhesion defects in B-lineage acute lymphoblastic leukemia
14. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood
15. Human dendritic cells transfected with either RNA or DNA encoding influenza matrix protein M1 differ in their ability to stimulate cytotoxic T lymphocytes
16. The minimum peptide epitope from the influenza virus matrix protein. Extra and intracellular loading of HLA-A2
17. + T lymphocytes producing tumor necrosis factor α spots in response to peptide antigens
18. Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy
19. Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies
20. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
21. CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: Inhibition of cell-mediated and humoral immune responses in vivo
22. + T cells
23. Blockade of the CD28 co-stimulatory pathway: A means to induce tolerance
24. Soluble CD86 is a costimulatory molecule for human T lymphocytes
25. A soluble form of CD83 is released from activated dendritic cells and B lymphocytes, and is detectable in normal human sera
26. Poxvirus as a vector to transduce human dendritic cells for immunotherapy: Abortive infection but reduced APC function
27. Inhibition of dendritic cell maturation by herpes simplex virus
28. Vaccinia virus-related events and phenotypic changes after infection of dendritic cells derived from human monocytes
29. Vaccinia virus inhibits the maturation of human dendritic cells: A novel mechanism of immune evasion