Role of cAMP in the promotion of colorectal cancer cell growth by Prostaglandin E2

BMC Cancer

Volumn 8, Issue , 2008, Pages

  Löffler, Ivonne ^a   Grün, Michael ^a   Böhmer, Frank D ^a   Rubio, Ignacio ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

11 DEOXYPROSTAGLANDIN E1; BUTAPROST; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; LYSOPHOSPHATIDIC ACID; PERTUSSIS TOXIN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN E3 RECEPTOR; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; SULPROSTONE; UNCLASSIFIED DRUG; DNA; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PTGER3 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CANCER GROWTH; CELL PROLIFERATION; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; GROWTH REGULATION; HUMAN; HUMAN CELL; MITOGENICITY; NUCLEOTIDE SEQUENCE; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CELL GROWTH; CELL STRAIN CACO 2; CELL STRAIN HT29; COLORECTAL TUMOR; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; METABOLISM; PATHOLOGY;

APOPTOSIS; CACO-2 CELLS; CELL GROWTH PROCESSES; COLORECTAL NEOPLASMS; CYCLIC AMP; DINOPROSTONE; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HT29 CELLS; HUMANS; RECEPTORS, PROSTAGLANDIN E;

EID: 58149389179     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-8-380     Document Type: Article

References (60)

1. Gupta RA Dubois RN Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 Nat Rev Cancer 2001, 1:11-21 10.1038/ 35094017 11900248
2. Liu CH Chang SH Narko K Trifan OC Wu MT Smith E Haudenschild C Lane TF Hla T Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice J Biol Chem 2001, 276:18563-18569 10.1074/jbc.M010787200 11278747
3. Neufang G Furstenberger G Heidt M Marks F Muller-Decker K Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin Proc Natl Acad Sci USA 2001, 98:7629-7634 34719 11381142 10.1073/pnas.121574098
4. Eberhart CE Coffey RJ Radhika A Giardiello FM Ferrenbach S DuBois RN Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas Gastroenterology 1994, 107:1183-1188 7926468
5. Oshima M Dinchuk JE Kargman SL Oshima H Hancock B Kwong E Trzaskos JM Evans JF Taketo MM Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2) Cell 1996, 87:803-809 10.1016/S0092-8674(00)81988-1 8945508
6. Yang VW Shields JM Hamilton SR Spannhake EW Hubbard WC Hylind LM Robinson CR Giardiello FM Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis Cancer Res 1998, 58:1750-1753 9563494
7. Rigas B Goldman IS Levine L Altered eicosanoid levels in human colon cancer J Lab Clin Med 1993, 122:518-523 8228569
8. Pugh S Thomas GA Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2 Gut 1994, 35:675-678 1374755 8200564 10.1136/gut.35.5.675
9. Reddy BS Rao CV Rivenson A Kelloff G Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats Carcinogenesis 1993, 14:1493-1497 10.1093/carcin/14.8.1493 8353834
10. Hansen-Petrik MB McEntee MF Jull B Shi H Zemel MB Whelan J Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice Cancer Res 2002, 62:403-408 11809688
11. Kawamori T Uchiya N Sugimura T Wakabayashi K Enhancement of colon carcinogenesis by prostaglandin E2 administration Carcinogenesis 2003, 24:985-990 10.1093/carcin/bgg033 12771044
12. Wang D Wang H Shi Q Katkuri S Walhi W Desvergne B Das SK Dey SK DuBois RN Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta Cancer Cell 2004, 6:285-295 10.1016/j.ccr.2004.08.011 15380519
13. Hull MA Ko SC Hawcroft G Prostaglandin EP receptors: Targets for treatment and prevention of colorectal cancer? Mol Cancer Ther 2004, 3:1031-1039 15299086
14. Sugimoto Y Narumiya S Prostaglandin E receptors J Biol Chem 2007, 282:11613-11617 10.1074/jbc.R600038200 17329241
15. Kotani M Tanaka I Ogawa Y Usui T Tamura N Mori K Narumiya S Yoshimi T Nakao K Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3) Genomics 1997, 40:425-434 10.1006/geno.1996.4585 9073510
16. Bilson HA Mitchell DL Ashby B Human prostaglandin EP3 receptor isoforms show different agonist-induced internalization patterns FEBS Lett 2004, 572:271-275 10.1016/j.febslet.2004.06.089 15304361
17. Qiao L Kozoni V Tsioulias GJ Koutsos MI Hanif R Shiff SJ Rigas B Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo Biochim Biophys Acta 1995, 1258:215-223 7548186
18. Pai R Soreghan B Szabo IL Pavelka M Baatar D Tarnawski AS Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy Nat Med 2002, 8:289-293 10.1038/nm0302-289 11875501
19. Chell SD Witherden IR Dobson RR Moorghen M Herman AA Qualtrough D Williams AC Paraskeva C Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence Cancer Res 2006, 66:3106-3113 10.1158/0008-5472.CAN-05-3702 16540660
20. Cassano G Gasparre G Susca F Lippe C Guanti G Effect of prostaglandin E(2) on the proliferation, Ca(2+) mobilization and cAMP in HT-29 human colon adenocarcinoma cells Cancer Lett 2000, 152:217-222 10.1016/ S0304-3835(00)00339-6 10773415
21. Parker J Kaplon MK Alvarez CJ Krishnaswamy G Prostaglandin H synthase expression is variable in human colorectal adenocarcinoma cell lines Exp Cell Res 1997, 236:321-329 10.1006/excr.1997.3741 9344613
22. Sheng H Shao J Morrow JD Beauchamp RD DuBois RN Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells Cancer Res 1998, 58:362-366 9443418
23. Nishihara H Kizaka-Kondoh S Insel PA Eckmann L Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2 Proc Natl Acad Sci USA 2003, 100:8921-8926 166414 12837940 10.1073/pnas.1533221100
24. Hanif R Pittas A Feng Y Koutsos MI Qiao L Staiano-Coico L Shiff SI Rigas B Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway Biochem Pharmacol 1996, 52:237-245 10.1016/0006-2952(96)00181-5 8694848
25. Kvirkvelia N Vojnovic I Warner TD Athie-Morales V Free P Rayment N Chain BM Rademacher TW Lund T Roitt IM Delves PJ Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells Clin Exp Immunol 2002, 127:263-269 1906325 11876748 10.1046/j.1365-2249.2002.01718.x
26. Shoji Y Takahashi M Kitamura T Watanabe K Kawamori T Maruyama T Sugimoto Y Negishi M Narumiya S Sugimura T Wakabayashi K Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development Gut 2004, 53:1151-1158 1774140 15247185 10.1136/gut.2003.028787
27. Han C Michalopoulos GK Wu T Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells J Cell Physiol 2006, 207:261-270 10.1002/ jcp.20560 16331686
28. Lengauer C Kinzler KW Vogelstein B Genetic instability in colorectal cancers Nature 1997, 386:623-627 10.1038/386623a0 9121588
29. Hsi LC Baek SJ Eling TE Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells Exp Cell Res 2000, 256:563-570 10.1006/ excr.2000.4863 10772828
30. Tsuji S Kawano S Sawaoka H Takei Y Kobayashi I Nagano K Fusamoto H Kamada T Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines Prostaglandins Leukot Essent Fatty Acids 1996, 55:179-183 10.1016/S0952-3278(96)90095-2 8931116
31. Qiao L Koutsos M Tsai LL Kozoni V Guzman J Shiff SJ Rigas B Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells Cancer Lett 1996, 107:83-89 10.1016/0304-3835(96)04346-7 8913270
32. Takafuji V Cosme R Lublin D Lynch K Roche JK Prostanoid receptors in intestinal epithelium: Selective expression, function, and change with inflammation Prostaglandins Leukot Essent Fatty Acids 2000, 63:223-235 10.1054/plef.2000.0144 11049698
33. Shao J Jung C Liu C Sheng H Prostaglandin E2 Stimulates the beta-catenin/ T cell factor-dependent transcription in colon cancer J Biol Chem 2005, 280:26565-26572 10.1074/jbc.M413056200 15899904
34. Terrin A Di Benedetto G Pertegato V Cheung YF Baillie G Lynch MJ Elvassore N Prinz A Herberg FW Houslay MD Zaccolo M PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: Role of compartmentalized phosphodiesterases J Cell Biol 2006, 175:441-451 2064521 17088426 10.1083/jcb.200605050
35. Moolenaar WH van Meeteren LA Giepmans BN The ins and outs of lysophosphatidic acid signaling Bioessays 2004, 26:870-881 10.1002/ bies.20081 15273989
36. An S Yang J So SW Zeng L Goetzl EJ Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals Biochemistry 1994, 33:14496-14502 10.1021/bi00252a016 7981210
37. Kotani M Tanaka I Ogawa Y Usui T Mori K Ichikawa A Narumiya S Yoshimi T Nakao K Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: Multiple second messenger systems and tissue-specific distributions Mol Pharmacol 1995, 48:869-879 7476918
38. Jin J Mao GF Ashby B Constitutive activity of human prostaglandin E receptor EP3 isoforms Br J Pharmacol 1997, 121:317-323 1564678 9154343 10.1038/sj.bjp.0701121
39. Schmid A Thierauch KH Schleuning WD Dinter H Splice variants of the human EP3 receptor for prostaglandin E2 Eur J Biochem 1995, 228:23-30 10.1111/j.1432-1033.1995.tb20223.x 7883006
40. Davies H Bignell GR Cox C Stephens P Edkins S Clegg S Teague J Woffendin H Garnett MJ Bottomley W Davis N Dicks E Ewing R Floyd Y Gray K Hall S Hawes R Hughes J Kosmidou V Menzies A Mould C Parker A Stevens C Watt S Hooper S Wilson R Jayatilake H Gusterson BA Cooper C Shipley J Hargrave D Pritchard-Jones K Maitland N Chenevix-Trench G Riggins GJ Bigner DD Palmieri G Cossu A Flanagan A Nicholson A Ho JW Leung SY Yuen ST Weber BL Seigler HF Darrow TL Paterson H Marais R Marshall CJ Wooster R Stratton MR Futreal PA Mutations of the BRAF gene in human cancer Nature 2002, 417:949-954 10.1038/nature00766 12068308
41. Gayet J Zhou XP Duval A Rolland S Hoang JM Cottu P Hamelin R Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines Oncogene 2001, 20:5025-5032 10.1038/sj.onc.1204611 11526487
42. Rowan AJ Lamlum H Ilyas M Wheeler J Straub J Papadopoulou A Bicknell D Bodmer WF Tomlinson IP APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits" Proc Natl Acad Sci USA 2000, 97:3352-3357 16243 10737795 10.1073/pnas.97.7.3352
43. Chien CC Chang CC Yang SH Chen SH Huang CJ A homologue of the Drosophila headcase protein is a novel tumor marker for early-stage colorectal cancer Oncol Rep 2006, 15:919-926 16525680
44. Mengeaud V Nano JL Fournel S Rampal P Effects of eicosapentaenoic acid, gamma-linolenic acid and prostaglandin E1 on three human colon carcinoma cell lines Prostaglandins Leukot Essent Fatty Acids 1992, 47:313-319 10.1016/0952-3278(92)90204-V 1337209
45. Wilson JW Potten CS The effect of exogenous prostaglandin administration on tumor size and yield in Min/+ mice Cancer Res 2000, 60:4645-4653 10969819
46. Reno F Baj G Surico N Cannas M Exogenous prostaglandin E2 inhibits TPA induced matrix metalloproteinase-9 production in MCF-7 cells Prostaglandins Other Lipid Mediat 2004, 73:237-247 10.1016/ j.prostaglandins.2004.03.002 15287155
47. Sheng H Shao J Washington MK DuBois RN Prostaglandin E2 increases growth and motility of colorectal carcinoma cells J Biol Chem 2001, 276:18075-18081 10.1074/jbc.M009689200 11278548
48. Shao J Evers BM Sheng H Prostaglandin E2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells J Biol Chem 2004, 279:14287-14293 10.1074/jbc.M313276200 14742435
49. Regan JW EP2 and EP4 prostanoid receptor signaling Life Sci 2003, 74:143-153 10.1016/j.lfs.2003.09.031 14607241
50. Jabbour HN Boddy SC Prostaglandin E2 induces proliferation of glandular epithelial cells of the human endometrium via extracellular regulated kinase 1/2-mediated pathway J Clin Endocrinol Metab 2003, 88:4481-4487 10.1210/jc.2003-030297 12970327
51. Hashimoto N Watanabe T Ikeda Y Yamada H Taniguchi S Mitsui H Kurokawa K Prostaglandins induce proliferation of rat hepatocytes through a prostaglandin E2 receptor EP3 subtype Am J Physiol 1997, 272:G597-604 9124580
52. Pauli M Anesini C Werner S Borda E Paradoxical role of PGE2 and cAMP in Actinobacillus actinomycetemcomitants strain Y4-induced lymphocyte proliferation Prostaglandins Leukot Essent Fatty Acids 1999, 61:131-136 10.1054/plef.1999.0082 10509869
53. Hawcroft G Ko CW Hull MA Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells Oncogene 2007, 26:3006-3019 10.1038/sj.onc.1210113 17130837
54. van Meeteren LA Moolenaar WH Regulation and biological activities of the autotaxin-LPA axis Prog Lipid Res 2007, 46:145-160 10.1016/ j.plipres.2007.02.001 17459484
55. Lyons J Landis CA Harsh G Vallar L Grunewald K Feichtinger H Duh QY Clark OH Kawasaki E Bourne HR Two G protein oncogenes in human endocrine tumors Science 1990, 249:655-659 10.1126/science.2116665 2116665
56. van Corven EJ Hordijk PL Medema RH Bos JL Moolenaar WH Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts Proc Natl Acad Sci USA 1993, 90:1257-1261 45851 7679495 10.1073/pnas.90.4.1257
57. Wang D Buchanan FG Wang H Dey SK DuBois RN Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade Cancer Res 2005, 65:1822-1829 10.1158/ 0008-5472.CAN-04-3671 15753380
58. Yano T Zissel G Muller-Qernheim J Jae Shin S Satoh H Ichikawa T Prostaglandin E2 reinforces the activation of Ras signal pathway in lung adenocarcinoma cells via EP3 FEBS Lett 2002, 518:154-158 10.1016/ S0014-5793(02)02689-3 11997037
59. Donnini S Finetti F Solito R Terzuoli E Sacchetti A Morbidelli L Patrignani P Ziche M EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways Faseb J 2007. 17384145
60. Buchanan FG Wang D Bargiacchi F DuBois RN Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor J Biol Chem 2003, 278:35451-35457 10.1074/jbc.M302474200 12824187