Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 t cells

Clinical and Experimental Immunology

Volumn 127, Issue 2, 2002, Pages 263-269

  Kvirkvelia, N ^a   Vojnovic, I ^b   Warner, T D ^b   Athie Morales, V ^c   Free, P ^a   Rayment, N ^a   Chain, B M ^a   Rademacher, T W ^a   Lund, T ^a   Roitt, I M ^a   Delves, P J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

CTLL 2; Cyclooxygenase 2; Fetomaternal; Immunosuppression; Th1,Th2

Indexed keywords

CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; DYFLOS; INDOMETACIN; INTERLEUKIN 2; L 161; L 818638; L 826266; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; RECEPTOR SUBUNIT; 3 2( PROPYLOXY) (4 METHYLSULFONYLPHENYL) (5,5 DIMETHYL)FURANONE; 3-2(-PROPYLOXY)-(4-METHYLSULFONYLPHENYL)-(5,5-DIMETHYL)FURANONE; BENZENE DERIVATIVE; EP4 RECEPTOR; FURAN DERIVATIVE; ISOENZYME; MEMBRANE PROTEIN; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS2 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL TYPE; CHORION VILLUS; CONTROLLED STUDY; DRUG INHIBITION; ENZYME SPECIFICITY; EXPLANT; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; ISOLATION PROCEDURE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PLACENTA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; SUPERNATANT; SYNCYTIOTROPHOBLAST; T LYMPHOCYTE; THERMOSTABILITY; ANIMAL; CELL DIVISION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; IMMUNOLOGICAL TOLERANCE; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; PREGNANCY; SECRETION;

ANIMALS; BENZENE DERIVATIVES; CELL DIVISION; CHORIONIC VILLI; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; DINOPROSTONE; FEMALE; FURANS; HUMANS; IMMUNE TOLERANCE; INDOMETHACIN; INTERLEUKIN-2; ISOENZYMES; MEMBRANE PROTEINS; MICE; PREGNANCY; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, PROSTAGLANDIN E; T-LYMPHOCYTES;

EID: 0036006135     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2002.01718.x     Document Type: Article

References (43)

1. Immunoactive products of placenta. VI. Induction of transient murine T cell anergy by a low-molecular-weight compound obtained from supernatants of human placental cultures
2. Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates
3. T cell awareness of paternal alloantigens during pregnancy
4. Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon?
5. Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy
6. Th1-type immunity is incompatible with successful pregnancy
7. Murine T cell determination of pregnancy outcome
8. Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia
9. Uterine leukocytes: Key players in pregnancy
10. Leucocyte populations and cytokine regulation in human uteroplacental tissues
11. Prevention of allogeneic fetal rejection by tryptophan catabolism
12. Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones
13. A progesterone-dependent immunomodulatory protein alters the Th1/Th2 balance
14. Suppression of lymphocyte allore-activity by early gestational human decidua. I. Characterization of suppressor cells and suppressor molecules
15. Suppression of lymphocyte allore-activity by early gestational human decidua. II. Characterization of the suppressor mechanisms
16. Cyclic AMP directly inhibits IL-2 receptor expression in human T cells: Expression of both p55 and p75 subunits is affected
17. 2 and other cyclic AMP-elevating agents modulate IL-2 and IL-2Ra gene expression at multiple levels
18. 2 promotes the induction of anergy during T helper cell recognition of myelin basic protein
19. 2: A novel paradigm for the induction of T-cell anergy
20. 2 differentially modulates cytokine secretion profiles of human T helper lymphocytes
21. 2, promote type 2 cytokine production in maturing human naive T helper cells
22. Final maturation of dendritic cells is associated with impaired responsiveness to IFN-γ and to bacterial IL-12 inducers: Decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells
23. 2 and tumor necrosis factor α cooperate to activate human dendritic cells: Synergistic activation of interleukin 12 production
24. Immunoregulation by macrophages. III. Prostaglandin E suppresses lymphocyte activation but not macrophage effector function during Salmonella enteritidis infection
25. 2 inhibits production of Th1 lymphokines but not of Th2 lymphokines
26. 2 inhibits the nuclear transcription of the human interleukin 2, but not the IL-4, gene in human T cells by targeting transcription factors AP-1 and NF-AT
27. Immunoactive products of human placenta. I. An immunoregulatory factor obtained from explant cultures of human placenta inhibits CTL generation and cytotoxic effector activity
28. In vitro and in vivo immunosuppressive effects of supernatants from human choriocarcinoma cell lines
29. Suppression of local and systemic GVHR by supernatants from human choriocarcinoma cell lines
30. Regulation of T-cell activities at the feto-placental interface - By placenta?
31. 2
32. 2 in lipopolysaccharide-stimulated rat peritoneal macrophages
33. Prostanoid receptors: Structures, properties, and functions
34. 2 or the β-adrenergic receptors: Relationship between PKA activity and inhibition of anti-CD3 monoclonal antibody-induced T cell proliferation
35. 2
36. 2 promotes B lymphocyte Ig isotype switching to IgE
37. The effect of cyclic-AMP on the regulation of c-myc expression in T lymphoma cells
38. 2 and other cyclic adenosine monophosphate-elevating agents: Impact on interleukin-2 receptor signaling pathway
39. 2 inhibits IL-2 and IL-4-dependent proliferation of CTLL-2 and HT2 cells
40. Tolerance to the feto-placental 'graft': Ten ways to support a child for nine months
41. 2 suppressed IL-15-mediated human NK cell function through down-regulation of common γ-chain
42. 2 enhancement of interferon-gamma production by antigen-stimulated type 1 helper T cells
43. 2 receptor