Pro-atherogenic effect of interleukin-4 in endothelial cells: Modulation of oxidative stress, nitric oxide and monocyte chemoattractant protein-1 expression

Atherosclerosis

Volumn 187, Issue 2, 2006, Pages 285-291

  Walch, L ^a   Massade, L ^b   Dufilho, M ^a   Brunet, A ^a   Rendu, F ^a  

^a SORBONNE UNIVERSITÉ   (France)

^b INSERM   (France)

Author keywords

Atherosclerosis; Endothelial cells; Interleukin 4; Monocyte chemoattractant protein 1; NADPH oxidase; Nitric oxide

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALLOPURINOL; APOCYNIN; CYTOCHROME C; ENZYME INHIBITOR; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOLIPASE A2 INHIBITOR; PROTEIN GP91 DS TAT; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; RECOMBINANT INTERLEUKIN 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE INHIBITOR; ROTENONE; SUPEROXIDE DISMUTASE; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; ATHEROGENESIS; CELL LINE; CONTROLLED STUDY; ELECTROCHEMICAL ANALYSIS; ENDOTHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INCUBATION TIME; MOLECULAR PROBE; OXIDATIVE STRESS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ARACHIDONIC ACIDS; ATHEROSCLEROSIS; CHEMOKINE CCL2; CHROMONES; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; INTERLEUKIN-4; MORPHOLINES; NADPH OXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS;

EID: 33745506995     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2005.09.016     Document Type: Article

References (33)

1. von der Thusen J.H., Kuiper J., van Berkel T.J., and Biessen E.A. Interleukins in atherosclerosis: molecular pathways and therapeutic potential. Pharmacol Rev 55 (2003) 133-166
2. Sasaguri T., Arima N., Tanimoto A., Shimajiri S., Hamada T., and Sasaguri Y. A role for interleukin 4 in production of matrix metalloproteinase 1 by human aortic smooth muscle cells. Atherosclerosis 138 (1998) 247-253
3. Uyemura K., Demer L.L., Castle S.C., et al. Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis. J Clin Invest 97 (1996) 2130-2138
4. Frostegard J., Ulfgren A.K., Nyberg P., et al. Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines. Atherosclerosis 145 (1999) 33-43
5. Bogdan C., Vodovotz Y., Paik J., Xie Q.W., and Nathan C. Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages. J Leukoc Biol 55 (1994) 227-233
6. Seder R.A., and Paul W.E. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 12 (1994) 635-673
7. Davenport P., and Tipping P.G. The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice. Am J Pathol 163 (2003) 1117-1125
8. George J., Shoenfeld Y., Gilburd B., Afek A., Shaish A., and Harats D. Requisite role for interleukin-4 in the acceleration of fatty streaks induced by heat shock protein 65 or Mycobacterium tuberculosis. Circ Res 86 (2000) 1203-1210
9. King V.L., Szilvassy S.J., and Daugherty A. Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- mice. Arterioscler Thromb Vasc Biol 22 (2002) 456-461
10. Huber S.A., Sakkinen P., David C., Newell M.K., and Tracy R.P. T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia. Circulation 103 (2001) 2610-2616
11. Lee Y.W., Kuhn H., Hennig B., Neish A.S., and Toborek M. IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells. J Mol Cell Cardiol 33 (2001) 83-94
12. Lee Y.W., Hennig B., and Toborek M. Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cells. Am J Physiol Heart Circ Physiol 284 (2003) H185-H192
13. Griendling K.K. Novel NAD(P)H oxidases in the cardiovascular system. Heart 90 (2004) 491-493
14. Munzel T., Afanas'ev I.B., Kleschyov A.L., and Harrison D.G. Detection of superoxide in vascular tissue. Arterioscler Thromb Vasc Biol 22 (2002) 1761-1768
15. Rey F.E., Cifuentes M.E., Kiarash A., Quinn M.T., and Pagano P.J. Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O(2)(-) and systolic blood pressure in mice. Circ Res 89 (2001) 408-414
16. Benov L., Sztejnberg L., and Fridovich I. Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical. Free Radic Biol Med 25 (1998) 826-831
17. Lantoine F., Iouzalen L., Devynck M.A., Millanvoye-Van Brussel E., and David-Dufilho M. Nitric oxide production in human endothelial cells stimulated by histamine requires Ca2+ influx. Biochem J 330 Pt 2 (1998) 695-699
18. Gorlach A., Brandes R.P., Nguyen K., Amidi M., Dehghani F., and Busse R. A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. Circ Res 87 (2000) 26-32
19. Griendling K.K., Sorescu D., and Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 86 (2000) 494-501
20. Li J.M., Mullen A.M., Yun S., Wientjes F., Brouns G.Y., Thrasher A.J., et al. Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha. Circ Res 90 (2002) 143-150
21. Frey R.S., Rahman A., Kefer J.C., Minshall R.D., and Malik A.B. PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells. Circ Res 90 (2002) 1012-1019
22. Young J.L., Libby P., and Schonbeck U. Cytokines in the pathogenesis of atherosclerosis. Thromb Haemost 88 (2002) 554-567
23. Li J.M., and Shah A.M. Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells. J Biol Chem 277 (2002) 19952-19960
24. Bae Y.S., Sung J.Y., Kim O.S., et al. Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase. J Biol Chem 275 (2000) 10527-10531
25. Yamamori T., Inanami O., Nagahata H., and Kuwabara M. Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt. Biochem Biophys Res Commun 316 (2004) 720-730
26. Zhan Y., Virbasius J.V., Song X., Pomerleau D.P., and Zhou G.W. The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides. J Biol Chem 277 (2002) 4512-4518
27. Zhao X., Bey E.A., Wientjes F.B., and Cathcart M.K. Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox). J Biol Chem 277 (2002) 25385-25392
28. Kelly-Welch A.E., Hanson E.M., Boothby M.R., and Keegan A.D. Interleukin-4 and interleukin-13 signaling connections maps. Science 300 (2003) 1527-1528
29. Nelms K., Keegan A.D., Zamorano J., Ryan J.J., and Paul W.E. The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol 17 (1999) 701-738
30. Patel R.P., Moellering D., Murphy-Ullrich J., Jo H., Beckman J.S., and Darley-Usmar V.M. Cell signaling by reactive nitrogen and oxygen species in atherosclerosis. Free Radic Biol Med 28 (2000) 1780-1794
31. Khew-Goodall Y., Wadham C., Stein B.N., Gamble J.R., and Vadas M.A. Stat6 activation is essential for interleukin-4 induction of P-selectin transcription in human umbilical vein endothelial cells. Arterioscler Thromb Vasc Biol 19 (1999) 1421-1429
32. Feng J., Han J., Pearce S.F., et al. Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma. J Lipid Res 41 (2000) 688-696
33. Folcik V.A., Aamir R., and Cathcart M.K. Cytokine modulation of LDL oxidation by activated human monocytes. Arterioscler Thromb Vasc Biol 17 (1997) 1954-1961