Erk1/2 phosphorylation and reactive oxygen species formation via nitric oxide and Akt-1/Raf-1 crosstalk in cultured rat cerebellar granule cells exposed to the organic solvent 1,2,4-trimethylcyclohexane

Toxicological Sciences

Volumn 80, Issue 2, 2004, Pages 296-303

  Myhre, Oddvar ^a,b,c   Sterri, Sigrun Hanne ^a   Bogen, Inger Lise ^a   Fonnum, Frode ^a  

^a NORWEGIAN DEFENCE RESEARCH ESTABLISHMENT FFI   (Norway)

^b STATOIL   (Norway)

^c Amersham Health AS   (Norway)

Author keywords

Akt 1; Mitogen activated protein kinases; Nitric oxide; Organic solvents; Raf 1; Reactive oxygen species

Indexed keywords

1,2,4 TRIMETHYLCYCLOHEXANE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALPHA TOCOPHEROL; CELL PROTEIN; DIPHENYLIODONIUM SALT; HYDROCARBON; MITOGEN ACTIVATED PROTEIN KINASE 1; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; ORGANIC SOLVENT; PROTEIN AKT1; PROTEIN RAF1; REACTIVE OXYGEN METABOLITE; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DEPHOSPHORYLATION; EXPOSURE; GRANULE CELL; NEUROTOXICITY; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; BUTADIENES; CELLS, CULTURED; CEREBELLUM; CYCLOHEXANES; CYTOPLASMIC GRANULES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITRILES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS A-RAF; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RECEPTOR CROSS-TALK; SOLVENTS;

EID: 4344559517     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh166     Document Type: Article

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