Heat shock protein 27, a novel regulator of 5-fluorouracil resistance in colon cancer

Oncology Reports

Volumn 20, Issue 5, 2008, Pages 1165-1172

  Tsuruta, Masashi ^a   Nishibori, Hideki ^a,b   Hasegawa, Hirotoshi ^a   Ishii, Yoshiyuki ^a   Endo, Takashi ^a   Kubota, Tetsuro ^a   Kitajima, Masaki ^c   Kitagawa, Yuko ^a  

^a KEIO UNIVERSITY   (Japan)

^b Kitami Gastrointestinal Clinic   (Japan)

^c International University of Health and Welfare Mita Hospital   (Japan)

Author keywords

5 fluorouracil; Colon cancer; Heat shock protein 27; RNA interference

Indexed keywords

FLUOROURACIL; HEAT SHOCK PROTEIN 27; REGULATOR PROTEIN; SMALL INTERFERING RNA; ANTINEOPLASTIC ANTIMETABOLITE;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL STRAIN HCT116; CELL STRAIN HT29; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENSITOMETRY; DOWN REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; REGULATORY MECHANISM; COLON TUMOR; DRUG RESISTANCE; GENETICS; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

ANTIMETABOLITES, ANTINEOPLASTIC; BLOTTING, WESTERN; CELL LINE, TUMOR; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; HSP27 HEAT-SHOCK PROTEINS; HUMANS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 58149327400     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000125     Document Type: Article

References (36)

1. Heidelberger C, Chaudhuri NK, Danneberg P, et al: Fluorinated pyrimidines, a new class of tumor-inhibitory compounds. Nature 179: 663-666, 1957.
2. Meyerhardt JA and Mayer RJ: Systemic therapy for colorectal cancer. N Engl J Med 352: 476-487, 2005.
3. Mader RM, Muller M and Steger GG: Resistance to 5-fluorouracil. Gen Pharmacol 31: 661-666, 1998.
4. Johnston PG, Drake JC, Trepel J and Allegra CJ: Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines. Cancer Res 52: 4306-4312, 1992.
5. Aschele C, Debernardis D, Casazza S, et al: Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy. J Clin Oncol 17: 1760-1770, 1999.
6. Copur S, Aiba K, Drake JC, Allegra CJ and Chu E: Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil. Biochem Pharmacol 49: 1419-1426, 1995.
7. Chu E, Lai GM, Zinn S and Allegra CJ: Resistance of a human ovarian cancer line to 5-fluorouracil associated with decreased levels of 5-fluorouracil in DNA. Mol Pharmacol 38: 410-417, 1990.
8. Zhou ZW, Wang GQ, Wan DS, et al: Relationship between dihydropyrimidine dehydrogenase (DPD) activity and toxicity of 5-FU-based adjuvant chemotherapy in colorectal cancer patients. Ai Zheng 23: 1512-1516, 2004.
9. Takechi T, Koizumi K, Tsujimoto H and Fukushima M: Screening of differentially expressed genes in 5-fluorouracil-resistant human gastrointestinal tumor cells. Jpn J Cancer Res 92: 696-703, 2001.
10. Lindquist S and Craig EA: The heat-shock proteins. Annu Rev Genet 22: 631-677, 1988.
11. Schlesinger MJ: Heat shock proteins. J Biol Chem 265: 12111-12114, 1990.
12. Ovelgonne JH, Koninkx JF, Pusztai A, et al: Decreased levels of heat shock proteins in gut epithelial cells after exposure to plant lectins. Gut 46: 679-687, 2000.
13. Miyazaki T, Kato H, Faried A, et al: Predictors of response to chemo-radiotherapy and radiotherapy for esophageal squamous cell carcinoma. Anticancer Res 25: 2749-2755, 2005.
14. Ciocca DR and Calderwood SK: Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10: 86-103, 2005.
15. Ciocca DR, Fuqua SA, Lock-Lim S, Toft DO, Welch WJ and Mcguire WL: Response of human breast cancer cells to heat shock and chemotherapeutic drugs. Cancer Res 52: 3648-3654, 1992.
16. Garrido C, Ottavi P, Fromentin A, et al: HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs. Cancer Res 57: 2661-2667, 1997.
17. Garrido C, Bruey JM, Fromentin A, Hammann A, Arrigo AP, Solary E: HSP27 inhibits cytochrome c-dependent activation of procaspase-9. FASEB J 13: 2061-2070, 1999.
18. Garrido C, Mehlen P, Fromentin A, et al: Inconstant association between 27-kDa heat-shock protein (Hsp27) content and doxorubicin resistance in human colon cancer cells. Eur J Biochem 637: 653-659, 1996.
19. Vargas-Roig LM, Gago FE, Tello O, Aznar JC and Ciocca DR: Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy. Int J Cancer 79: 468-475, 1998.
20. Suganuma K, Kubota T, Saikawa Y, et al: Possible chemoresistance-related genes for gastric cancer detected by cDNA microarray. Cancer Sci 94: 355-359, 2003.
21. Yamauchi T, Watanabe M, Hasegawa H, et al: The potential for a selective cyclooxygenase-2 inhibitor in the prevention of liver metastasis in human colorectal cancer. Anticancer Res 23: 245-249, 2003.
22. Yamamoto K, Okamoto A, Isonishi S, Ochiai K and Ohtake Y: Heat shock protein 27 was up-regulated in cisplatin resistant human ovarian tumor cell line and associated with the cisplatin resistance. Cancer Lett 168: 173-181, 2001.
23. Hwang PM, Bunz F, Yu J, et al: Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat Med 7: 1111-1117, 2001.
24. Rigas A, Dervenis C, Giannakou N, Kozoni V, Shiff SJ and Rigas B: Selective induction of colon cancer cell apoptosis by 5-fluorouracil in humans. Cancer Invest 20: 657-665, 2002.
25. Voboril R, Hochwald SN, Li J, et al: Inhibition of NF-kappa B augments sensitivity to 5-fluorouracil/folinic acid in colon cancer. J Surg Res 120: 178-188, 2004.
26. Korsmeyer SJ: Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 80: 879-886, 1992.
27. Miyashita T and Reed JC: Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 81: 151-157, 1993.
28. Violette S, Poulain L, Dussaulx E, et al: Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status. Int J Cancer 98: 498-504, 2002.
29. Sun Y, Tang XM, Half E, Kuo MT and Sinicrope FA: Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Cancer Res 62: 6323-6328, 2002.
30. Kluck RM, Bossy-Wetzel E, Green DR and Newmeyer DD: The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275: 1132-1136, 1997.
31. Li P, Nijhawan D, Budihardjo I, et al: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489, 1997.
32. Green DR and Reed JC: Mitochondria and apoptosis. Science 281: 1309-1312, 1998.
33. Martinou JC, Desagher S and Antonsson B: Cytochrome c release from mitochondria: all or nothing. Nat Cell Biol 2: E41-E43, 2000.
34. Konishi T, Sasaki S, Watanabe T, Kitayama J and Nagawa H: Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XL. Oncogene: 2006.
35. Concannon CG, Orrenius S and Samali A: Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both procaspase-3 and cytochrome c. Gene Expr 9: 195-201, 2001.
36. Filomeni G, Aquilano K, Rotilio G and Ciriolo MR: Antiapoptotic response to induced GSH depletion: involvement of heat shock proteins and NF-kappaB activation. Antioxid Redox Signal 7: 446-455, 2005.