Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 3, 2009, Pages 291-297

  Arvidsson, Björn ^a,b   Allard, Erik ^a   Sjögren, Erik ^a   Lennernäs, Hans ^a   Sjöberg, Per Johan Ragnar ^a   Bergquist, Jonas ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

Author keywords

Liquid chromatography; Mass spectrometry; Metabolites; Online; Pig liver; Solid phase extraction; Ximelagatran

Indexed keywords

ANALYSIS METHODS; ANALYTE; BIO FLUIDS; CAPILLARY COLUMNS; CHROMATOGRAPHIC SEPARATIONS; COLUMN STABILITIES; COMPLEX MATRIXES; CONCENTRATION RANGES; FRAGMENT IONS; LC-MS/MS; LIMIT OF QUANTITATIONS; LIQUID CHROMATOGRAPHIC SEPARATIONS; LIVER EXTRACTS; MULTIPLE REACTIONS MONITORING; ONLINE; PIG LIVER; POSITIVE ION MODES; PRODRUG; QUANTITATIVE ANALYSES; SOLID PHASE EXTRACTION; STRUCTURAL SIMILARITIES; TANDEM MASS SPECTROMETRIC DETECTIONS; TIME SEGMENTS; XIMELAGATRAN;

BIOMOLECULES; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION OF LIQUIDS; LIQUID CHROMATOGRAPHY; LIVER; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; PHASE SEPARATION; POSITIVE IONS; SEMICONDUCTOR SWITCHES; SEPARATION; SOLVENT EXTRACTION; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS; TRANSIENTS;

EXTRACTION;

DRUG METABOLITE; LIVER EXTRACT; MELAGATRAN; MELAGATRAN ETHYL ESTER; MELAGATRAN HYDROXYAMIDINE; UNCLASSIFIED DRUG; XIMELAGATRAN;

ARTICLE; CAPILLARY ELECTROPHORESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG LIVER LEVEL; DRUG MONITORING; DRUG RETENTION; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG STRUCTURE; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANIMALS; ANTICOAGULANTS; AZETIDINES; BENZYLAMINES; CHROMATOGRAPHY, LIQUID; LIVER; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; SWINE; TANDEM MASS SPECTROMETRY;

SUIDAE;

EID: 58149289682     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.12.017     Document Type: Article

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