Determination of ximelagatran, an oral direct thrombin inhibitor, its active metabolite melagatran, and the intermediate metabolites, in biological samples by liquid chromatography-mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 783, Issue 2, 2003, Pages 335-347

  Larsson, Marita ^a   Ahnoff, Martin ^a   Abrahamsson, Anna ^a   Logren, Ulrika ^a   Fakt, Christina ^a   Öhrman, Irene ^a   Persson, Bengt Arne ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Esterases; Melagatran; Thrombin; Ximelagatran

Indexed keywords

ACETONITRILE; AMMONIUM COMPOUNDS; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA APPLICATIONS;

HUMAN PLASMA;

METABOLITES;

ACETONITRILE; AMMONIUM ACETATE; FORMIC ACID; MELAGATRAN; SILICON DIOXIDE; THROMBIN INHIBITOR; XIMELAGATRAN; ANTITHROMBIN; AZETIDINE DERIVATIVE; BENZYLAMINE DERIVATIVE; DRUG DERIVATIVE; GLYCINE;

ARTICLE; DRUG DETERMINATION; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SAMPLING; SOLID PHASE EXTRACTION; ANIMAL; BLOOD; BREAST MILK; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MOUSE; RAT; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; URINE;

ANIMALS; ANTITHROMBINS; AZETIDINES; BENZYLAMINES; CHROMATOGRAPHY, LIQUID; GLYCINE; HUMANS; MICE; MILK, HUMAN; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0037437658     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(02)00768-7     Document Type: Article

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