Development and validation of a chiral capillary electrophoresis method for melagatran and ximelagatran drug substances

Journal of Separation Science

Volumn 25, Issue 15-17, 2002, Pages 1167-1174

  Wikström, Håkan ^a   Owens, Paul K ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Capillary electrophoresis; Chiral; Experimental design; Melagatran; Thrombin inhibitor; Validation; Ximelagatran

Indexed keywords

ELECTROLYTES; ELECTROPHORESIS; LIQUID CHROMATOGRAPHY; PH EFFECTS; PHOSPHATES;

DEPLETION;

DRUG PRODUCTS;

BUFFER; CYCLODEXTRIN; HEPTAKIS(2,6 O DIMETHYL) BETA CYCLODEXTRIN; MELAGATRAN; PRODRUG; THROMBIN INHIBITOR; XIMELAGATRAN;

ACCURACY; ANALYTIC METHOD; ARTICLE; CAPILLARY ELECTROPHORESIS; CHIRAL CHROMATOGRAPHY; CHIRALITY; CORRELATION ANALYSIS; DATA ANALYSIS; DRUG DETERMINATION; DRUG PURITY; DRUG STABILITY; DRUG STRUCTURE; ENANTIOMER; ENANTIOSELECTIVITY; LINEAR SYSTEM; LIQUID CHROMATOGRAPHY; ORAL DRUG ADMINISTRATION; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; VALIDATION PROCESS;

EID: 0036920062     PISSN: 16159306     EISSN: None     Source Type: Journal    
DOI: 10.1002/1615-9314(20021101)25:15/17<1167::AID-JSSC1167>3.0.CO;2-8     Document Type: Article

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